(19 nodes) Mismatch repair network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
	pold1	DNA polymerase. (1061 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	pold3	Uncharacterized protein. (462 aa)
	pold4	Uncharacterized protein. (109 aa)
	rfc2	AAA domain-containing protein. (369 aa)
	rfc1	Replication factor C subunit 1. (1124 aa)
	mlh1	DNA_mis_repair domain-containing protein. (724 aa)
	exo1	Exonuclease 1. (771 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (832 aa)
	rfc3	AAA domain-containing protein. (356 aa)
	rpa3	Uncharacterized protein. (122 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (939 aa)
	pold2	Uncharacterized protein. (469 aa)
	mlh3	Uncharacterized protein. (1098 aa)
	ssbp1	Uncharacterized protein. (149 aa)
	rpa2	RPA_C domain-containing protein. (280 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1371 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
exo1	mlh1	ENSEEEP00000019719	ENSEEEP00000016195	Exonuclease 1.	DNA_mis_repair domain-containing protein.	0.993
exo1	mlh3	ENSEEEP00000019719	ENSEEEP00000041330	Exonuclease 1.	Uncharacterized protein.	0.898
exo1	msh2	ENSEEEP00000019719	ENSEEEP00000035660	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.993
exo1	msh6	ENSEEEP00000019719	ENSEEEP00000046345	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.973
exo1	pcna	ENSEEEP00000019719	ENSEEEP00000028033	Exonuclease 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.964
exo1	pms2	ENSEEEP00000019719	ENSEEEP00000021207	Exonuclease 1.	PMS1 homolog 2, mismatch repair system component.	0.972
exo1	pold1	ENSEEEP00000019719	ENSEEEP00000002302	Exonuclease 1.	DNA polymerase.	0.929
exo1	pold2	ENSEEEP00000019719	ENSEEEP00000040348	Exonuclease 1.	Uncharacterized protein.	0.824
exo1	pold3	ENSEEEP00000019719	ENSEEEP00000005809	Exonuclease 1.	Uncharacterized protein.	0.751
exo1	pold4	ENSEEEP00000019719	ENSEEEP00000006797	Exonuclease 1.	Uncharacterized protein.	0.468
exo1	rfc1	ENSEEEP00000019719	ENSEEEP00000013629	Exonuclease 1.	Replication factor C subunit 1.	0.833
exo1	rfc2	ENSEEEP00000019719	ENSEEEP00000010158	Exonuclease 1.	AAA domain-containing protein.	0.837
exo1	rfc3	ENSEEEP00000019719	ENSEEEP00000022821	Exonuclease 1.	AAA domain-containing protein.	0.917
exo1	rfc4	ENSEEEP00000019719	ENSEEEP00000002918	Exonuclease 1.	AAA domain-containing protein.	0.904
exo1	rpa1	ENSEEEP00000019719	ENSEEEP00000001444	Exonuclease 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.901
exo1	rpa2	ENSEEEP00000019719	ENSEEEP00000044227	Exonuclease 1.	RPA_C domain-containing protein.	0.639
exo1	rpa3	ENSEEEP00000019719	ENSEEEP00000024425	Exonuclease 1.	Uncharacterized protein.	0.746
exo1	ssbp1	ENSEEEP00000019719	ENSEEEP00000043165	Exonuclease 1.	Uncharacterized protein.	0.606
mlh1	exo1	ENSEEEP00000016195	ENSEEEP00000019719	DNA_mis_repair domain-containing protein.	Exonuclease 1.	0.993
mlh1	mlh3	ENSEEEP00000016195	ENSEEEP00000041330	DNA_mis_repair domain-containing protein.	Uncharacterized protein.	0.997