STRINGSTRING
uimc1 uimc1 brcc3 brcc3 LOC113577352 LOC113577352 LOC113575217 LOC113575217 ankrd11 ankrd11 LOC113569449 LOC113569449 ENSEEEP00000039231 ENSEEEP00000039231 LOC113574589 LOC113574589 ENSEEEP00000036356 ENSEEEP00000036356 ENSEEEP00000035351 ENSEEEP00000035351 eya4 eya4 ENSEEEP00000034862 ENSEEEP00000034862 tp53 tp53 LOC113572424 LOC113572424 ENSEEEP00000032310 ENSEEEP00000032310 abraxas1 abraxas1 LOC113573440 LOC113573440 LOC113583786 LOC113583786 ENSEEEP00000001112 ENSEEEP00000001112 ENSEEEP00000000760 ENSEEEP00000000760 LOC113569455 LOC113569455 ENSEEEP00000000649 ENSEEEP00000000649 ENSEEEP00000000319 ENSEEEP00000000319 LOC113567650 LOC113567650 babam1 babam1 LOC113591480 LOC113591480 mre11 mre11 LOC113576955 LOC113576955 LOC113578458 LOC113578458 LOC113579037 LOC113579037 ENSEEEP00000029755 ENSEEEP00000029755 ENSEEEP00000004593 ENSEEEP00000004593 ENSEEEP00000004594 ENSEEEP00000004594 LOC113568892 LOC113568892 pias4 pias4 ENSEEEP00000028715 ENSEEEP00000028715 rnf8 rnf8 LOC113581660 LOC113581660 LOC113568370 LOC113568370 ENSEEEP00000012861 ENSEEEP00000012861 babam2 babam2 LOC113589980 LOC113589980 KPNA2 KPNA2 LOC113583945 LOC113583945 nbn nbn rps27a rps27a ENSEEEP00000012918 ENSEEEP00000012918 rad50 rad50 LOC113568893 LOC113568893 ENSEEEP00000005177 ENSEEEP00000005177 sumo1 sumo1 LOC113568938 LOC113568938 HIST1H2BF HIST1H2BF LOC113569037 LOC113569037 LOC113569058 LOC113569058 ENSEEEP00000005940 ENSEEEP00000005940 LOC113569275 LOC113569275 ENSEEEP00000007003 ENSEEEP00000007003 apbb1 apbb1 ube2v2 ube2v2 eya1 eya1 ENSEEEP00000017392 ENSEEEP00000017392 eya2 eya2 LOC113590069 LOC113590069 ube2n ube2n ENSEEEP00000051054 ENSEEEP00000051054 ENSEEEP00000050839 ENSEEEP00000050839 rnf168 rnf168 Rnf169 Rnf169 LOC113583736 LOC113583736 ENSEEEP00000049401 ENSEEEP00000049401 uba52 uba52 baz1b baz1b ankrd12 ankrd12 chek2 chek2 LOC113576847 LOC113576847 ENSEEEP00000047072 ENSEEEP00000047072 kxd1 kxd1 ENSEEEP00000045899 ENSEEEP00000045899 Nsd2 Nsd2 LOC113584157 LOC113584157
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uimc1RAP80_UIM domain-containing protein. (953 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (269 aa)
LOC113577352Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (366 aa)
LOC113575217Importin subunit alpha; Belongs to the importin alpha family. (526 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2837 aa)
LOC113569449Histone H4. (103 aa)
ENSEEEP00000039231Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
LOC113574589HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa)
ENSEEEP00000036356Histone H2A; Belongs to the histone H2A family. (158 aa)
ENSEEEP00000035351Endo/exonuclease/phosphatase domain-containing protein. (429 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (603 aa)
ENSEEEP00000034862Protein inhibitor of activated STAT, 4b. (419 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
LOC113572424Ubiquitin-conjugating enzyme E2 variant 1. (176 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
abraxas1MPN domain-containing protein. (419 aa)
LOC113573440UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
LOC113583786Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSEEEP00000001112IBB domain-containing protein. (80 aa)
ENSEEEP00000000760Histone H2B; Belongs to the histone H2B family. (115 aa)
LOC113569455Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSEEEP00000000649Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSEEEP00000000319Histone domain-containing protein; Belongs to the histone H2B family. (104 aa)
LOC113567650Uncharacterized protein. (1631 aa)
babam1Uncharacterized protein. (359 aa)
LOC113591480Lysine (K)-specific demethylase 4A, genome duplicate b. (917 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
LOC113576955Histone H2A; Belongs to the histone H2A family. (140 aa)
LOC113578458UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
LOC113579037Histone H2B; Belongs to the histone H2B family. (139 aa)
ENSEEEP00000029755Histone H2A; Belongs to the histone H2A family. (140 aa)
ENSEEEP00000004593TPR_REGION domain-containing protein. (132 aa)
ENSEEEP00000004594TPR_REGION domain-containing protein. (124 aa)
LOC113568892Histone H2B; Belongs to the histone H2B family. (64 aa)
pias4Protein inhibitor of activated STAT, 4a. (503 aa)
ENSEEEP00000028715Uncharacterized protein. (420 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa)
LOC113581660Importin subunit alpha; Belongs to the importin alpha family. (508 aa)
LOC113568370Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSEEEP00000012861Histone H2B; Belongs to the histone H2B family. (110 aa)
babam2Uncharacterized protein. (442 aa)
LOC113589980Uncharacterized protein. (1051 aa)
KPNA2Uncharacterized protein. (426 aa)
LOC113583945Tyrosine-protein kinase. (1088 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
rps27aUbiquitin-like domain-containing protein. (156 aa)
ENSEEEP00000012918JmjN domain-containing protein. (236 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
LOC113568893Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSEEEP00000005177Histone domain-containing protein; Belongs to the histone H2B family. (140 aa)
sumo1Small ubiquitin-related modifier. (121 aa)
LOC113568938Histone H2A; Belongs to the histone H2A family. (115 aa)
HIST1H2BFHistone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa)
LOC113569037Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC113569058AAA_23 domain-containing protein. (469 aa)
ENSEEEP00000005940Histone H2B; Belongs to the histone H2B family. (131 aa)
LOC113569275Serine/threonine-protein phosphatase. (247 aa)
ENSEEEP00000007003AAA_23 domain-containing protein. (53 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (696 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (590 aa)
ENSEEEP00000017392PHD-type domain-containing protein. (245 aa)
eya2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (475 aa)
LOC113590069Uncharacterized protein. (973 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSEEEP00000051054Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (307 aa)
ENSEEEP00000050839Metallophos domain-containing protein. (106 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa)
Rnf169RING-type domain-containing protein. (106 aa)
LOC113583736UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (246 aa)
ENSEEEP00000049401Histone H2B; Belongs to the histone H2B family. (134 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1577 aa)
ankrd12ANK_REP_REGION domain-containing protein. (419 aa)
chek2Uncharacterized protein. (526 aa)
LOC113576847RING-type domain-containing protein. (995 aa)
ENSEEEP00000047072Uncharacterized protein. (332 aa)
kxd1KxDL domain-containing protein. (183 aa)
ENSEEEP00000045899PWWP domain-containing protein. (460 aa)
Nsd2Uncharacterized protein. (603 aa)
LOC113584157Ubiquitin-like domain-containing protein. (77 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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