Your Input: | |
| | LOC113568893 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC113568892 | Histone H2B; Belongs to the histone H2B family. (64 aa) |
| | LOC113591092 | Uncharacterized protein. (242 aa) |
| | ENSEEEP00000004594 | TPR_REGION domain-containing protein. (124 aa) |
| | ENSEEEP00000004593 | TPR_REGION domain-containing protein. (132 aa) |
| | sirt6 | Deacetylase sirtuin-type domain-containing protein. (396 aa) |
| | LOC113568250 | RAD51 paralog C. (260 aa) |
| | ENSEEEP00000004035 | Dpoe2NT domain-containing protein. (82 aa) |
| | rmi1 | DUF1767 domain-containing protein. (587 aa) |
| | rfc4 | AAA domain-containing protein. (357 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (616 aa) |
| | pold1 | DNA polymerase. (1061 aa) |
| | LOC113573440 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC113567680 | Small ubiquitin-related modifier. (109 aa) |
| | paxip1 | PAX interacting (with transcription-activation domain) protein 1. (1107 aa) |
| | LOC113583786 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa) |
| | ENSEEEP00000001112 | IBB domain-containing protein. (80 aa) |
| | rmi2 | Uncharacterized protein. (147 aa) |
| | ENSEEEP00000000760 | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | LOC113569455 | Histone H2B; Belongs to the histone H2B family. (67 aa) |
| | ENSEEEP00000000649 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSEEEP00000000319 | Histone domain-containing protein; Belongs to the histone H2B family. (104 aa) |
| | LOC113571395 | Polymerase (DNA directed), epsilon 2. (527 aa) |
| | LOC113567650 | Uncharacterized protein. (1631 aa) |
| | ENSEEEP00000000086 | Uncharacterized protein. (247 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (287 aa) |
| | ENSEEEP00000047072 | Uncharacterized protein. (332 aa) |
| | LOC113576847 | RING-type domain-containing protein. (995 aa) |
| | chek2 | Uncharacterized protein. (526 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (419 aa) |
| | baz1b | Bromodomain adjacent to zinc finger domain, 1B. (1577 aa) |
| | LOC113591480 | Lysine (K)-specific demethylase 4A, genome duplicate b. (917 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | lig4 | DNA ligase. (909 aa) |
| | LOC113576955 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | xrcc6 | Uncharacterized protein. (627 aa) |
| | LOC113578458 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (173 aa) |
| | ENSEEEP00000023290 | RAD9 checkpoint clamp component B. (181 aa) |
| | rfc3 | AAA domain-containing protein. (356 aa) |
| | LOC113579037 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa) |
| | slf1 | ANK_REP_REGION domain-containing protein. (905 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (539 aa) |
| | babam1 | Uncharacterized protein. (359 aa) |
| | pole4 | CBFD_NFYB_HMF domain-containing protein. (127 aa) |
| | abraxas1 | MPN domain-containing protein. (419 aa) |
| | pole3 | CBFD_NFYB_HMF domain-containing protein. (149 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa) |
| | ENSEEEP00000032310 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa) |
| | ccna2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa) |
| | LOC113572424 | Ubiquitin-conjugating enzyme E2 variant 1. (176 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | LOC113590030 | Uncharacterized protein. (347 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2627 aa) |
| | rad51ap1 | RAD51_interact domain-containing protein. (230 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa) |
| | ENSEEEP00000034862 | Protein inhibitor of activated STAT, 4b. (419 aa) |
| | rbbp8 | SAE2 domain-containing protein. (131 aa) |
| | blm | BLM RecQ like helicase. (1281 aa) |
| | eya4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (603 aa) |
| | ENSEEEP00000035351 | Endo/exonuclease/phosphatase domain-containing protein. (429 aa) |
| | rad17 | Uncharacterized protein. (683 aa) |
| | ENSEEEP00000036356 | Histone H2A; Belongs to the histone H2A family. (158 aa) |
| | LOC113567584 | Uncharacterized protein. (377 aa) |
| | LOC113574589 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa) |
| | LOC113577337 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa) |
| | LOC113574046 | Transmembrane protein 182b. (252 aa) |
| | ENSEEEP00000039231 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | LOC113569449 | Histone H4. (103 aa) |
| | XRCC2 | RECA_2 domain-containing protein. (302 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | pold2 | Uncharacterized protein. (469 aa) |
| | ankrd11 | ANK_REP_REGION domain-containing protein. (2837 aa) |
| | LOC113575217 | Importin subunit alpha; Belongs to the importin alpha family. (526 aa) |
| | LOC113578639 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (528 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (615 aa) |
| | LOC113577352 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (366 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (305 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (269 aa) |
| | ENSEEEP00000043756 | XPGI domain-containing protein. (341 aa) |
| | sumo2 | Small ubiquitin-related modifier. (111 aa) |
| | ENSEEEP00000029755 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | sumo1 | Small ubiquitin-related modifier. (121 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa) |
| | spidr | DUF4503 domain-containing protein. (573 aa) |
| | rfc5 | AAA domain-containing protein. (363 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (503 aa) |
| | LOC113589524 | RECA_2 domain-containing protein. (121 aa) |
| | ENSEEEP00000028715 | Uncharacterized protein. (420 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | LOC113577231 | RPA_C domain-containing protein. (232 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (572 aa) |
| | LOC113581660 | Importin subunit alpha; Belongs to the importin alpha family. (508 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4099 aa) |
| | rad1 | Uncharacterized protein. (279 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (527 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (550 aa) |
| | rhno1 | Uncharacterized protein. (308 aa) |
| | ENSEEEP00000051054 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (307 aa) |
| | ENSEEEP00000050839 | Metallophos domain-containing protein. (106 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa) |
| | Rnf169 | RING-type domain-containing protein. (106 aa) |
| | LOC113583736 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (246 aa) |
| | ENSEEEP00000049401 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | LOC113572244 | Endo/exonuclease/phosphatase domain-containing protein. (409 aa) |
| | LOC113577499 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (549 aa) |
| | uba52 | Ubiquitin-like domain-containing protein. (128 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (953 aa) |
| | xrcc5 | Ku domain-containing protein. (740 aa) |
| | rpa2 | RPA_C domain-containing protein. (280 aa) |
| | LOC113584157 | Ubiquitin-like domain-containing protein. (77 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (113 aa) |
| | xrcc4 | Uncharacterized protein. (343 aa) |
| | polm | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (503 aa) |
| | Nsd2 | Uncharacterized protein. (603 aa) |
| | ENSEEEP00000045899 | PWWP domain-containing protein. (460 aa) |
| | kxd1 | KxDL domain-containing protein. (183 aa) |
| | LOC113582774 | Small ubiquitin-related modifier. (94 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (590 aa) |
| | exo1 | Exonuclease 1. (771 aa) |
| | ENSEEEP00000019307 | Uncharacterized protein. (258 aa) |
| | LOC113582267 | Breast cancer 2, early onset. (2391 aa) |
| | ENSEEEP00000018543 | Methionine sulfoxide reductase B1b. (259 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (324 aa) |
| | polh | Polymerase (DNA directed), eta. (700 aa) |
| | timeless | Timeless circadian clock. (1201 aa) |
| | ENSEEEP00000017959 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (784 aa) |
| | ENSEEEP00000017953 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (368 aa) |
| | Pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (708 aa) |
| | ENSEEEP00000017941 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (304 aa) |
| | LOC113582257 | Uncharacterized protein. (414 aa) |
| | ENSEEEP00000017392 | PHD-type domain-containing protein. (245 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | atrip | ATR interacting protein. (763 aa) |
| | xrcc3 | RECA_2 domain-containing protein. (355 aa) |
| | eya2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (475 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1479 aa) |
| | LOC113590069 | Uncharacterized protein. (973 aa) |
| | ube2n | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1181 aa) |
| | rfc1 | Replication factor C subunit 1. (1124 aa) |
| | ENSEEEP00000013350 | Uncharacterized protein. (106 aa) |
| | ENSEEEP00000012918 | JmjN domain-containing protein. (236 aa) |
| | LOC113568370 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSEEEP00000012861 | Histone H2B; Belongs to the histone H2B family. (110 aa) |
| | dntt | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (499 aa) |
| | nhej1 | Uncharacterized protein. (325 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (322 aa) |
| | babam2 | Uncharacterized protein. (442 aa) |
| | tdp1 | Uncharacterized protein. (622 aa) |
| | LOC113589980 | Uncharacterized protein. (1051 aa) |
| | recql4 | RecQ helicase-like 4. (817 aa) |
| | cdca7l | Cell division cycle associated 7b. (425 aa) |
| | KPNA2 | Uncharacterized protein. (426 aa) |
| | LOC113583945 | Tyrosine-protein kinase. (1088 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa) |
| | rfc2 | AAA domain-containing protein. (369 aa) |
| | cdca7 | zf-4CXXC_R1 domain-containing protein. (406 aa) |
| | rps27a | Ubiquitin-like domain-containing protein. (156 aa) |
| | apbb1 | Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (696 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1002 aa) |
| | rif1 | Replication timing regulatory factor 1. (2379 aa) |
| | rad51d | RECA_2 domain-containing protein. (338 aa) |
| | lig3 | DNA ligase. (1009 aa) |
| | LOC113570959 | Uncharacterized protein. (443 aa) |
| | dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (683 aa) |
| | polq | Polymerase (DNA directed), theta. (2580 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (470 aa) |
| | Polk | Uncharacterized protein. (403 aa) |
| | polk | Polymerase (DNA directed) kappa. (413 aa) |
| | ENSEEEP00000007003 | AAA_23 domain-containing protein. (53 aa) |
| | ENSEEEP00000006834 | Uncharacterized protein. (110 aa) |
| | pold4 | Uncharacterized protein. (109 aa) |
| | cnppd1 | Cyclin Pas1/PHO80 domain containing 1. (413 aa) |
| | LOC113569275 | Serine/threonine-protein phosphatase. (247 aa) |
| | tdrd3 | Uncharacterized protein. (790 aa) |
| | sirt7 | Deacetylase sirtuin-type domain-containing protein. (405 aa) |
| | ENSEEEP00000005940 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | pold3 | Uncharacterized protein. (462 aa) |
| | LOC113569058 | AAA_23 domain-containing protein. (469 aa) |
| | LOC113569037 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | HIST1H2BF | Histone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa) |
| | LOC113568938 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | ENSEEEP00000005177 | Histone domain-containing protein; Belongs to the histone H2B family. (140 aa) |
