STRINGSTRING
TEX264 TEX264 tp53bp1 tp53bp1 ENSELUP00000001840 ENSELUP00000001840 pold2 pold2 rfc5 rfc5 rpa3 rpa3 timeless timeless LOC105017168 LOC105017168 wrn wrn prim1 prim1 dmap1 dmap1 ENSELUP00000035242 ENSELUP00000035242 uhrf1 uhrf1 ENSELUP00000031341 ENSELUP00000031341 polh polh rfc3 rfc3 ENSELUP00000030130 ENSELUP00000030130 ENSELUP00000029732 ENSELUP00000029732 hmces hmces LOC105028498 LOC105028498 pola2 pola2 primpol primpol LOC105029954 LOC105029954 DONSON DONSON ENSELUP00000026557 ENSELUP00000026557 dnmt1 dnmt1 mms22l mms22l ENSELUP00000022232 ENSELUP00000022232 rpa1 rpa1 prim2 prim2 pold4 pold4 prpf19 prpf19 Tipin Tipin pif1 pif1 rad51d rad51d pold3 pold3 rad18 rad18 XRCC2 XRCC2 wdhd1 wdhd1 zranb3 zranb3 rfc2 rfc2 ENSELUP00000014017 ENSELUP00000014017 pold1 pold1 helb helb rad51c rad51c radx radx mre11 mre11 smarcal1 smarcal1 rfc4 rfc4 rad51b rad51b xrcc3 xrcc3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEX264Testis expressed 264, ER-phagy receptor. (305 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1856 aa)
ENSELUP00000001840Checkpoint kinase 1. (382 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
rfc5AAA domain-containing protein. (335 aa)
rpa3Uncharacterized protein. (121 aa)
timelessTimeless circadian clock. (1235 aa)
LOC105017168Testis expressed 264, ER-phagy receptor a. (351 aa)
wrnWRN RecQ like helicase. (1484 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
dmap1DNA methyltransferase 1 associated protein 1. (487 aa)
ENSELUP00000035242Mcm10 domain-containing protein. (660 aa)
uhrf1Ubiquitin-like with PHD and ring finger domains 1. (786 aa)
ENSELUP00000031341DNA polymerase. (1412 aa)
polhPolymerase (DNA directed), eta. (779 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
ENSELUP00000029732Minichromosome maintenance 10 replication initiation factor. (781 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (375 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (608 aa)
primpolPrimase and polymerase (DNA-directed). (592 aa)
LOC105029954Pre-mRNA processing factor 19. (475 aa)
DONSONDownstream neighbor of SON. (603 aa)
ENSELUP00000026557Zf-primase domain-containing protein. (173 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1530 aa)
mms22lMMS22-like, DNA repair protein. (1239 aa)
ENSELUP00000022232Uncharacterized protein. (589 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (520 aa)
pold4Si:dkey-28b4.7. (109 aa)
prpf19Uncharacterized protein. (504 aa)
TipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (327 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (682 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
rad18RAD18 E3 ubiquitin protein ligase. (514 aa)
XRCC2X-ray repair cross complementing 2. (316 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (1263 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1168 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
ENSELUP00000014017Tonsoku-like, DNA repair protein. (1323 aa)
pold1DNA polymerase. (1105 aa)
helbHelicase (DNA) B. (1242 aa)
rad51cRAD51 paralog C. (359 aa)
radxRPA1 related single stranded DNA binding protein. (871 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
smarcal1Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (1041 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
rad51bRAD51 paralog B. (378 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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