STRINGSTRING
hells hells mcm7 mcm7 ENSELUP00000042106 ENSELUP00000042106 LOC105011230 LOC105011230 aire aire mcm4 mcm4 xrcc6 xrcc6 ENSELUP00000039322 ENSELUP00000039322 dmc1 dmc1 shprh shprh btaf1 btaf1 LOC105018167 LOC105018167 smc6 smc6 ENSELUP00000038206 ENSELUP00000038206 ercc2 ercc2 pms2 pms2 chd2 chd2 wrn wrn recql5 recql5 ENSELUP00000037121 ENSELUP00000037121 ruvbl1 ruvbl1 hltf hltf ENSELUP00000033878 ENSELUP00000033878 RAD54L2 RAD54L2 dhx9 dhx9 chd5 chd5 ENSELUP00000032389 ENSELUP00000032389 twnk twnk mcm5 mcm5 msh5 msh5 LOC105026975 LOC105026975 ENSELUP00000031830 ENSELUP00000031830 rad54b rad54b top2b top2b mcm3 mcm3 rfc3 rfc3 ENSELUP00000030130 ENSELUP00000030130 ddx1 ddx1 fbh1 fbh1 chd9 chd9 LOC105021611 LOC105021611 ercc3 ercc3 LOC105026399 LOC105026399 chd7 chd7 Msh3 Msh3 ascc3 ascc3 ENSELUP00000024408 ENSELUP00000024408 smc3 smc3 recql4 recql4 ddx11 ddx11 LOC105025851 LOC105025851 mcm9 mcm9 ENSELUP00000021469 ENSELUP00000021469 ENSELUP00000021334 ENSELUP00000021334 wrnip1 wrnip1 ENSELUP00000020281 ENSELUP00000020281 pif1 pif1 rad51d rad51d LOC105014983 LOC105014983 blm blm mcm2 mcm2 LOC105015403 LOC105015403 Hfm1 Hfm1 supv3l1 supv3l1 smarcad1 smarcad1 DNA2 DNA2 chd1 chd1 LOC105011061 LOC105011061 XRCC2 XRCC2 spo11 spo11 ENSELUP00000016759 ENSELUP00000016759 ENSELUP00000015834 ENSELUP00000015834 SMARCA5 SMARCA5 LOC105024246 LOC105024246 zranb3 zranb3 pms1 pms1 kiaa1257 kiaa1257 mcm8 mcm8 helb helb rad51c rad51c mlh1 mlh1 recql recql top2a top2a LOC105028962 LOC105028962 smarcal1 smarcal1 msh6 msh6 LOC105027427 LOC105027427 smarca4 smarca4 ercc6 ercc6 dhx36 dhx36 LOC105007933 LOC105007933 ENSELUP00000008155 ENSELUP00000008155 rad51b rad51b LOC105013139 LOC105013139 ruvbl2 ruvbl2 ercc6l ercc6l LOC105016382 LOC105016382 mlh3 mlh3 rad17 rad17 ENSELUP00000005976 ENSELUP00000005976 xrcc3 xrcc3 LOC105010544 LOC105010544 lg04h11orf80 lg04h11orf80 ttf2 ttf2 mcm6 mcm6 Atrx Atrx rad51 rad51 knl1 knl1 rtel1 rtel1 gtf2f2 gtf2f2 MPHOSPH9 MPHOSPH9 msh2 msh2 rad54l rad54l ercc6l2 ercc6l2 ENSELUP00000000495 ENSELUP00000000495
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hellsHelicase, lymphoid specific. (856 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (730 aa)
ENSELUP00000042106Immunoglobulin mu DNA binding protein 2. (965 aa)
LOC105011230RAD50 homolog, double strand break repair protein. (1314 aa)
aireAutoimmune regulator. (445 aa)
mcm4DNA helicase; Belongs to the MCM family. (858 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
ENSELUP00000039322Chromodomain helicase DNA binding protein 3. (1567 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
shprhSNF2 histone linker PHD RING helicase. (1626 aa)
btaf1BTAF1 RNA polymerase II, B-TFIID transcription factor-associated. (1834 aa)
LOC105018167CECR2 histone acetyl-lysine reader. (1194 aa)
smc6Si:dkey-119f1.1. (1078 aa)
ENSELUP00000038206Uncharacterized protein. (1826 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
pms2PMS1 homolog 2, mismatch repair system component. (918 aa)
chd2Chromodomain helicase DNA binding protein 2. (1824 aa)
wrnWRN RecQ like helicase. (1484 aa)
recql5RecQ helicase-like 5. (1029 aa)
ENSELUP00000037121Chromodomain helicase DNA binding protein 1-like. (980 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
hltfHelicase-like transcription factor. (952 aa)
ENSELUP00000033878Chromodomain helicase DNA binding protein 6. (2063 aa)
RAD54L2RAD54 like 2. (1421 aa)
dhx9DEAH (Asp-Glu-Ala-His) box helicase 9. (1270 aa)
chd5Chromodomain helicase DNA binding protein 5. (1804 aa)
ENSELUP00000032389Uncharacterized protein. (476 aa)
twnkTwinkle mtDNA helicase. (750 aa)
mcm5DNA helicase; Belongs to the MCM family. (739 aa)
msh5MutS homolog 5. (750 aa)
LOC105026975Uncharacterized protein. (1586 aa)
ENSELUP00000031830RAD54 like 2. (857 aa)
rad54bRAD54 homolog B. (930 aa)
top2bDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1612 aa)
mcm3DNA helicase; Belongs to the MCM family. (812 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
ddx1DEAD (Asp-Glu-Ala-Asp) box helicase 1. (741 aa)
fbh1F-box DNA helicase 1. (1030 aa)
chd9Chromodomain helicase DNA binding protein 9. (2517 aa)
LOC105021611Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2588 aa)
ercc3Excision repair cross-complementation group 3. (785 aa)
LOC105026399DNA helicase; Belongs to the MCM family. (813 aa)
chd7Chromodomain helicase DNA binding protein 7. (2804 aa)
Msh3MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (931 aa)
ascc3Activating signal cointegrator 1 complex subunit 3. (2212 aa)
ENSELUP00000024408Uncharacterized protein. (1479 aa)
smc3Structural maintenance of chromosomes protein. (1216 aa)
recql4RecQ helicase-like 4. (1558 aa)
ddx11DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (900 aa)
LOC105025851Chromodomain helicase DNA binding protein 4a. (1825 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1418 aa)
ENSELUP00000021469INO80 complex ATPase subunit. (1485 aa)
ENSELUP00000021334E1A binding protein p400. (2826 aa)
wrnip1WRN helicase interacting protein 1. (615 aa)
ENSELUP00000020281Uncharacterized protein. (117 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (682 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa)
LOC105014983Uncharacterized protein. (981 aa)
blmBLM RecQ like helicase. (1473 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
LOC105015403Structural maintenance of chromosomes 6. (1082 aa)
Hfm1Helicase for meiosis 1. (933 aa)
supv3l1SUV3-like helicase. (779 aa)
smarcad1Uncharacterized protein. (1017 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
chd1Chromodomain helicase DNA binding protein 1. (1821 aa)
LOC105011061Remodeling and spacing factor 1b, tandem duplicate 1. (1807 aa)
XRCC2X-ray repair cross complementing 2. (316 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (428 aa)
ENSELUP00000016759Uncharacterized protein. (101 aa)
ENSELUP00000015834Uncharacterized protein. (1794 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (982 aa)
LOC105024246DNA helicase; Belongs to the MCM family. (823 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1168 aa)
pms1PMS1 homolog 1, mismatch repair system component. (911 aa)
kiaa1257Si:dkey-57n24.6. (1212 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (820 aa)
helbHelicase (DNA) B. (1242 aa)
rad51cRAD51 paralog C. (359 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (715 aa)
recqlATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (834 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1504 aa)
LOC105028962SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1021 aa)
smarcal1Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (1041 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1387 aa)
LOC105027427SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1577 aa)
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a. (1636 aa)
ercc6Excision repair cross-complementation group 6. (1494 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1050 aa)
LOC105007933Snf2-related CREBBP activator protein. (2881 aa)
ENSELUP00000008155DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
rad51bRAD51 paralog B. (378 aa)
LOC105013139ATPase family AAA domain containing 5a. (1854 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
ercc6lExcision repair cross-complementation group 6-like. (1302 aa)
LOC105016382General transcription factor IIF, polypeptide 2b. (248 aa)
mlh3MutL homolog 3 (E. coli). (1272 aa)
rad17RAD17 checkpoint clamp loader component. (699 aa)
ENSELUP00000005976BRCA1 interacting protein C-terminal helicase 1. (941 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
LOC105010544PHD-type domain-containing protein. (1344 aa)
lg04h11orf80Uncharacterized protein. (459 aa)
ttf2Uncharacterized protein. (1098 aa)
mcm6DNA helicase; Belongs to the MCM family. (821 aa)
AtrxATRX chromatin remodeler. (2039 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
knl1Knl1_RWD_C domain-containing protein. (1650 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1198 aa)
gtf2f2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (275 aa)
MPHOSPH9Uncharacterized protein. (1375 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (962 aa)
rad54lRAD54 like. (745 aa)
ercc6l2Excision repair cross-complementation group 6-like 2. (1496 aa)
ENSELUP00000000495Helicase, POLQ like. (980 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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