(23 nodes) Translesion synthesis by POLK network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113578639	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (528 aa)
	LOC113577231	RPA_C domain-containing protein. (232 aa)
	LOC113577499	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (549 aa)
	uba52	Ubiquitin-like domain-containing protein. (128 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa3	Uncharacterized protein. (122 aa)
	rfc3	AAA domain-containing protein. (356 aa)
	rfc5	AAA domain-containing protein. (363 aa)
	ENSEEEP00000018543	Methionine sulfoxide reductase B1b. (259 aa)
	Rev3l	DNA_pol_B domain-containing protein. (304 aa)
	rfc1	Replication factor C subunit 1. (1124 aa)
	ENSEEEP00000011546	Uncharacterized protein. (890 aa)
	rfc2	AAA domain-containing protein. (369 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	Polk	Uncharacterized protein. (403 aa)
	polk	Polymerase (DNA directed) kappa. (413 aa)
	rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1187 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
	mad2l2	HORMA domain-containing protein. (215 aa)
	kxd1	KxDL domain-containing protein. (183 aa)
	LOC113584157	Ubiquitin-like domain-containing protein. (77 aa)
	rpa2	RPA_C domain-containing protein. (280 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000011546	ENSEEEP00000018543	ENSEEEP00000011546	ENSEEEP00000018543	Uncharacterized protein.	Methionine sulfoxide reductase B1b.	0.787
ENSEEEP00000011546	LOC113577231	ENSEEEP00000011546	ENSEEEP00000028360	Uncharacterized protein.	RPA_C domain-containing protein.	0.566
ENSEEEP00000011546	Polk	ENSEEEP00000011546	ENSEEEP00000007978	Uncharacterized protein.	Uncharacterized protein.	0.637
ENSEEEP00000011546	Rev3l	ENSEEEP00000011546	ENSEEEP00000018397	Uncharacterized protein.	DNA_pol_B domain-containing protein.	0.790
ENSEEEP00000011546	mad2l2	ENSEEEP00000011546	ENSEEEP00000001265	Uncharacterized protein.	HORMA domain-containing protein.	0.675
ENSEEEP00000011546	pcna	ENSEEEP00000011546	ENSEEEP00000028033	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
ENSEEEP00000011546	polk	ENSEEEP00000011546	ENSEEEP00000007972	Uncharacterized protein.	Polymerase (DNA directed) kappa.	0.637
ENSEEEP00000011546	rev1	ENSEEEP00000011546	ENSEEEP00000007242	Uncharacterized protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.688
ENSEEEP00000011546	rfc1	ENSEEEP00000011546	ENSEEEP00000013629	Uncharacterized protein.	Replication factor C subunit 1.	0.691
ENSEEEP00000011546	rfc2	ENSEEEP00000011546	ENSEEEP00000010158	Uncharacterized protein.	AAA domain-containing protein.	0.982
ENSEEEP00000011546	rfc3	ENSEEEP00000011546	ENSEEEP00000022821	Uncharacterized protein.	AAA domain-containing protein.	0.988
ENSEEEP00000011546	rfc4	ENSEEEP00000011546	ENSEEEP00000002918	Uncharacterized protein.	AAA domain-containing protein.	0.984
ENSEEEP00000011546	rfc5	ENSEEEP00000011546	ENSEEEP00000020285	Uncharacterized protein.	AAA domain-containing protein.	0.984
ENSEEEP00000011546	rpa1	ENSEEEP00000011546	ENSEEEP00000001444	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.787
ENSEEEP00000011546	rpa2	ENSEEEP00000011546	ENSEEEP00000044227	Uncharacterized protein.	RPA_C domain-containing protein.	0.566
ENSEEEP00000011546	rpa3	ENSEEEP00000011546	ENSEEEP00000024425	Uncharacterized protein.	Uncharacterized protein.	0.635
ENSEEEP00000011546	rps27a	ENSEEEP00000011546	ENSEEEP00000009424	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.612
ENSEEEP00000018543	ENSEEEP00000011546	ENSEEEP00000018543	ENSEEEP00000011546	Methionine sulfoxide reductase B1b.	Uncharacterized protein.	0.787
ENSEEEP00000018543	LOC113577231	ENSEEEP00000018543	ENSEEEP00000028360	Methionine sulfoxide reductase B1b.	RPA_C domain-containing protein.	0.807
ENSEEEP00000018543	Polk	ENSEEEP00000018543	ENSEEEP00000007978	Methionine sulfoxide reductase B1b.	Uncharacterized protein.	0.537