STRINGSTRING
slx4 slx4 ENSELUP00000002257 ENSELUP00000002257 rtel1 rtel1 rad51 rad51 stn1 stn1 zbtb48 zbtb48 pot1 pot1 pinx1 pinx1 ino80e ino80e xrcc3 xrcc3 Rif1 Rif1 ENSELUP00000006082 ENSELUP00000006082 atr atr brca2 brca2 LOC105025379 LOC105025379 telo2 telo2 tprkb tprkb ccne2 ccne2 LOC105020774 LOC105020774 mre11 mre11 nbn nbn dclre1c dclre1c LOC105016238 LOC105016238 rad51c rad51c tfpt tfpt ptges3 ptges3 tert tert ENSELUP00000016298 ENSELUP00000016298 hus1 hus1 xrcc1 xrcc1 atm atm LOC105015403 LOC105015403 blm blm ercc4 ercc4 rad51d rad51d pif1 pif1 ENSELUP00000021469 ENSELUP00000021469 mcrs1 mcrs1 rpa1 rpa1 nhp2 nhp2 recql4 recql4 ino80d ino80d wrap53 wrap53 fbxo4 fbxo4 nsmce2 nsmce2 uchl5 uchl5 tinf2 tinf2 LOC105028498 LOC105028498 nop10 nop10 ENSELUP00000032389 ENSELUP00000032389 LOC105023832 LOC105023832 smc5 smc5 ENSELUP00000035354 ENSELUP00000035354 znf827 znf827 dkc1 dkc1 ercc1 ercc1 prkdc prkdc wrn wrn parp3 parp3 smc6 smc6 nfrkb nfrkb xrcc6 xrcc6 gar1 gar1 lto1 lto1 LOC105011230 LOC105011230 dclre1a dclre1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1998 aa)
ENSELUP00000002257Uncharacterized protein. (1610 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1198 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (381 aa)
zbtb48Zinc finger and BTB domain containing 48. (787 aa)
pot1Protection of telomeres 1 homolog. (802 aa)
pinx1PIN2 (TERF1) interacting telomerase inhibitor 1. (387 aa)
ino80eINO80 complex subunit E. (225 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
Rif1Replication timing regulatory factor 1. (2843 aa)
ENSELUP00000006082Uncharacterized protein. (1306 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa)
brca2BRCA2 DNA repair associated. (2826 aa)
LOC105025379Zgc:101664. (201 aa)
telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae). (834 aa)
tprkbUncharacterized protein; Belongs to the CGI121/TPRKB family. (178 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (398 aa)
LOC105020774Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (266 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (696 aa)
LOC105016238Uncharacterized protein. (610 aa)
rad51cRAD51 paralog C. (359 aa)
tfptUncharacterized protein. (206 aa)
ptges3Prostaglandin E synthase 3b (cytosolic). (241 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1129 aa)
ENSELUP00000016298Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (283 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (629 aa)
atmNon-specific serine/threonine protein kinase. (3011 aa)
LOC105015403Structural maintenance of chromosomes 6. (1082 aa)
blmBLM RecQ like helicase. (1473 aa)
ercc4Excision repair cross-complementation group 4. (892 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (682 aa)
ENSELUP00000021469INO80 complex ATPase subunit. (1485 aa)
mcrs1Microspherule protein 1. (476 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
nhp2NHP2 ribonucleoprotein homolog (yeast). (117 aa)
recql4RecQ helicase-like 4. (1558 aa)
ino80dINO80 complex subunit Da. (992 aa)
wrap53WD repeat containing, antisense to TP53. (554 aa)
fbxo4F-box protein 4. (382 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (226 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
tinf2TERF1 (TRF1)-interacting nuclear factor 2. (590 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
nop10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ENSELUP00000032389Uncharacterized protein. (476 aa)
LOC105023832Prostaglandin E synthase 3a (cytosolic). (173 aa)
smc5AAA_23 domain-containing protein. (1081 aa)
ENSELUP00000035354DNA cross-link repair 1B. (598 aa)
znf827Zinc finger protein 827. (1235 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (507 aa)
ercc1Excision repair cross-complementation group 1. (364 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4077 aa)
wrnWRN RecQ like helicase. (1484 aa)
parp3Poly [ADP-ribose] polymerase. (553 aa)
smc6Si:dkey-119f1.1. (1078 aa)
nfrkbNuclear factor related to kappaB binding protein. (1278 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (221 aa)
lto1Oral cancer overexpressed protein 1. (141 aa)
LOC105011230RAD50 homolog, double strand break repair protein. (1314 aa)
dclre1aDNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (950 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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