45 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wrn	WRN RecQ like helicase. (1484 aa)
	LOC105024905	CCR4-NOT transcription complex, subunit 6a. (557 aa)
	rad9b	RAD9 checkpoint clamp component B. (383 aa)
	angel2	Angel homolog 2 (Drosophila). (607 aa)
	ENSELUP00000039300	Uncharacterized protein. (94 aa)
	LRRC27	Leucine rich repeat containing 27. (474 aa)
	parn	Poly(A)-specific ribonuclease (deadenylation nuclease). (754 aa)
	exosc10	Exosome component 10. (900 aa)
	toe1	Target of EGR1, exonuclease. (527 aa)
	ENSELUP00000033211	Nocturnin. (430 aa)
	usb1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (273 aa)
	trir	Telomerase RNA component interacting RNase. (151 aa)
	exd3	Exonuclease 3'-5' domain containing 3. (885 aa)
	angel1	Angel homolog 1 (Drosophila). (683 aa)
	rad9a	RAD9 checkpoint clamp component A. (352 aa)
	pan2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1208 aa)
	eri1	Exoribonuclease 1. (341 aa)
	ENSELUP00000025085	Uncharacterized protein. (160 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1056 aa)
	exd2	Exonuclease 3'-5' domain containing 2. (660 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (312 aa)
	apex2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (582 aa)
	rexo2	Small fragment nuclease. (289 aa)
	dis3l	DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1070 aa)
	meiob	Methionine sulfoxide reductase B1b. (471 aa)
	ENSELUP00000018284	Endo/exonuclease/phosphatase domain-containing protein. (185 aa)
	tatdn1	TatD DNase domain containing 1. (323 aa)
	LOC105025822	Endo/exonuclease/phosphatase domain-containing protein. (568 aa)
	pde12	Phosphodiesterase 12. (597 aa)
	ENSELUP00000013560	zf-GRF domain-containing protein. (667 aa)
	cnot6l	CCR4-NOT transcription complex, subunit 6-like. (629 aa)
	pold1	DNA polymerase. (1105 aa)
	APLF	Aprataxin and PNKP like factor. (513 aa)
	cnot8	CCR4-NOT transcription complex, subunit 8. (285 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
	LOC105026542	CCR4-NOT transcription complex, subunit 7. (286 aa)
	ENSELUP00000008653	Uncharacterized protein. (305 aa)
	rad1	Cell cycle checkpoint protein RAD1. (280 aa)
	exd1	3'-5' exonuclease domain-containing protein. (572 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (770 aa)
	rexo4	REX4 homolog, 3'-5' exonuclease. (483 aa)
	polg	Polymerase (DNA directed), gamma. (1211 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
	LOC105029048	Nocturnin. (461 aa)
	dis3	DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (952 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	wrn	ENSELUP00000011463	ENSELUP00000038002	Aprataxin and PNKP like factor.	WRN RecQ like helicase.	0.640
ENSELUP00000008653	mre11	ENSELUP00000008653	ENSELUP00000010046	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.401
ENSELUP00000008653	pold1	ENSELUP00000008653	ENSELUP00000013108	Uncharacterized protein.	DNA polymerase.	0.593
ENSELUP00000008653	pole	ENSELUP00000008653	ENSELUP00000001770	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.607
ENSELUP00000008653	wrn	ENSELUP00000008653	ENSELUP00000038002	Uncharacterized protein.	WRN RecQ like helicase.	0.485
ENSELUP00000013560	eri1	ENSELUP00000013560	ENSELUP00000025659	zf-GRF domain-containing protein.	Exoribonuclease 1.	0.532
ENSELUP00000018284	mre11	ENSELUP00000018284	ENSELUP00000010046	Endo/exonuclease/phosphatase domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.401
ENSELUP00000018284	pold1	ENSELUP00000018284	ENSELUP00000013108	Endo/exonuclease/phosphatase domain-containing protein.	DNA polymerase.	0.593
ENSELUP00000018284	pole	ENSELUP00000018284	ENSELUP00000001770	Endo/exonuclease/phosphatase domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.607
ENSELUP00000018284	wrn	ENSELUP00000018284	ENSELUP00000038002	Endo/exonuclease/phosphatase domain-containing protein.	WRN RecQ like helicase.	0.485
ENSELUP00000025085	mre11	ENSELUP00000025085	ENSELUP00000010046	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.401
ENSELUP00000025085	pold1	ENSELUP00000025085	ENSELUP00000013108	Uncharacterized protein.	DNA polymerase.	0.593
ENSELUP00000025085	pole	ENSELUP00000025085	ENSELUP00000001770	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.607
ENSELUP00000025085	wrn	ENSELUP00000025085	ENSELUP00000038002	Uncharacterized protein.	WRN RecQ like helicase.	0.485
ENSELUP00000033211	LOC105026542	ENSELUP00000033211	ENSELUP00000009302	Nocturnin.	CCR4-NOT transcription complex, subunit 7.	0.780
ENSELUP00000033211	cnot8	ENSELUP00000033211	ENSELUP00000010397	Nocturnin.	CCR4-NOT transcription complex, subunit 8.	0.780
ENSELUP00000033211	pan2	ENSELUP00000033211	ENSELUP00000025731	Nocturnin.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.515
ENSELUP00000033211	parn	ENSELUP00000033211	ENSELUP00000034535	Nocturnin.	Poly(A)-specific ribonuclease (deadenylation nuclease).	0.481
ENSELUP00000039300	mre11	ENSELUP00000039300	ENSELUP00000010046	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.401
ENSELUP00000039300	pold1	ENSELUP00000039300	ENSELUP00000013108	Uncharacterized protein.	DNA polymerase.	0.593