STRINGSTRING
parp1 parp1 LOC113569058 LOC113569058 ENSEEEP00000007003 ENSEEEP00000007003 polq polq lig3 lig3 nbn nbn rad50 rad50 LOC113582267 LOC113582267 mre11 mre11 parp2 parp2 xrcc1 xrcc1 fen1 fen1 LOC113590030 LOC113590030 rbbp8 rbbp8 rad52 rad52 ENSEEEP00000050839 ENSEEEP00000050839 parp3 parp3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
polqPolymerase (DNA directed), theta. (2580 aa)
lig3DNA ligase. (1009 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
LOC113582267Breast cancer 2, early onset. (2391 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
parp2Poly [ADP-ribose] polymerase. (572 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC113590030Uncharacterized protein. (347 aa)
rbbp8SAE2 domain-containing protein. (131 aa)
rad52RAD52 homolog, DNA repair protein. (287 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
parp3Poly [ADP-ribose] polymerase. (527 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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