STRINGSTRING
rif1 rif1 ENSEEEP00000000086 ENSEEEP00000000086 LOC113567650 LOC113567650 ENSEEEP00000000319 ENSEEEP00000000319 ENSEEEP00000000649 ENSEEEP00000000649 LOC113569455 LOC113569455 ENSEEEP00000000760 ENSEEEP00000000760 LOC113583786 LOC113583786 paxip1 paxip1 LOC113591092 LOC113591092 LOC113568892 LOC113568892 LOC113568893 LOC113568893 ENSEEEP00000005177 ENSEEEP00000005177 LOC113568938 LOC113568938 HIST1H2BF HIST1H2BF LOC113569037 LOC113569037 LOC113569058 LOC113569058 ENSEEEP00000005940 ENSEEEP00000005940 cnppd1 cnppd1 ENSEEEP00000007003 ENSEEEP00000007003 dclre1c dclre1c nbn nbn tdp1 tdp1 nhej1 nhej1 dntt dntt ENSEEEP00000012861 ENSEEEP00000012861 LOC113568370 LOC113568370 rad50 rad50 ube2n ube2n ube2v2 ube2v2 xrcc6 xrcc6 LOC113576955 LOC113576955 lig4 lig4 mre11 mre11 poll poll rnf8 rnf8 ENSEEEP00000028715 ENSEEEP00000028715 pias4 pias4 ENSEEEP00000029755 ENSEEEP00000029755 LOC113579037 LOC113579037 ENSEEEP00000032310 ENSEEEP00000032310 LOC113572424 LOC113572424 ENSEEEP00000034862 ENSEEEP00000034862 ENSEEEP00000035351 ENSEEEP00000035351 ENSEEEP00000036356 ENSEEEP00000036356 LOC113567584 LOC113567584 LOC113574589 LOC113574589 LOC113574046 LOC113574046 ENSEEEP00000039231 ENSEEEP00000039231 LOC113569449 LOC113569449 ankrd11 ankrd11 xrcc5 xrcc5 xrcc4 xrcc4 polm polm Nsd2 Nsd2 ENSEEEP00000045899 ENSEEEP00000045899 ENSEEEP00000047072 ENSEEEP00000047072 LOC113576847 LOC113576847 ankrd12 ankrd12 LOC113572244 LOC113572244 ENSEEEP00000049401 ENSEEEP00000049401 Rnf169 Rnf169 rnf168 rnf168 ENSEEEP00000050839 ENSEEEP00000050839 prkdc prkdc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rif1Replication timing regulatory factor 1. (2379 aa)
ENSEEEP00000000086Uncharacterized protein. (247 aa)
LOC113567650Uncharacterized protein. (1631 aa)
ENSEEEP00000000319Histone domain-containing protein; Belongs to the histone H2B family. (104 aa)
ENSEEEP00000000649Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
LOC113569455Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSEEEP00000000760Histone H2B; Belongs to the histone H2B family. (115 aa)
LOC113583786Histone H2B; Belongs to the histone H2B family. (117 aa)
paxip1PAX interacting (with transcription-activation domain) protein 1. (1107 aa)
LOC113591092Uncharacterized protein. (242 aa)
LOC113568892Histone H2B; Belongs to the histone H2B family. (64 aa)
LOC113568893Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSEEEP00000005177Histone domain-containing protein; Belongs to the histone H2B family. (140 aa)
LOC113568938Histone H2A; Belongs to the histone H2A family. (115 aa)
HIST1H2BFHistone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa)
LOC113569037Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
ENSEEEP00000005940Histone H2B; Belongs to the histone H2B family. (131 aa)
cnppd1Cyclin Pas1/PHO80 domain containing 1. (413 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (683 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
tdp1Uncharacterized protein. (622 aa)
nhej1Uncharacterized protein. (325 aa)
dnttDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (499 aa)
ENSEEEP00000012861Histone H2B; Belongs to the histone H2B family. (110 aa)
LOC113568370Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa)
xrcc6Uncharacterized protein. (627 aa)
LOC113576955Histone H2A; Belongs to the histone H2A family. (140 aa)
lig4DNA ligase. (909 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa)
ENSEEEP00000028715Uncharacterized protein. (420 aa)
pias4Protein inhibitor of activated STAT, 4a. (503 aa)
ENSEEEP00000029755Histone H2A; Belongs to the histone H2A family. (140 aa)
LOC113579037Histone H2B; Belongs to the histone H2B family. (139 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
LOC113572424Ubiquitin-conjugating enzyme E2 variant 1. (176 aa)
ENSEEEP00000034862Protein inhibitor of activated STAT, 4b. (419 aa)
ENSEEEP00000035351Endo/exonuclease/phosphatase domain-containing protein. (429 aa)
ENSEEEP00000036356Histone H2A; Belongs to the histone H2A family. (158 aa)
LOC113567584Uncharacterized protein. (377 aa)
LOC113574589HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa)
LOC113574046Transmembrane protein 182b. (252 aa)
ENSEEEP00000039231Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
LOC113569449Histone H4. (103 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2837 aa)
xrcc5Ku domain-containing protein. (740 aa)
xrcc4Uncharacterized protein. (343 aa)
polmDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (503 aa)
Nsd2Uncharacterized protein. (603 aa)
ENSEEEP00000045899PWWP domain-containing protein. (460 aa)
ENSEEEP00000047072Uncharacterized protein. (332 aa)
LOC113576847RING-type domain-containing protein. (995 aa)
ankrd12ANK_REP_REGION domain-containing protein. (419 aa)
LOC113572244Endo/exonuclease/phosphatase domain-containing protein. (409 aa)
ENSEEEP00000049401Histone H2B; Belongs to the histone H2B family. (134 aa)
Rnf169RING-type domain-containing protein. (106 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4099 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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