STRINGSTRING
tp53bp1 tp53bp1 chek2 chek2 rad51 rad51 xrcc3 xrcc3 ENSELUP00000005976 ENSELUP00000005976 brca1 brca1 atr atr brca2 brca2 LOC105013139 LOC105013139 LOC105016143 LOC105016143 rad51b rad51b mre11 mre11 nbn nbn rad51c rad51c exo1 exo1 XRCC2 XRCC2 DNA2 DNA2 atm atm rad51d rad51d recql4 recql4 rad52 rad52 LOC105028498 LOC105028498 ENSELUP00000037811 ENSELUP00000037811 wrn wrn dmc1 dmc1 fen1 fen1 LOC105031589 LOC105031589 LOC105011230 LOC105011230
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53bp1Tumor protein p53 binding protein, 1. (1856 aa)
chek2Checkpoint kinase 2. (513 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
ENSELUP00000005976BRCA1 interacting protein C-terminal helicase 1. (941 aa)
brca1Uncharacterized protein. (1565 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa)
brca2BRCA2 DNA repair associated. (2826 aa)
LOC105013139ATPase family AAA domain containing 5a. (1854 aa)
LOC105016143BRCA1 associated RING domain 1. (809 aa)
rad51bRAD51 paralog B. (378 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa)
rad51cRAD51 paralog C. (359 aa)
exo1Exonuclease 1. (801 aa)
XRCC2X-ray repair cross complementing 2. (316 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
atmNon-specific serine/threonine protein kinase. (3011 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa)
recql4RecQ helicase-like 4. (1558 aa)
rad52RAD52 homolog, DNA repair protein. (440 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
ENSELUP00000037811BRCT domain-containing protein. (139 aa)
wrnWRN RecQ like helicase. (1484 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC105031589Retinoblastoma binding protein 8. (690 aa)
LOC105011230RAD50 homolog, double strand break repair protein. (1314 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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