17 items (Electrophorus electricus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa)
	LOC113569058	AAA_23 domain-containing protein. (469 aa)
	ENSEEEP00000007003	AAA_23 domain-containing protein. (53 aa)
	polq	Polymerase (DNA directed), theta. (2580 aa)
	lig3	DNA ligase. (1009 aa)
	nbn	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1181 aa)
	LOC113582267	Breast cancer 2, early onset. (2391 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
	parp2	Poly [ADP-ribose] polymerase. (572 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	LOC113590030	Uncharacterized protein. (347 aa)
	rbbp8	SAE2 domain-containing protein. (131 aa)
	rad52	RAD52 homolog, DNA repair protein. (287 aa)
	ENSEEEP00000050839	Metallophos domain-containing protein. (106 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000007003	ENSEEEP00000050839	ENSEEEP00000007003	ENSEEEP00000050839	AAA_23 domain-containing protein.	Metallophos domain-containing protein.	0.954
ENSEEEP00000007003	LOC113582267	ENSEEEP00000007003	ENSEEEP00000018632	AAA_23 domain-containing protein.	Breast cancer 2, early onset.	0.536
ENSEEEP00000007003	LOC113590030	ENSEEEP00000007003	ENSEEEP00000033260	AAA_23 domain-containing protein.	Uncharacterized protein.	0.784
ENSEEEP00000007003	fen1	ENSEEEP00000007003	ENSEEEP00000032875	AAA_23 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.784
ENSEEEP00000007003	lig3	ENSEEEP00000007003	ENSEEEP00000008580	AAA_23 domain-containing protein.	DNA ligase.	0.690
ENSEEEP00000007003	mre11	ENSEEEP00000007003	ENSEEEP00000024860	AAA_23 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.954
ENSEEEP00000007003	nbn	ENSEEEP00000007003	ENSEEEP00000010371	AAA_23 domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.936
ENSEEEP00000007003	parp1	ENSEEEP00000007003	ENSEEEP00000030073	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.487
ENSEEEP00000007003	parp2	ENSEEEP00000007003	ENSEEEP00000027142	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.480
ENSEEEP00000007003	parp3	ENSEEEP00000007003	ENSEEEP00000052156	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.423
ENSEEEP00000007003	polq	ENSEEEP00000007003	ENSEEEP00000008137	AAA_23 domain-containing protein.	Polymerase (DNA directed), theta.	0.539
ENSEEEP00000007003	rad52	ENSEEEP00000007003	ENSEEEP00000046727	AAA_23 domain-containing protein.	RAD52 homolog, DNA repair protein.	0.836
ENSEEEP00000007003	rbbp8	ENSEEEP00000007003	ENSEEEP00000034871	AAA_23 domain-containing protein.	SAE2 domain-containing protein.	0.837
ENSEEEP00000007003	xrcc1	ENSEEEP00000007003	ENSEEEP00000030211	AAA_23 domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.633
ENSEEEP00000050839	ENSEEEP00000007003	ENSEEEP00000050839	ENSEEEP00000007003	Metallophos domain-containing protein.	AAA_23 domain-containing protein.	0.954
ENSEEEP00000050839	LOC113569058	ENSEEEP00000050839	ENSEEEP00000005699	Metallophos domain-containing protein.	AAA_23 domain-containing protein.	0.954
ENSEEEP00000050839	LOC113582267	ENSEEEP00000050839	ENSEEEP00000018632	Metallophos domain-containing protein.	Breast cancer 2, early onset.	0.748
ENSEEEP00000050839	LOC113590030	ENSEEEP00000050839	ENSEEEP00000033260	Metallophos domain-containing protein.	Uncharacterized protein.	0.889
ENSEEEP00000050839	fen1	ENSEEEP00000050839	ENSEEEP00000032875	Metallophos domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.889
ENSEEEP00000050839	lig3	ENSEEEP00000050839	ENSEEEP00000008580	Metallophos domain-containing protein.	DNA ligase.	0.747