STRINGSTRING
sfrp2 sfrp2 glg1 glg1 tgfb3 tgfb3 hivep1 hivep1 bmp4 bmp4 LOC105027830 LOC105027830 LOC105017704 LOC105017704 smad9 smad9 smad7 smad7 cldn5 cldn5 appl2 appl2 INHBC INHBC msx1 msx1 LOC105015086 LOC105015086 tgfb2 tgfb2 LOC105016079 LOC105016079 ENSELUP00000034469 ENSELUP00000034469 skil skil bmp3 bmp3 hpgd hpgd LOC105028221 LOC105028221 LOC105012052 LOC105012052 gdf5 gdf5 TMEM100 TMEM100 bmpr1a bmpr1a acvr2b acvr2b cdh5 cdh5 LOC105011541 LOC105011541 LOC105028753 LOC105028753 gdf11 gdf11 LOC105013596 LOC105013596 sirt1 sirt1 LOC105021125 LOC105021125 LOC105009048 LOC105009048 tgfbr3 tgfbr3 itgb8 itgb8 ENSELUP00000001341 ENSELUP00000001341 nrros nrros Magi2 Magi2 bmp15 bmp15 ccdc142 ccdc142 smad2 smad2 bmp2 bmp2 mstn mstn nodal nodal LOC105027013 LOC105027013 ENSELUP00000014068 ENSELUP00000014068 ENSELUP00000014330 ENSELUP00000014330 SMAD1-2 SMAD1-2 LOC105022886 LOC105022886 LOC105020506 LOC105020506 gdf3 gdf3 LOC105011631 LOC105011631 LOC105024259 LOC105024259 inha inha LOC105020592 LOC105020592 LOC105025159 LOC105025159 LOC105019986 LOC105019986 tgfb1i1 tgfb1i1 LOC105019479 LOC105019479 LOC105014199 LOC105014199 yap1 yap1 pxn pxn ppm1l ppm1l SMAD3 SMAD3 LOC105008258 LOC105008258 LOC105014505 LOC105014505 smad6 smad6 FAM83G FAM83G LOC105022549 LOC105022549 ENSELUP00000036872 ENSELUP00000036872 ENSELUP00000037263 ENSELUP00000037263 fkbp8 fkbp8 amh amh sostdc1 sostdc1 flcn flcn ENSELUP00000015901 ENSELUP00000015901 LOC105017213 LOC105017213 nlk nlk LOC105022528 LOC105022528 LOC105030895 LOC105030895 lef1 lef1 npnt npnt ENSELUP00000017609 ENSELUP00000017609 INHBB INHBB ENSELUP00000018634 ENSELUP00000018634 ACVR1C ACVR1C ACVR1 ACVR1 LOC105025942 LOC105025942 itgb6 itgb6 LOC105026156 LOC105026156 LOC105011191 LOC105011191 LOC105028705 LOC105028705 appl1 appl1 SMAD4 SMAD4 LOC105010856 LOC105010856 bmp5 bmp5 LOC105024537 LOC105024537 bmp6 bmp6 LOC105030804 LOC105030804 bmpr1b bmpr1b tab1 tab1 ENSELUP00000021915 ENSELUP00000021915 LOC105013587 LOC105013587 LOC105027026 LOC105027026 smad5 smad5 LOC105020594 LOC105020594 LOC105020595 LOC105020595 ENSELUP00000023671 ENSELUP00000023671 pdcd4 pdcd4 LOC105028827 LOC105028827 LOC105025164 LOC105025164 LOC105025165 LOC105025165 LOC105012389 LOC105012389 LOC105026064 LOC105026064 LOC105021940 LOC105021940 LOC105029333 LOC105029333 LOC105010781 LOC105010781 LOC105009031 LOC105009031 magi2 magi2 LOC105020079 LOC105020079 bambi bambi LOC105014363 LOC105014363 gdf10 gdf10 LOC109615754 LOC109615754 smpd3 smpd3 LOC105030836 LOC105030836 rgmb rgmb LOC105024057 LOC105024057 ENSELUP00000010618 ENSELUP00000010618 LOC105027755 LOC105027755 ENSELUP00000010474 ENSELUP00000010474 AMHR2 AMHR2 gdf6 gdf6 LOC105028100 LOC105028100 ENSELUP00000010012 ENSELUP00000010012 LOC105027242 LOC105027242 bmper bmper LOC105013159 LOC105013159 ENSELUP00000008164 ENSELUP00000008164 ACVR1B ACVR1B slc33a1 slc33a1 LOC105026733 LOC105026733 LOC105031060 LOC105031060 gdf7 gdf7 inhbb inhbb hjv hjv LOC105021636 LOC105021636 LOC105011734 LOC105011734 SMAD1 SMAD1 tbx2 tbx2 TGFBR2 TGFBR2 LOC105030502 LOC105030502 LOC105006568 LOC105006568 LOC105017334 LOC105017334 LOC105025163 LOC105025163 id1 id1 ENSELUP00000003897 ENSELUP00000003897 TGFB3 TGFB3 LOC105019845 LOC105019845 LOC105028288 LOC105028288 LOC105026675 LOC105026675 LOC105016248 LOC105016248
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sfrp2Secreted frizzled-related protein 2. (292 aa)
glg1Golgi glycoprotein 1a. (1141 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
hivep1Human immunodeficiency virus type I enhancer binding protein 1. (2797 aa)
bmp4Bone morphogenetic protein 4. (443 aa)
LOC105027830BTB (POZ) domain containing 11a. (1023 aa)
LOC105017704Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (585 aa)
smad9Mothers against decapentaplegic homolog. (466 aa)
smad7Mothers against decapentaplegic homolog. (377 aa)
cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
appl2Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (665 aa)
INHBCInhibin subunit beta C. (379 aa)
msx1Muscle segment homeobox 1a. (283 aa)
LOC105015086Nodal-related 1. (411 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
LOC105016079Left-right determination factor. (359 aa)
ENSELUP00000034469V-ski avian sarcoma viral oncogene homolog a. (713 aa)
skilSKI-like proto-oncogene a. (763 aa)
bmp3Bone morphogenetic protein 3. (490 aa)
hpgd15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
LOC105028221Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (187 aa)
LOC105012052Bone morphogenetic protein 16. (466 aa)
gdf5Growth differentiation factor 5. (538 aa)
TMEM100Transmembrane protein 100. (138 aa)
bmpr1aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
LOC105011541RGM domain family, member D. (458 aa)
LOC105028753Leucine rich repeat containing 32. (725 aa)
gdf11Growth differentiation factor 11. (389 aa)
LOC105013596Mothers against decapentaplegic homolog. (425 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (683 aa)
LOC105021125Protein phosphatase, Mg2+/Mn2+ dependent, 1La. (362 aa)
LOC105009048TGF_BETA_2 domain-containing protein. (216 aa)
tgfbr3Transforming growth factor, beta receptor III. (845 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (793 aa)
ENSELUP00000001341Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
nrrosNegative regulator of reactive oxygen species. (700 aa)
Magi2PDZ domain-containing protein. (143 aa)
bmp15Bone morphogenetic protein 15. (465 aa)
ccdc142Coiled-coil domain containing 142. (915 aa)
smad2Mothers against decapentaplegic homolog. (594 aa)
bmp2Bone morphogenetic protein 2b. (419 aa)
mstnMyostatin b. (376 aa)
nodalNodal-related 2. (401 aa)
LOC105027013Southpaw. (423 aa)
ENSELUP00000014068Uncharacterized protein. (1844 aa)
ENSELUP00000014330SMAD family member 1. (231 aa)
SMAD1-2SMAD family member 1. (218 aa)
LOC105022886Anti-dorsalizing morphogenic protein. (398 aa)
LOC105020506JunE proto-oncogene, AP-1 transcription factor subunit. (356 aa)
gdf3Growth differentiation factor 3. (377 aa)
LOC105011631Leupaxin. (448 aa)
LOC105024259Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (498 aa)
inhaInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (354 aa)
LOC105020592RNA binding motif protein 4.3. (344 aa)
LOC105025159Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
LOC105019986Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
tgfb1i1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa)
LOC105019479Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
LOC105014199Paxillin b. (1132 aa)
yap1Yes-associated protein 1. (441 aa)
pxnPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
ppm1lProtein phosphatase, Mg2+/Mn2+ dependent 1L. (365 aa)
SMAD3Mothers against decapentaplegic homolog. (382 aa)
LOC105008258Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (477 aa)
LOC105014505Mothers against decapentaplegic homolog. (467 aa)
smad6Mothers against decapentaplegic homolog. (490 aa)
FAM83GFamily with sequence similarity 83 member G. (1040 aa)
LOC105022549Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
ENSELUP00000036872Golgi glycoprotein 1b. (1143 aa)
ENSELUP00000037263Family with sequence similarity 83 member G. (855 aa)
fkbp8Peptidylprolyl isomerase. (402 aa)
amhAnti-Mullerian hormone. (574 aa)
sostdc1Sclerostin domain containing 1a. (218 aa)
flcnFolliculin. (557 aa)
ENSELUP00000015901Mothers against decapentaplegic homolog. (551 aa)
LOC105017213Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (530 aa)
LOC105022528Myostatin a. (365 aa)
LOC105030895Bone morphogenetic protein 7b. (428 aa)
lef1Lymphoid enhancer-binding factor 1. (374 aa)
npntNephronectin a. (520 aa)
ENSELUP00000017609Zyxin. (560 aa)
INHBBInhibin subunit beta B. (396 aa)
ENSELUP00000018634Uncharacterized protein. (119 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
LOC105025942Ventral homeobox. (269 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (795 aa)
LOC105026156Uncharacterized protein. (668 aa)
LOC105011191Zgc:56585; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (294 aa)
LOC105028705Peptidylprolyl isomerase. (462 aa)
appl1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (711 aa)
SMAD4Mothers against decapentaplegic homolog. (509 aa)
LOC105010856Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
bmp5Bone morphogenetic protein 5. (457 aa)
LOC105024537TGF_BETA_2 domain-containing protein. (373 aa)
bmp6Bone morphogenetic protein 6. (426 aa)
LOC105030804Growth differentiation factor 6a. (413 aa)
bmpr1bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
tab1TGF-beta activated kinase 1/MAP3K7 binding protein 1. (523 aa)
ENSELUP00000021915Jade family PHD finger 2. (678 aa)
LOC105013587Mothers against decapentaplegic homolog. (508 aa)
LOC105027026Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
smad5Mothers against decapentaplegic homolog. (467 aa)
LOC105020594RNA binding motif protein 4.3. (348 aa)
LOC105020595Uncharacterized protein. (349 aa)
ENSELUP00000023671Bone morphogenetic protein 8a. (471 aa)
pdcd4Programmed cell death 4b. (475 aa)
LOC105028827V-ski avian sarcoma viral oncogene homolog b. (648 aa)
LOC105025164Mothers against decapentaplegic homolog. (598 aa)
LOC105025165Bone morphogenetic protein 10, like. (471 aa)
LOC105012389Sclerostin domain containing 1b. (224 aa)
LOC105026064Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (581 aa)
LOC105021940Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2362 aa)
LOC105029333Programmed cell death 4a. (485 aa)
LOC105010781Spartin b. (628 aa)
LOC105009031Uncharacterized protein. (1377 aa)
magi2Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1102 aa)
LOC105020079Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1007 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
LOC105014363Bone morphogenetic protein 10. (494 aa)
gdf10Growth differentiation factor 10b. (445 aa)
LOC109615754TGF_BETA_2 domain-containing protein. (391 aa)
smpd3Sphingomyelin phosphodiesterase 3, neutral. (657 aa)
LOC105030836TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
rgmbRepulsive guidance molecule BMP co-receptor b. (464 aa)
LOC105024057Uncharacterized protein. (324 aa)
ENSELUP00000010618Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (930 aa)
LOC105027755BHLH domain-containing protein. (126 aa)
ENSELUP00000010474Inositol polyphosphate phosphatase-like 1a. (998 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (494 aa)
gdf6Growth differentiation factor 6b. (409 aa)
LOC105028100Left-right determination factor. (363 aa)
ENSELUP00000010012ZP domain-containing protein. (831 aa)
LOC105027242TGF_BETA_2 domain-containing protein. (517 aa)
bmperBMP binding endothelial regulator. (686 aa)
LOC105013159E3 ubiquitin-protein ligase. (772 aa)
ENSELUP00000008164Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
slc33a1Solute carrier family 33 member 1. (547 aa)
LOC105026733Transforming growth factor beta; Belongs to the TGF-beta family. (434 aa)
LOC105031060Mothers against decapentaplegic homolog. (564 aa)
gdf7Growth differentiation factor 7. (442 aa)
inhbbInhibin subunit beta B. (407 aa)
hjvHemojuvelin BMP co-receptor. (427 aa)
LOC105021636E3 ubiquitin-protein ligase. (791 aa)
LOC105011734Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (290 aa)
SMAD1Mothers against decapentaplegic homolog. (474 aa)
tbx2T-box transcription factor 2b. (695 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (655 aa)
LOC105030502Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
LOC105006568Growth differentiation factor 2. (414 aa)
LOC105017334Bone morphogenetic protein 7a. (427 aa)
LOC105025163Inhibin subunit beta Ab. (428 aa)
id1DNA-binding protein inhibitor ID-1. (130 aa)
ENSELUP00000003897EGF-like domain-containing protein. (420 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC105019845USP domain-containing protein; Belongs to the peptidase C19 family. (2592 aa)
LOC105028288Inhibin subunit beta Aa. (396 aa)
LOC105026675Teratocarcinoma-derived growth factor 1. (208 aa)
LOC105016248Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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