STRINGSTRING
LOC113567650 LOC113567650 LOC113571395 LOC113571395 ENSEEEP00000000319 ENSEEEP00000000319 ENSEEEP00000000649 ENSEEEP00000000649 LOC113569455 LOC113569455 ENSEEEP00000000760 ENSEEEP00000000760 rmi2 rmi2 rpa1 rpa1 LOC113583786 LOC113583786 LOC113567680 LOC113567680 LOC113573440 LOC113573440 pold1 pold1 exd2 exd2 rfc4 rfc4 rmi1 rmi1 ENSEEEP00000004035 ENSEEEP00000004035 LOC113568250 LOC113568250 sirt6 sirt6 LOC113568892 LOC113568892 LOC113568893 LOC113568893 ENSEEEP00000005177 ENSEEEP00000005177 LOC113568938 LOC113568938 HIST1H2BF HIST1H2BF LOC113569037 LOC113569037 LOC113569058 LOC113569058 pold3 pold3 ENSEEEP00000005940 ENSEEEP00000005940 sirt7 sirt7 tdrd3 tdrd3 pold4 pold4 ENSEEEP00000006834 ENSEEEP00000006834 ENSEEEP00000007003 ENSEEEP00000007003 polk polk Polk Polk chek1 chek1 LOC113570959 LOC113570959 rad51d rad51d DNA2 DNA2 rps27a rps27a cdca7 cdca7 rfc2 rfc2 nbn nbn top3a top3a LOC113583945 LOC113583945 cdca7l cdca7l recql4 recql4 babam2 babam2 ccna1 ccna1 ENSEEEP00000012861 ENSEEEP00000012861 LOC113568370 LOC113568370 ENSEEEP00000013350 ENSEEEP00000013350 rfc1 rfc1 rad50 rad50 ube2n ube2n topbp1 topbp1 xrcc3 xrcc3 atrip atrip rad51 rad51 LOC113582257 LOC113582257 ENSEEEP00000017941 ENSEEEP00000017941 Pole Pole ENSEEEP00000017953 ENSEEEP00000017953 ENSEEEP00000017959 ENSEEEP00000017959 timeless timeless polh polh cdk2 cdk2 ENSEEEP00000018543 ENSEEEP00000018543 LOC113582267 LOC113582267 ENSEEEP00000019307 ENSEEEP00000019307 exo1 exo1 rfc5 rfc5 spidr spidr ube2v2 ube2v2 rfc3 rfc3 ENSEEEP00000023290 ENSEEEP00000023290 LOC113578458 LOC113578458 rpa3 rpa3 LOC113576955 LOC113576955 mre11 mre11 pcna pcna LOC113577231 LOC113577231 rnf8 rnf8 ENSEEEP00000028715 ENSEEEP00000028715 LOC113589524 LOC113589524 pias4 pias4 ENSEEEP00000029755 ENSEEEP00000029755 LOC113579037 LOC113579037 slf1 slf1 babam1 babam1 pole4 pole4 abraxas1 abraxas1 pole3 pole3 rad9a rad9a ENSEEEP00000032310 ENSEEEP00000032310 ccna2 ccna2 LOC113572424 LOC113572424 atr atr rad51ap1 rad51ap1 ENSEEEP00000034862 ENSEEEP00000034862 rbbp8 rbbp8 blm blm ENSEEEP00000035351 ENSEEEP00000035351 rad17 rad17 ENSEEEP00000036356 ENSEEEP00000036356 LOC113574589 LOC113574589 LOC113577337 LOC113577337 ENSEEEP00000039231 ENSEEEP00000039231 LOC113569449 LOC113569449 XRCC2 XRCC2 ppp4c ppp4c pold2 pold2 ankrd11 ankrd11 LOC113578639 LOC113578639 mus81 mus81 tipin tipin hus1 hus1 brcc3 brcc3 ENSEEEP00000043756 ENSEEEP00000043756 sumo2 sumo2 uimc1 uimc1 rpa2 rpa2 LOC113584157 LOC113584157 SUMO3 SUMO3 Nsd2 Nsd2 ENSEEEP00000045899 ENSEEEP00000045899 kxd1 kxd1 LOC113582774 LOC113582774 rad52 rad52 ENSEEEP00000047072 ENSEEEP00000047072 LOC113576847 LOC113576847 ankrd12 ankrd12 uba52 uba52 LOC113577499 LOC113577499 ENSEEEP00000049401 ENSEEEP00000049401 LOC113583736 LOC113583736 Rnf169 Rnf169 rnf168 rnf168 ENSEEEP00000050839 ENSEEEP00000050839 rhno1 rhno1 eme1 eme1 rad1 rad1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC113567650Uncharacterized protein. (1631 aa)
LOC113571395Polymerase (DNA directed), epsilon 2. (527 aa)
ENSEEEP00000000319Histone domain-containing protein; Belongs to the histone H2B family. (104 aa)
ENSEEEP00000000649Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
LOC113569455Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSEEEP00000000760Histone H2B; Belongs to the histone H2B family. (115 aa)
rmi2Uncharacterized protein. (147 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
LOC113583786Histone H2B; Belongs to the histone H2B family. (117 aa)
LOC113567680Small ubiquitin-related modifier. (109 aa)
LOC113573440UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
pold1DNA polymerase. (1061 aa)
exd2Exonuclease 3'-5' domain containing 2. (616 aa)
rfc4AAA domain-containing protein. (357 aa)
rmi1DUF1767 domain-containing protein. (587 aa)
ENSEEEP00000004035Dpoe2NT domain-containing protein. (82 aa)
LOC113568250RAD51 paralog C. (260 aa)
sirt6Deacetylase sirtuin-type domain-containing protein. (396 aa)
LOC113568892Histone H2B; Belongs to the histone H2B family. (64 aa)
LOC113568893Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSEEEP00000005177Histone domain-containing protein; Belongs to the histone H2B family. (140 aa)
LOC113568938Histone H2A; Belongs to the histone H2A family. (115 aa)
HIST1H2BFHistone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa)
LOC113569037Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
pold3Uncharacterized protein. (462 aa)
ENSEEEP00000005940Histone H2B; Belongs to the histone H2B family. (131 aa)
sirt7Deacetylase sirtuin-type domain-containing protein. (405 aa)
tdrd3Uncharacterized protein. (790 aa)
pold4Uncharacterized protein. (109 aa)
ENSEEEP00000006834Uncharacterized protein. (110 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
polkPolymerase (DNA directed) kappa. (413 aa)
PolkUncharacterized protein. (403 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (470 aa)
LOC113570959Uncharacterized protein. (443 aa)
rad51dRECA_2 domain-containing protein. (338 aa)
DNA2DNA replication helicase/nuclease 2. (1002 aa)
rps27aUbiquitin-like domain-containing protein. (156 aa)
cdca7zf-4CXXC_R1 domain-containing protein. (406 aa)
rfc2AAA domain-containing protein. (369 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
LOC113583945Tyrosine-protein kinase. (1088 aa)
cdca7lCell division cycle associated 7b. (425 aa)
recql4RecQ helicase-like 4. (817 aa)
babam2Uncharacterized protein. (442 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (322 aa)
ENSEEEP00000012861Histone H2B; Belongs to the histone H2B family. (110 aa)
LOC113568370Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSEEEP00000013350Uncharacterized protein. (106 aa)
rfc1Replication factor C subunit 1. (1124 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
topbp1DNA topoisomerase II binding protein 1. (1479 aa)
xrcc3RECA_2 domain-containing protein. (355 aa)
atripATR interacting protein. (763 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
LOC113582257Uncharacterized protein. (414 aa)
ENSEEEP00000017941DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (304 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (708 aa)
ENSEEEP00000017953DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (368 aa)
ENSEEEP00000017959ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (784 aa)
timelessTimeless circadian clock. (1201 aa)
polhPolymerase (DNA directed), eta. (700 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (324 aa)
ENSEEEP00000018543Methionine sulfoxide reductase B1b. (259 aa)
LOC113582267Breast cancer 2, early onset. (2391 aa)
ENSEEEP00000019307Uncharacterized protein. (258 aa)
exo1Exonuclease 1. (771 aa)
rfc5AAA domain-containing protein. (363 aa)
spidrDUF4503 domain-containing protein. (573 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa)
rfc3AAA domain-containing protein. (356 aa)
ENSEEEP00000023290RAD9 checkpoint clamp component B. (181 aa)
LOC113578458UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
rpa3Uncharacterized protein. (122 aa)
LOC113576955Histone H2A; Belongs to the histone H2A family. (140 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC113577231RPA_C domain-containing protein. (232 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa)
ENSEEEP00000028715Uncharacterized protein. (420 aa)
LOC113589524RECA_2 domain-containing protein. (121 aa)
pias4Protein inhibitor of activated STAT, 4a. (503 aa)
ENSEEEP00000029755Histone H2A; Belongs to the histone H2A family. (140 aa)
LOC113579037Histone H2B; Belongs to the histone H2B family. (139 aa)
slf1ANK_REP_REGION domain-containing protein. (905 aa)
babam1Uncharacterized protein. (359 aa)
pole4CBFD_NFYB_HMF domain-containing protein. (127 aa)
abraxas1MPN domain-containing protein. (419 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (149 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
ccna2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
LOC113572424Ubiquitin-conjugating enzyme E2 variant 1. (176 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2627 aa)
rad51ap1RAD51_interact domain-containing protein. (230 aa)
ENSEEEP00000034862Protein inhibitor of activated STAT, 4b. (419 aa)
rbbp8SAE2 domain-containing protein. (131 aa)
blmBLM RecQ like helicase. (1281 aa)
ENSEEEP00000035351Endo/exonuclease/phosphatase domain-containing protein. (429 aa)
rad17Uncharacterized protein. (683 aa)
ENSEEEP00000036356Histone H2A; Belongs to the histone H2A family. (158 aa)
LOC113574589HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa)
LOC113577337Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (263 aa)
ENSEEEP00000039231Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
LOC113569449Histone H4. (103 aa)
XRCC2RECA_2 domain-containing protein. (302 aa)
ppp4cSerine/threonine-protein phosphatase. (307 aa)
pold2Uncharacterized protein. (469 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2837 aa)
LOC113578639Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (528 aa)
mus81MUS81 structure-specific endonuclease subunit. (615 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (305 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (283 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (269 aa)
ENSEEEP00000043756XPGI domain-containing protein. (341 aa)
sumo2Small ubiquitin-related modifier. (111 aa)
uimc1RAP80_UIM domain-containing protein. (953 aa)
rpa2RPA_C domain-containing protein. (280 aa)
LOC113584157Ubiquitin-like domain-containing protein. (77 aa)
SUMO3Small ubiquitin-related modifier. (113 aa)
Nsd2Uncharacterized protein. (603 aa)
ENSEEEP00000045899PWWP domain-containing protein. (460 aa)
kxd1KxDL domain-containing protein. (183 aa)
LOC113582774Small ubiquitin-related modifier. (94 aa)
rad52RAD52 homolog, DNA repair protein. (287 aa)
ENSEEEP00000047072Uncharacterized protein. (332 aa)
LOC113576847RING-type domain-containing protein. (995 aa)
ankrd12ANK_REP_REGION domain-containing protein. (419 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
LOC113577499Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (549 aa)
ENSEEEP00000049401Histone H2B; Belongs to the histone H2B family. (134 aa)
LOC113583736UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (246 aa)
Rnf169RING-type domain-containing protein. (106 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
rhno1Uncharacterized protein. (308 aa)
eme1Essential meiotic structure-specific endonuclease 1. (550 aa)
rad1Uncharacterized protein. (279 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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