17 items (Electrophorus electricus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113590030	Uncharacterized protein. (347 aa)
	rbbp8	SAE2 domain-containing protein. (131 aa)
	ENSEEEP00000007003	AAA_23 domain-containing protein. (53 aa)
	rad52	RAD52 homolog, DNA repair protein. (287 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)
	ENSEEEP00000050839	Metallophos domain-containing protein. (106 aa)
	LOC113569058	AAA_23 domain-containing protein. (469 aa)
	LOC113582267	Breast cancer 2, early onset. (2391 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1181 aa)
	nbn	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
	parp2	Poly [ADP-ribose] polymerase. (572 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	lig3	DNA ligase. (1009 aa)
	polq	Polymerase (DNA directed), theta. (2580 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000007003	ENSEEEP00000050839	ENSEEEP00000007003	ENSEEEP00000050839	AAA_23 domain-containing protein.	Metallophos domain-containing protein.	0.954
ENSEEEP00000007003	LOC113582267	ENSEEEP00000007003	ENSEEEP00000018632	AAA_23 domain-containing protein.	Breast cancer 2, early onset.	0.536
ENSEEEP00000007003	LOC113590030	ENSEEEP00000007003	ENSEEEP00000033260	AAA_23 domain-containing protein.	Uncharacterized protein.	0.784
ENSEEEP00000007003	fen1	ENSEEEP00000007003	ENSEEEP00000032875	AAA_23 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.784
ENSEEEP00000007003	lig3	ENSEEEP00000007003	ENSEEEP00000008580	AAA_23 domain-containing protein.	DNA ligase.	0.690
ENSEEEP00000007003	mre11	ENSEEEP00000007003	ENSEEEP00000024860	AAA_23 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.954
ENSEEEP00000007003	nbn	ENSEEEP00000007003	ENSEEEP00000010371	AAA_23 domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.936
ENSEEEP00000007003	parp1	ENSEEEP00000007003	ENSEEEP00000030073	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.487
ENSEEEP00000007003	parp2	ENSEEEP00000007003	ENSEEEP00000027142	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.480
ENSEEEP00000007003	parp3	ENSEEEP00000007003	ENSEEEP00000052156	AAA_23 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.423
ENSEEEP00000007003	polq	ENSEEEP00000007003	ENSEEEP00000008137	AAA_23 domain-containing protein.	Polymerase (DNA directed), theta.	0.539
ENSEEEP00000007003	rad52	ENSEEEP00000007003	ENSEEEP00000046727	AAA_23 domain-containing protein.	RAD52 homolog, DNA repair protein.	0.836
ENSEEEP00000007003	rbbp8	ENSEEEP00000007003	ENSEEEP00000034871	AAA_23 domain-containing protein.	SAE2 domain-containing protein.	0.837
ENSEEEP00000007003	xrcc1	ENSEEEP00000007003	ENSEEEP00000030211	AAA_23 domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.633
ENSEEEP00000050839	ENSEEEP00000007003	ENSEEEP00000050839	ENSEEEP00000007003	Metallophos domain-containing protein.	AAA_23 domain-containing protein.	0.954
ENSEEEP00000050839	LOC113569058	ENSEEEP00000050839	ENSEEEP00000005699	Metallophos domain-containing protein.	AAA_23 domain-containing protein.	0.954
ENSEEEP00000050839	LOC113582267	ENSEEEP00000050839	ENSEEEP00000018632	Metallophos domain-containing protein.	Breast cancer 2, early onset.	0.748
ENSEEEP00000050839	LOC113590030	ENSEEEP00000050839	ENSEEEP00000033260	Metallophos domain-containing protein.	Uncharacterized protein.	0.889
ENSEEEP00000050839	fen1	ENSEEEP00000050839	ENSEEEP00000032875	Metallophos domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.889
ENSEEEP00000050839	lig3	ENSEEEP00000050839	ENSEEEP00000008580	Metallophos domain-containing protein.	DNA ligase.	0.747