(49 nodes) Neural tube closure network (Esox lucius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105012314	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1100 aa)
	sfrp2	Secreted frizzled-related protein 2. (292 aa)
	phactr4	Phosphatase and actin regulator. (902 aa)
	sall4	Spalt-like transcription factor 4. (1128 aa)
	dvl3	Dishevelled segment polarity protein 3b. (716 aa)
	cobl	Cordon-bleu WH2 repeat protein. (1331 aa)
	LOC105010801	Dishevelled segment polarity protein 2. (853 aa)
	LOC105027820	TSC complex subunit 1a. (1217 aa)
	LOC105024057	Uncharacterized protein. (324 aa)
	mks1	MKS transition zone complex subunit 1. (560 aa)
	cthrc1	Collagen triple helix repeat containing 1a. (236 aa)
	CCDC85B	Coiled-coil domain containing 85B. (186 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	ENSELUP00000016945	TSC complex subunit 2. (1225 aa)
	PHACTR1	Phosphatase and actin regulator. (644 aa)
	LOC105023960	Glomulin, FKBP associated protein a. (631 aa)
	ENSELUP00000019775	DEP domain-containing protein. (314 aa)
	ENSELUP00000020425	Lysine (K)-specific demethylase 6A. (1436 aa)
	LOC105010856	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	ENSELUP00000021127	Uncharacterized protein. (294 aa)
	LOC105019307	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	LOC105027026	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	BBS4	Bardet-Biedl syndrome 4. (546 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2795 aa)
	fuz	Fuzzy planar cell polarity protein. (449 aa)
	LOC105018671	Bardet-Biedl syndrome 4. (530 aa)
	bcl10	BCL10 immune signaling adaptor. (267 aa)
	phactr1	Phosphatase and actin regulator. (613 aa)
	tmed2	Transmembrane emp24 domain-containing protein 2. (201 aa)
	CCDC85B-2	Coiled-coil domain containing 85B. (194 aa)
	hectd1	HECT domain containing 1. (2616 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (954 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (559 aa)
	deaf1	DEAF1 transcription factor. (557 aa)
	abl2	Tyrosine-protein kinase. (1182 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1080 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (671 aa)
	ENSELUP00000032947	Uncharacterized protein. (821 aa)
	Abl1	Tyrosine-protein kinase. (1101 aa)
	prkaca	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
	LOC105021712	Uncharacterized protein. (824 aa)
	tsc1	TSC complex subunit 1b. (1256 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (1075 aa)
	LOC105021702	Serine peptidase inhibitor, Kunitz type 1 b. (541 aa)
	LOC105018167	CECR2 histone acetyl-lysine reader. (1194 aa)
	LOC105020639	Uncharacterized protein. (771 aa)
	dvl1	Dishevelled segment polarity protein 1a. (859 aa)
	ENSELUP00000040861	Dishevelled segment polarity protein 3a. (661 aa)
	LOC105013090	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (379 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abl1	abl2	ENSELUP00000034880	ENSELUP00000031113	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.913
BBS4	LOC105027820	ENSELUP00000023164	ENSELUP00000008951	Bardet-Biedl syndrome 4.	TSC complex subunit 1a.	0.406
BBS4	tsc1	ENSELUP00000023164	ENSELUP00000037347	Bardet-Biedl syndrome 4.	TSC complex subunit 1b.	0.406
ENSELUP00000016945	LOC105027820	ENSELUP00000016945	ENSELUP00000008951	TSC complex subunit 2.	TSC complex subunit 1a.	0.980
ENSELUP00000016945	tsc1	ENSELUP00000016945	ENSELUP00000037347	TSC complex subunit 2.	TSC complex subunit 1b.	0.980
ENSELUP00000019775	LOC105024057	ENSELUP00000019775	ENSELUP00000010672	DEP domain-containing protein.	Uncharacterized protein.	0.444
ENSELUP00000019775	sfrp2	ENSELUP00000019775	ENSELUP00000002664	DEP domain-containing protein.	Secreted frizzled-related protein 2.	0.444
ENSELUP00000020425	LOC105027820	ENSELUP00000020425	ENSELUP00000008951	Lysine (K)-specific demethylase 6A.	TSC complex subunit 1a.	0.736
ENSELUP00000020425	setd2	ENSELUP00000020425	ENSELUP00000025183	Lysine (K)-specific demethylase 6A.	SET domain containing 2, histone lysine methyltransferase.	0.764
ENSELUP00000020425	tsc1	ENSELUP00000020425	ENSELUP00000037347	Lysine (K)-specific demethylase 6A.	TSC complex subunit 1b.	0.736
ENSELUP00000040861	LOC105024057	ENSELUP00000040861	ENSELUP00000010672	Dishevelled segment polarity protein 3a.	Uncharacterized protein.	0.444
ENSELUP00000040861	sfrp2	ENSELUP00000040861	ENSELUP00000002664	Dishevelled segment polarity protein 3a.	Secreted frizzled-related protein 2.	0.444
LOC105010801	LOC105024057	ENSELUP00000006826	ENSELUP00000010672	Dishevelled segment polarity protein 2.	Uncharacterized protein.	0.444
LOC105010801	sfrp2	ENSELUP00000006826	ENSELUP00000002664	Dishevelled segment polarity protein 2.	Secreted frizzled-related protein 2.	0.444
LOC105010856	LOC105027026	ENSELUP00000021118	ENSELUP00000022296	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.902
LOC105012314	cobl	ENSELUP00000016616	ENSELUP00000006145	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cordon-bleu WH2 repeat protein.	0.433
LOC105018167	setd2	ENSELUP00000038390	ENSELUP00000025183	CECR2 histone acetyl-lysine reader.	SET domain containing 2, histone lysine methyltransferase.	0.543
LOC105018671	LOC105027820	ENSELUP00000025650	ENSELUP00000008951	Bardet-Biedl syndrome 4.	TSC complex subunit 1a.	0.406
LOC105018671	tsc1	ENSELUP00000025650	ENSELUP00000037347	Bardet-Biedl syndrome 4.	TSC complex subunit 1b.	0.406
LOC105020639	LOC105024057	ENSELUP00000038988	ENSELUP00000010672	Uncharacterized protein.	Uncharacterized protein.	0.444