(78 nodes) ErbB signaling pathway network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pak4	Non-specific serine/threonine protein kinase. (659 aa)
	LOC113589852	Uncharacterized protein. (187 aa)
	ENSEEEP00000000723	NCK adaptor protein 2a. (193 aa)
	LOC113572522	Uncharacterized protein. (194 aa)
	LOC113572036	Tyrosine-protein kinase. (584 aa)
	LOC113578033	Mitogen-activated protein kinase. (447 aa)
	LOC113581493	EGF-like domain-containing protein. (225 aa)
	LOC113586001	Uncharacterized protein. (209 aa)
	ENSEEEP00000004531	Protein kinase C, beta b. (195 aa)
	LOC113587165	Uncharacterized protein. (330 aa)
	ENSEEEP00000005099	Amphiregulin. (219 aa)
	Shc2	SHC (Src homology 2 domain containing) transforming protein 2. (407 aa)
	LOC113574265	Mitogen-activated protein kinase. (446 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (533 aa)
	CRK	Uncharacterized protein. (311 aa)
	LOC113583945	Tyrosine-protein kinase. (1088 aa)
	LOC113577720	Son of sevenless homolog 2 (Drosophila). (1331 aa)
	LOC113568414	Uncharacterized protein; Belongs to the protein kinase superfamily. (459 aa)
	LOC113570943	Protein kinase domain-containing protein. (515 aa)
	LOC113573843	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (401 aa)
	akt3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (493 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1082 aa)
	LOC113580611	Raf-1 proto-oncogene, serine/threonine kinase b. (656 aa)
	LOC113567981	Uncharacterized protein. (464 aa)
	nrg1	Neuregulin 1. (746 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (386 aa)
	cblb	Cbl proto-oncogene B, E3 ubiquitin protein ligase. (841 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (896 aa)
	LOC113572287	Uncharacterized protein. (657 aa)
	pik3r1	Uncharacterized protein. (728 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1263 aa)
	LOC113589839	Non-specific serine/threonine protein kinase. (736 aa)
	plcg1	Phosphoinositide phospholipase C. (1327 aa)
	LOC113588939	Mitogen-activated protein kinase kinase 2a. (569 aa)
	ENSEEEP00000029525	Neuregulin 2b. (269 aa)
	LOC113570753	EGF-like domain-containing protein. (179 aa)
	crkl	Uncharacterized protein. (305 aa)
	cdkn1a	Uncharacterized protein. (166 aa)
	LOC113572439	Tyrosine-protein kinase. (537 aa)
	mapk10	Mitogen-activated protein kinase. (244 aa)
	MAPK10	Mitogen-activated protein kinase 10. (232 aa)
	LOC113584672	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	LOC113579639	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
	LOC113580901	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (754 aa)
	LOC113589106	BZIP domain-containing protein; Belongs to the bZIP family. (324 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (801 aa)
	LOC113583571	Uncharacterized protein. (191 aa)
	LOC113581977	Signal transducer and activator of transcription. (788 aa)
	LOC113568160	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (465 aa)
	erbb4	Receptor protein-tyrosine kinase. (1408 aa)
	ENSEEEP00000038897	NCK adaptor protein 1b. (200 aa)
	LOC113574073	Cytoplasmic protein. (383 aa)
	LOC113571260	Mitogen-activated protein kinase. (426 aa)
	LOC113577873	BHLH domain-containing protein. (360 aa)
	LOC113579694	Uncharacterized protein. (189 aa)
	LOC113591405	Mitogen-activated protein kinase kinase 4a; Belongs to the protein kinase superfamily. (412 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (453 aa)
	LOC113575233	Growth factor receptor-bound protein 2b. (203 aa)
	araf	A-Raf proto-oncogene, serine/threonine kinase. (608 aa)
	LOC113584789	Uncharacterized protein. (217 aa)
	LOC113573558	Uncharacterized protein. (174 aa)
	nras	Uncharacterized protein. (188 aa)
	LOC113585265	Heparin-binding EGF-like growth factor b. (138 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2557 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	LOC113588524	Uncharacterized protein. (189 aa)
	LOC113582834	BZIP domain-containing protein. (352 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	erbb2	Receptor protein-tyrosine kinase. (1224 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1049 aa)
	LOC113589820	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (377 aa)
	hras	Uncharacterized protein. (189 aa)
	LOC113579817	Uncharacterized protein. (205 aa)
	LOC113576303	Tyrosine-protein kinase. (561 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LOC113581376	Erb-b2 receptor tyrosine kinase 3b. (1440 aa)
	LOC113576367	Non-specific serine/threonine protein kinase. (522 aa)
	LOC113569771	Uncharacterized protein. (309 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRK	LOC113569771	ENSEEEP00000007678	ENSEEEP00000052612	Uncharacterized protein.	Uncharacterized protein.	0.901
CRK	LOC113570943	ENSEEEP00000007678	ENSEEEP00000014973	Uncharacterized protein.	Protein kinase domain-containing protein.	0.911
CRK	LOC113571260	ENSEEEP00000007678	ENSEEEP00000040040	Uncharacterized protein.	Mitogen-activated protein kinase.	0.919
CRK	LOC113572036	ENSEEEP00000007678	ENSEEEP00000003266	Uncharacterized protein.	Tyrosine-protein kinase.	0.965
CRK	LOC113572439	ENSEEEP00000007678	ENSEEEP00000032703	Uncharacterized protein.	Tyrosine-protein kinase.	0.501
CRK	LOC113574265	ENSEEEP00000007678	ENSEEEP00000006399	Uncharacterized protein.	Mitogen-activated protein kinase.	0.921
CRK	LOC113575233	ENSEEEP00000007678	ENSEEEP00000041421	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.721
CRK	LOC113576303	ENSEEEP00000007678	ENSEEEP00000050391	Uncharacterized protein.	Tyrosine-protein kinase.	0.501
CRK	LOC113577720	ENSEEEP00000007678	ENSEEEP00000014017	Uncharacterized protein.	Son of sevenless homolog 2 (Drosophila).	0.643
CRK	LOC113578033	ENSEEEP00000007678	ENSEEEP00000003480	Uncharacterized protein.	Mitogen-activated protein kinase.	0.921
CRK	LOC113583945	ENSEEEP00000007678	ENSEEEP00000010702	Uncharacterized protein.	Tyrosine-protein kinase.	0.965
CRK	LOC113584789	ENSEEEP00000007678	ENSEEEP00000043867	Uncharacterized protein.	Uncharacterized protein.	0.721
CRK	LOC113591405	ENSEEEP00000007678	ENSEEEP00000040920	Uncharacterized protein.	Mitogen-activated protein kinase kinase 4a; Belongs to the protein kinase superfamily.	0.911
CRK	MAPK10	ENSEEEP00000007678	ENSEEEP00000034774	Uncharacterized protein.	Mitogen-activated protein kinase 10.	0.921
CRK	Shc2	ENSEEEP00000007678	ENSEEEP00000005458	Uncharacterized protein.	SHC (Src homology 2 domain containing) transforming protein 2.	0.561
CRK	cbl	ENSEEEP00000007678	ENSEEEP00000019709	Uncharacterized protein.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.782
CRK	cblb	ENSEEEP00000007678	ENSEEEP00000018798	Uncharacterized protein.	Cbl proto-oncogene B, E3 ubiquitin protein ligase.	0.782
CRK	crkl	ENSEEEP00000007678	ENSEEEP00000030538	Uncharacterized protein.	Uncharacterized protein.	0.911
CRK	erbb2	ENSEEEP00000007678	ENSEEEP00000048444	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.400
CRK	mapk10	ENSEEEP00000007678	ENSEEEP00000034640	Uncharacterized protein.	Mitogen-activated protein kinase.	0.921