STRINGSTRING
rpa1 rpa1 brip1 brip1 pold1 pold1 LOC113568250 LOC113568250 pold3 pold3 pold4 pold4 rad51d rad51d nbn nbn top3a top3a babam2 babam2 rad54l rad54l rad50 rad50 xrcc3 xrcc3 rad51 rad51 rpa3 rpa3 babam1 babam1 ENSEEEP00000032310 ENSEEEP00000032310 rbbp8 rbbp8 XRCC2 XRCC2 pold2 pold2 mus81 mus81 rad54b rad54b ssbp1 ssbp1 brcc3 brcc3 uimc1 uimc1 rpa2 rpa2 sycp3 sycp3 rad52 rad52 sem1 sem1 eme1 eme1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
brip1Helicase ATP-binding domain-containing protein. (1220 aa)
pold1DNA polymerase. (1061 aa)
LOC113568250RAD51 paralog C. (260 aa)
pold3Uncharacterized protein. (462 aa)
pold4Uncharacterized protein. (109 aa)
rad51dRECA_2 domain-containing protein. (338 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (816 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1009 aa)
babam2Uncharacterized protein. (442 aa)
rad54lRAD54 like. (741 aa)
rad50RAD50 homolog, double strand break repair protein. (1181 aa)
xrcc3RECA_2 domain-containing protein. (355 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
rpa3Uncharacterized protein. (122 aa)
babam1Uncharacterized protein. (359 aa)
ENSEEEP00000032310ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3024 aa)
rbbp8SAE2 domain-containing protein. (131 aa)
XRCC2RECA_2 domain-containing protein. (302 aa)
pold2Uncharacterized protein. (469 aa)
mus81MUS81 structure-specific endonuclease subunit. (615 aa)
rad54bRAD54 homolog B. (847 aa)
ssbp1Uncharacterized protein. (149 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (269 aa)
uimc1RAP80_UIM domain-containing protein. (953 aa)
rpa2RPA_C domain-containing protein. (280 aa)
sycp3Synaptonemal complex protein 3. (235 aa)
rad52RAD52 homolog, DNA repair protein. (287 aa)
sem1Uncharacterized protein. (70 aa)
eme1Essential meiotic structure-specific endonuclease 1. (550 aa)
Your Current Organism:
Electrophorus electricus
NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish
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