(61 nodes) VEGF signaling pathway network (Electrophorus electricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hspb1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (211 aa)
	LOC113589852	Uncharacterized protein. (187 aa)
	LOC113572585	Uncharacterized protein. (191 aa)
	LOC113575357	Mitogen-activated protein kinase. (351 aa)
	LOC113575356	Mitogen-activated protein kinase. (364 aa)
	LOC113586001	Uncharacterized protein. (209 aa)
	ENSEEEP00000004531	Protein kinase C, beta b. (195 aa)
	LOC113587165	Uncharacterized protein. (330 aa)
	Shc2	SHC (Src homology 2 domain containing) transforming protein 2. (407 aa)
	LOC113574264	Uncharacterized protein. (192 aa)
	ENSEEEP00000011760	Paxillin b. (260 aa)
	LOC113575458	Uncharacterized protein. (191 aa)
	LOC113568414	Uncharacterized protein; Belongs to the protein kinase superfamily. (459 aa)
	LOC113571665	RHD domain-containing protein. (874 aa)
	LOC113590096	Mitogen-activated protein kinase. (389 aa)
	akt3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (493 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1082 aa)
	LOC113572343	Serine/threonine-protein phosphatase. (511 aa)
	LOC113580611	Raf-1 proto-oncogene, serine/threonine kinase b. (656 aa)
	LOC113567981	Uncharacterized protein. (464 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (386 aa)
	LOC113572287	Uncharacterized protein. (657 aa)
	pik3r1	Uncharacterized protein. (728 aa)
	LOC113578974	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (189 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1263 aa)
	LOC113580757	DAGKc domain-containing protein. (375 aa)
	LOC113585124	EGF-like domain-containing protein. (616 aa)
	plcg1	Phosphoinositide phospholipase C. (1327 aa)
	LOC113585128	Phospholipase A2. (740 aa)
	LOC113588939	Mitogen-activated protein kinase kinase 2a. (569 aa)
	LOC113581750	Serine/threonine-protein phosphatase. (508 aa)
	ENSEEEP00000030422	Serine/threonine-protein phosphatase. (291 aa)
	LOC113584625	Uncharacterized protein. (205 aa)
	LOC113572439	Tyrosine-protein kinase. (537 aa)
	LOC113584672	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	mapkapk3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	LOC113579658	Uncharacterized protein. (186 aa)
	LOC113579639	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
	LOC113580901	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (754 aa)
	sh2d2a	SH2 domain-containing protein. (549 aa)
	mapkapk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	LOC113583627	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (194 aa)
	LOC113579694	Uncharacterized protein. (189 aa)
	LOC113588667	EGF-like domain-containing protein. (630 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1321 aa)
	LOC113588638	Phospholipase A2. (757 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (510 aa)
	LOC113572862	Uncharacterized protein. (192 aa)
	nras	Uncharacterized protein. (188 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	LOC113588524	Uncharacterized protein. (189 aa)
	LOC113577382	Mitogen-activated protein kinase. (365 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1049 aa)
	hras	Uncharacterized protein. (189 aa)
	LOC113579817	Uncharacterized protein. (205 aa)
	LOC113576303	Tyrosine-protein kinase. (561 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (849 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	ENSEEEP00000051140	Sphingosine kinase 2. (571 aa)
	LOC113576377	Mitogen-activated protein kinase. (359 aa)

Your Current Organism:

Electrophorus electricus

NCBI taxonomy Id: 8005
Other names: E. electricus, electric eel, electric knifefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEEP00000004531	ENSEEEP00000051140	ENSEEEP00000004531	ENSEEEP00000051140	Protein kinase C, beta b.	Sphingosine kinase 2.	0.932
ENSEEEP00000004531	LOC113572287	ENSEEEP00000004531	ENSEEEP00000019866	Protein kinase C, beta b.	Uncharacterized protein.	0.908
ENSEEEP00000004531	LOC113579639	ENSEEEP00000004531	ENSEEEP00000035856	Protein kinase C, beta b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
ENSEEEP00000004531	LOC113579694	ENSEEEP00000004531	ENSEEEP00000040602	Protein kinase C, beta b.	Uncharacterized protein.	0.919
ENSEEEP00000004531	LOC113580611	ENSEEEP00000004531	ENSEEEP00000016878	Protein kinase C, beta b.	Raf-1 proto-oncogene, serine/threonine kinase b.	0.908
ENSEEEP00000004531	LOC113580757	ENSEEEP00000004531	ENSEEEP00000023183	Protein kinase C, beta b.	DAGKc domain-containing protein.	0.932
ENSEEEP00000004531	LOC113580901	ENSEEEP00000004531	ENSEEEP00000036427	Protein kinase C, beta b.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
ENSEEEP00000004531	LOC113588524	ENSEEEP00000004531	ENSEEEP00000046373	Protein kinase C, beta b.	Uncharacterized protein.	0.919
ENSEEEP00000004531	LOC113589852	ENSEEEP00000004531	ENSEEEP00000000572	Protein kinase C, beta b.	Uncharacterized protein.	0.919
ENSEEEP00000004531	hras	ENSEEEP00000004531	ENSEEEP00000049180	Protein kinase C, beta b.	Uncharacterized protein.	0.919
ENSEEEP00000004531	nras	ENSEEEP00000004531	ENSEEEP00000044709	Protein kinase C, beta b.	Uncharacterized protein.	0.919
ENSEEEP00000004531	plcg1	ENSEEEP00000004531	ENSEEEP00000027019	Protein kinase C, beta b.	Phosphoinositide phospholipase C.	0.910
ENSEEEP00000004531	plcg2	ENSEEEP00000004531	ENSEEEP00000022431	Protein kinase C, beta b.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.910
ENSEEEP00000011760	LOC113572439	ENSEEEP00000011760	ENSEEEP00000032703	Paxillin b.	Tyrosine-protein kinase.	0.683
ENSEEEP00000011760	LOC113572585	ENSEEEP00000011760	ENSEEEP00000002218	Paxillin b.	Uncharacterized protein.	0.454
ENSEEEP00000011760	LOC113572862	ENSEEEP00000011760	ENSEEEP00000042255	Paxillin b.	Uncharacterized protein.	0.492
ENSEEEP00000011760	LOC113574264	ENSEEEP00000011760	ENSEEEP00000007195	Paxillin b.	Uncharacterized protein.	0.492
ENSEEEP00000011760	LOC113575458	ENSEEEP00000011760	ENSEEEP00000014086	Paxillin b.	Uncharacterized protein.	0.482
ENSEEEP00000011760	LOC113576303	ENSEEEP00000011760	ENSEEEP00000050391	Paxillin b.	Tyrosine-protein kinase.	0.683
ENSEEEP00000011760	LOC113584625	ENSEEEP00000011760	ENSEEEP00000032046	Paxillin b.	Uncharacterized protein.	0.492