Your Input: | |
| | ywhae | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | wdr41 | WD_REPEATS_REGION domain-containing protein. (454 aa) |
| | rad1 | Uncharacterized protein. (279 aa) |
| | orc5 | AAA_16 domain-containing protein. (444 aa) |
| | rhno1 | Uncharacterized protein. (308 aa) |
| | ENSEEEP00000050839 | Metallophos domain-containing protein. (106 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (471 aa) |
| | LOC113585421 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (908 aa) |
| | Rnf169 | RING-type domain-containing protein. (106 aa) |
| | psmd9 | PDZ domain-containing protein. (213 aa) |
| | ENSEEEP00000049401 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | psmc5 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | LOC113577499 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (549 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (419 aa) |
| | LOC113581944 | Piezo-type mechanosensitive ion channel component. (2674 aa) |
| | LOC113581273 | Proteasome subunit beta. (218 aa) |
| | LOC113581261 | Proteasome subunit beta. (238 aa) |
| | LOC113581270 | Proteasome subunit beta. (281 aa) |
| | pkmyt1 | Protein kinase domain-containing protein. (605 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (830 aa) |
| | chek2 | Uncharacterized protein. (526 aa) |
| | LOC113576847 | RING-type domain-containing protein. (995 aa) |
| | ENSEEEP00000047072 | Uncharacterized protein. (332 aa) |
| | kxd1 | KxDL domain-containing protein. (183 aa) |
| | orc2 | Origin recognition complex, subunit 2. (491 aa) |
| | ENSEEEP00000045899 | PWWP domain-containing protein. (460 aa) |
| | Nsd2 | Uncharacterized protein. (603 aa) |
| | gtse1 | G-2 and S-phase expressed 1. (729 aa) |
| | wee2 | Wee1-like protein kinase. (542 aa) |
| | LOC113571385 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | rpa2 | RPA_C domain-containing protein. (280 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (953 aa) |
| | LOC113582857 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (411 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (269 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | psme2 | Uncharacterized protein. (241 aa) |
| | LOC113577352 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (366 aa) |
| | psmd8 | Proteasome 26S subunit, non-ATPase 8. (280 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa) |
| | piezo1 | Piezo-type mechanosensitive ion channel component. (2445 aa) |
| | LOC113578639 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (528 aa) |
| | psma3 | Proteasome subunit alpha type. (255 aa) |
| | LOC113589194 | Proteasome subunit beta. (270 aa) |
| | ankrd11 | ANK_REP_REGION domain-containing protein. (2837 aa) |
| | ENSEEEP00000040942 | Proteasome subunit beta. (265 aa) |
| | psmd12 | PCI domain-containing protein. (479 aa) |
| | LOC113569449 | Histone H4. (103 aa) |
| | ENSEEEP00000039231 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | LOC113574589 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4800 aa) |
| | psmb3 | Proteasome subunit beta. (205 aa) |
| | ccnb2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (382 aa) |
| | psma4 | Proteasome subunit alpha type. (261 aa) |
| | LOC113567554 | Proteasome 26S subunit, non-ATPase 13. (366 aa) |
| | LOC113575643 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (242 aa) |
| | ENSEEEP00000036356 | Histone H2A; Belongs to the histone H2A family. (158 aa) |
| | rad17 | Uncharacterized protein. (683 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (543 aa) |
| | psmd3 | PCI domain-containing protein. (514 aa) |
| | ENSEEEP00000035351 | Endo/exonuclease/phosphatase domain-containing protein. (429 aa) |
| | psmd10 | ANK_REP_REGION domain-containing protein. (233 aa) |
| | blm | BLM RecQ like helicase. (1281 aa) |
| | rbbp8 | SAE2 domain-containing protein. (131 aa) |
| | ENSEEEP00000034862 | Protein inhibitor of activated STAT, 4b. (419 aa) |
| | ENSEEEP00000034549 | Proteasome endopeptidase complex. (216 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2627 aa) |
| | LOC113575130 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | LOC113572424 | Ubiquitin-conjugating enzyme E2 variant 1. (176 aa) |
| | ENSEEEP00000032310 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa) |
| | LOC113589639 | PCI domain-containing protein. (432 aa) |
| | WEE1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa) |
| | psmd7 | Proteasome 26S subunit, non-ATPase 7. (327 aa) |
| | abraxas1 | MPN domain-containing protein. (419 aa) |
| | psmd14 | MPN domain-containing protein. (330 aa) |
| | babam1 | Uncharacterized protein. (359 aa) |
| | slf1 | ANK_REP_REGION domain-containing protein. (905 aa) |
| | cntd2 | Si:ch211-132b12.8; Belongs to the cyclin family. (393 aa) |
| | ENSEEEP00000029983 | Piezo-type mechanosensitive ion channel component. (2126 aa) |
| | LOC113579037 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | ENSEEEP00000029755 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | psmd1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (992 aa) |
| | psmb4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (255 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (503 aa) |
| | ENSEEEP00000028715 | Uncharacterized protein. (420 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | LOC113577231 | RPA_C domain-containing protein. (232 aa) |
| | psmc3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa) |
| | orc6 | Uncharacterized protein. (262 aa) |
| | psma6 | Proteasome subunit alpha type. (265 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | LOC113576955 | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | psme3 | Uncharacterized protein. (256 aa) |
| | psmc4 | AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa) |
| | cdc7 | Protein kinase domain-containing protein. (555 aa) |
| | ENSEEEP00000023290 | RAD9 checkpoint clamp component B. (181 aa) |
| | rfc3 | AAA domain-containing protein. (356 aa) |
| | psmc6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (848 aa) |
| | cdc45 | Uncharacterized protein. (574 aa) |
| | psmc2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (483 aa) |
| | psmb7 | Proteasome subunit beta. (277 aa) |
| | LOC113571724 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | ywhaq | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | LOC113571685 | Proteasome subunit alpha type. (246 aa) |
| | psmd5 | Proteasome 26S subunit, non-ATPase 5. (600 aa) |
| | ccnb1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (396 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (472 aa) |
| | LOC113582289 | Protein kinase domain-containing protein. (667 aa) |
| | rfc5 | AAA domain-containing protein. (363 aa) |
| | mcm8 | MCM domain-containing protein; Belongs to the MCM family. (844 aa) |
| | psma5 | Proteasome subunit alpha type. (241 aa) |
| | exo1 | Exonuclease 1. (771 aa) |
| | orc3 | Origin recognition complex, subunit 3. (723 aa) |
| | LOC113586778 | Proteasome subunit alpha type. (268 aa) |
| | ENSEEEP00000018543 | Methionine sulfoxide reductase B1b. (259 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (324 aa) |
| | psmb1 | Proteasome subunit beta. (243 aa) |
| | ENSEEEP00000017959 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (784 aa) |
| | psme4 | Proteasome activator subunit 4a. (1820 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (893 aa) |
| | atrip | ATR interacting protein. (763 aa) |
| | psmd6 | PCI domain-containing protein. (389 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | LOC113574752 | Piezo-type mechanosensitive ion channel component. (2577 aa) |
| | psmb2 | Proteasome subunit beta. (199 aa) |
| | CLSPN | Claspin. (1007 aa) |
| | mcm10 | Mcm10 domain-containing protein. (838 aa) |
| | mcm9 | MCM domain-containing protein; Belongs to the MCM family. (1143 aa) |
| | psme1 | Uncharacterized protein. (250 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1479 aa) |
| | ube2n | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1181 aa) |
| | ENSEEEP00000013350 | Uncharacterized protein. (106 aa) |
| | psmd4 | VWFA domain-containing protein. (373 aa) |
| | LOC113568370 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | ENSEEEP00000012861 | Histone H2B; Belongs to the histone H2B family. (110 aa) |
| | babam2 | Uncharacterized protein. (442 aa) |
| | recql4 | RecQ helicase-like 4. (817 aa) |
| | cdca7l | Cell division cycle associated 7b. (425 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa) |
| | rfc2 | AAA domain-containing protein. (369 aa) |
| | cdca7 | zf-4CXXC_R1 domain-containing protein. (406 aa) |
| | LOC113577646 | Uncharacterized protein. (1820 aa) |
| | rps27a | Ubiquitin-like domain-containing protein. (156 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1002 aa) |
| | LOC113587679 | Uncharacterized protein; Belongs to the cyclin family. (405 aa) |
| | psma2 | Proteasome subunit alpha type. (234 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (470 aa) |
| | dbf4 | DBF4 zinc finger. (660 aa) |
| | LOC113582105 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (265 aa) |
| | LOC113587655 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | ENSEEEP00000007003 | AAA_23 domain-containing protein. (53 aa) |
| | tdrd3 | Uncharacterized protein. (790 aa) |
| | ENSEEEP00000006326 | Proteasome subunit beta11b. (431 aa) |
| | LOC113583840 | Proteasome subunit beta. (279 aa) |
| | ENSEEEP00000005940 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | LOC113569058 | AAA_23 domain-containing protein. (469 aa) |
| | LOC113569037 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | HIST1H2BF | Histone cluster 1 H2B family member f; Belongs to the histone H2B family. (110 aa) |
| | LOC113568938 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | ENSEEEP00000005177 | Histone domain-containing protein; Belongs to the histone H2B family. (140 aa) |
| | LOC113568893 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC113568892 | Histone H2B; Belongs to the histone H2B family. (64 aa) |
| | LOC113591075 | Proteasome subunit beta. (233 aa) |
| | psmf1 | Uncharacterized protein. (272 aa) |
| | LOC113574213 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa) |
| | LOC113588778 | Proteasome 26S subunit, non-ATPase 11a. (449 aa) |
| | LOC113579860 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | LOC113578772 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa) |
| | rmi1 | DUF1767 domain-containing protein. (587 aa) |
| | psma1 | Proteasome subunit alpha type. (262 aa) |
| | rfc4 | AAA domain-containing protein. (357 aa) |
| | LOC113584344 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | LOC113592042 | Proteasome subunit beta. (236 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (616 aa) |
| | cdk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | LOC113583786 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa) |
| | LOC113585995 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | rmi2 | Uncharacterized protein. (147 aa) |
| | ENSEEEP00000000760 | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | LOC113569455 | Histone H2B; Belongs to the histone H2B family. (67 aa) |
| | ENSEEEP00000000649 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | LOC113578388 | PCI domain-containing protein. (385 aa) |
| | LOC113585437 | Proteasome subunit alpha type. (246 aa) |
| | ENSEEEP00000000319 | Histone domain-containing protein; Belongs to the histone H2B family. (104 aa) |
| | LOC113567650 | Uncharacterized protein. (1631 aa) |
| | LOC113577545 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (245 aa) |
| | CDC25B | Cell division cycle 25B. (551 aa) |
