Your Input: | |
| | LOC113587655 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | ywhae | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | rad1 | Uncharacterized protein. (279 aa) |
| | rhno1 | Uncharacterized protein. (308 aa) |
| | ENSEEEP00000050839 | Metallophos domain-containing protein. (106 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa) |
| | LOC113585421 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | Rnf169 | RING-type domain-containing protein. (106 aa) |
| | ENSEEEP00000049401 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (419 aa) |
| | chek2 | Uncharacterized protein. (526 aa) |
| | LOC113576847 | RING-type domain-containing protein. (995 aa) |
| | ENSEEEP00000047072 | Uncharacterized protein. (332 aa) |
| | ENSEEEP00000045899 | PWWP domain-containing protein. (460 aa) |
| | Nsd2 | Uncharacterized protein. (603 aa) |
| | wee2 | Wee1-like protein kinase. (542 aa) |
| | rpa2 | RPA_C domain-containing protein. (280 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (953 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (269 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | LOC113577352 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (366 aa) |
| | ankrd11 | ANK_REP_REGION domain-containing protein. (2837 aa) |
| | LOC113569449 | Histone H4. (103 aa) |
| | ENSEEEP00000039231 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | LOC113574589 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa) |
| | LOC113575643 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (242 aa) |
| | ENSEEEP00000036356 | Histone H2A; Belongs to the histone H2A family. (158 aa) |
| | rad17 | Uncharacterized protein. (683 aa) |
| | ENSEEEP00000035351 | Endo/exonuclease/phosphatase domain-containing protein. (429 aa) |
| | blm | BLM RecQ like helicase. (1281 aa) |
| | rbbp8 | SAE2 domain-containing protein. (131 aa) |
| | ENSEEEP00000034862 | Protein inhibitor of activated STAT, 4b. (419 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2627 aa) |
| | LOC113575130 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | LOC113572424 | Ubiquitin-conjugating enzyme E2 variant 1. (176 aa) |
| | ENSEEEP00000032310 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa) |
| | WEE1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa) |
| | abraxas1 | MPN domain-containing protein. (419 aa) |
| | babam1 | Uncharacterized protein. (359 aa) |
| | slf1 | ANK_REP_REGION domain-containing protein. (905 aa) |
| | LOC113579037 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | ENSEEEP00000029755 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (503 aa) |
| | ENSEEEP00000028715 | Uncharacterized protein. (420 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | LOC113577231 | RPA_C domain-containing protein. (232 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | LOC113576955 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | ENSEEEP00000023290 | RAD9 checkpoint clamp component B. (181 aa) |
| | rfc3 | AAA domain-containing protein. (356 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa) |
| | ywhaq | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | ccnb1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (396 aa) |
| | LOC113582289 | Protein kinase domain-containing protein. (667 aa) |
| | rfc5 | AAA domain-containing protein. (363 aa) |
| | exo1 | Exonuclease 1. (771 aa) |
| | ENSEEEP00000018543 | Methionine sulfoxide reductase B1b. (259 aa) |
| | ENSEEEP00000017959 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (784 aa) |
| | atrip | ATR interacting protein. (763 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1479 aa) |
| | ube2n | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1181 aa) |
| | ENSEEEP00000013350 | Uncharacterized protein. (106 aa) |
| | LOC113568370 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSEEEP00000012861 | Histone H2B; Belongs to the histone H2B family. (110 aa) |
| | babam2 | Uncharacterized protein. (442 aa) |
| | recql4 | RecQ helicase-like 4. (817 aa) |
| | cdca7l | Cell division cycle associated 7b. (425 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa) |
| | rfc2 | AAA domain-containing protein. (369 aa) |
| | cdca7 | zf-4CXXC_R1 domain-containing protein. (406 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1002 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (470 aa) |
| | LOC113582105 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (265 aa) |
| | ENSEEEP00000007003 | AAA_23 domain-containing protein. (53 aa) |
| | tdrd3 | Uncharacterized protein. (790 aa) |
| | ENSEEEP00000005940 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | LOC113569058 | AAA_23 domain-containing protein. (469 aa) |
| | LOC113569037 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | HIST1H2BF | Histone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa) |
| | LOC113568938 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | ENSEEEP00000005177 | Histone domain-containing protein; Belongs to the histone H2B family. (140 aa) |
| | LOC113568893 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC113568892 | Histone H2B; Belongs to the histone H2B family. (64 aa) |
| | LOC113574213 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | LOC113579860 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | LOC113578772 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa) |
| | rmi1 | DUF1767 domain-containing protein. (587 aa) |
| | rfc4 | AAA domain-containing protein. (357 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (616 aa) |
| | cdk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | LOC113583786 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa) |
| | rmi2 | Uncharacterized protein. (147 aa) |
| | ENSEEEP00000000760 | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | LOC113569455 | Histone H2B; Belongs to the histone H2B family. (67 aa) |
| | ENSEEEP00000000649 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSEEEP00000000319 | Histone domain-containing protein; Belongs to the histone H2B family. (104 aa) |
| | LOC113567650 | Uncharacterized protein. (1631 aa) |
| | LOC113577545 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (245 aa) |
| | CDC25B | Cell division cycle 25B. (551 aa) |
