(33 nodes) Base excision repair network (Electrophorus electricus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113571395	Polymerase (DNA directed), epsilon 2. (527 aa)
	ogg1	8-oxoguanine DNA glycosylase. (389 aa)
	pold1	DNA polymerase. (1061 aa)
	mpg	Uncharacterized protein. (286 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (312 aa)
	Neil1	Nei-like DNA glycosylase 1. (152 aa)
	hmgb1	High mobility group box 1a. (209 aa)
	pold3	Uncharacterized protein. (462 aa)
	pold4	Uncharacterized protein. (109 aa)
	lig3	DNA ligase. (1009 aa)
	neil3	Nei-like DNA glycosylase 3. (549 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (708 aa)
	LOC113574810	AP_endonuc_2 domain-containing protein. (328 aa)
	parp2	Poly [ADP-ribose] polymerase. (572 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (585 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1012 aa)
	pole4	CBFD_NFYB_HMF domain-containing protein. (127 aa)
	pole3	CBFD_NFYB_HMF domain-containing protein. (149 aa)
	polb	DNA_pol_B_thumb domain-containing protein. (54 aa)
	smug1	Uncharacterized protein. (290 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	LOC113590030	Uncharacterized protein. (347 aa)
	nthl1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (497 aa)
	LOC113583624	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
	pold2	Uncharacterized protein. (469 aa)
	LOC113586428	Thymine DNA glycosylase, tandem duplicate 2. (417 aa)
	LOC113586448	UDG domain-containing protein. (465 aa)
	Mbd4	Methyl-CpG binding domain protein 4. (167 aa)
	LOC113589274	Uncharacterized protein. (198 aa)
	apex2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (567 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (295 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113571395	LOC113590030	ENSEEEP00000000250	ENSEEEP00000033260	Polymerase (DNA directed), epsilon 2.	Uncharacterized protein.	0.763
LOC113571395	Pole	ENSEEEP00000000250	ENSEEEP00000017944	Polymerase (DNA directed), epsilon 2.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.989
LOC113571395	apex1	ENSEEEP00000000250	ENSEEEP00000002749	Polymerase (DNA directed), epsilon 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.631
LOC113571395	apex2	ENSEEEP00000000250	ENSEEEP00000048970	Polymerase (DNA directed), epsilon 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.513
LOC113571395	fen1	ENSEEEP00000000250	ENSEEEP00000032875	Polymerase (DNA directed), epsilon 2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.763
LOC113571395	lig3	ENSEEEP00000000250	ENSEEEP00000008580	Polymerase (DNA directed), epsilon 2.	DNA ligase.	0.574
LOC113571395	pcna	ENSEEEP00000000250	ENSEEEP00000028033	Polymerase (DNA directed), epsilon 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.760
LOC113571395	polb	ENSEEEP00000000250	ENSEEEP00000031853	Polymerase (DNA directed), epsilon 2.	DNA_pol_B_thumb domain-containing protein.	0.430
LOC113571395	pold1	ENSEEEP00000000250	ENSEEEP00000002302	Polymerase (DNA directed), epsilon 2.	DNA polymerase.	0.921
LOC113571395	pold2	ENSEEEP00000000250	ENSEEEP00000040348	Polymerase (DNA directed), epsilon 2.	Uncharacterized protein.	0.904
LOC113571395	pold3	ENSEEEP00000000250	ENSEEEP00000005809	Polymerase (DNA directed), epsilon 2.	Uncharacterized protein.	0.683
LOC113571395	pole3	ENSEEEP00000000250	ENSEEEP00000031747	Polymerase (DNA directed), epsilon 2.	CBFD_NFYB_HMF domain-containing protein.	0.996
LOC113571395	pole4	ENSEEEP00000000250	ENSEEEP00000030341	Polymerase (DNA directed), epsilon 2.	CBFD_NFYB_HMF domain-containing protein.	0.994
LOC113571395	poll	ENSEEEP00000000250	ENSEEEP00000027848	Polymerase (DNA directed), epsilon 2.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.434
LOC113574810	LOC113583624	ENSEEEP00000022763	ENSEEEP00000039520	AP_endonuc_2 domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.701
LOC113574810	LOC113586428	ENSEEEP00000022763	ENSEEEP00000043878	AP_endonuc_2 domain-containing protein.	Thymine DNA glycosylase, tandem duplicate 2.	0.414
LOC113574810	LOC113586448	ENSEEEP00000022763	ENSEEEP00000043882	AP_endonuc_2 domain-containing protein.	UDG domain-containing protein.	0.414
LOC113574810	LOC113590030	ENSEEEP00000022763	ENSEEEP00000033260	AP_endonuc_2 domain-containing protein.	Uncharacterized protein.	0.594
LOC113574810	Pole	ENSEEEP00000022763	ENSEEEP00000017944	AP_endonuc_2 domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.462
LOC113574810	apex1	ENSEEEP00000022763	ENSEEEP00000002749	AP_endonuc_2 domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.988