8 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ticrr	Treslin_N domain-containing protein. (1814 aa)
	rad17	RAD17 checkpoint clamp loader component. (699 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1493 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (568 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (283 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
	CLSPN	Claspin. (1126 aa)
	ENSELUP00000037811	BRCT domain-containing protein. (139 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	ENSELUP00000037811	ENSELUP00000025081	ENSELUP00000037811	Claspin.	BRCT domain-containing protein.	0.830
CLSPN	Ticrr	ENSELUP00000025081	ENSELUP00000001808	Claspin.	Treslin_N domain-containing protein.	0.641
CLSPN	cdc6	ENSELUP00000025081	ENSELUP00000009381	Claspin.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.866
CLSPN	hus1	ENSELUP00000025081	ENSELUP00000016476	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.649
CLSPN	orc1	ENSELUP00000025081	ENSELUP00000022164	Claspin.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.881
CLSPN	rad17	ENSELUP00000025081	ENSELUP00000006178	Claspin.	RAD17 checkpoint clamp loader component.	0.680
CLSPN	topbp1	ENSELUP00000025081	ENSELUP00000007643	Claspin.	DNA topoisomerase II binding protein 1.	0.874
ENSELUP00000037811	CLSPN	ENSELUP00000037811	ENSELUP00000025081	BRCT domain-containing protein.	Claspin.	0.830
ENSELUP00000037811	Ticrr	ENSELUP00000037811	ENSELUP00000001808	BRCT domain-containing protein.	Treslin_N domain-containing protein.	0.822
ENSELUP00000037811	cdc6	ENSELUP00000037811	ENSELUP00000009381	BRCT domain-containing protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.652
ENSELUP00000037811	hus1	ENSELUP00000037811	ENSELUP00000016476	BRCT domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.889
ENSELUP00000037811	rad17	ENSELUP00000037811	ENSELUP00000006178	BRCT domain-containing protein.	RAD17 checkpoint clamp loader component.	0.901
Ticrr	CLSPN	ENSELUP00000001808	ENSELUP00000025081	Treslin_N domain-containing protein.	Claspin.	0.641
Ticrr	ENSELUP00000037811	ENSELUP00000001808	ENSELUP00000037811	Treslin_N domain-containing protein.	BRCT domain-containing protein.	0.822
Ticrr	cdc6	ENSELUP00000001808	ENSELUP00000009381	Treslin_N domain-containing protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.592
Ticrr	topbp1	ENSELUP00000001808	ENSELUP00000007643	Treslin_N domain-containing protein.	DNA topoisomerase II binding protein 1.	0.899
cdc6	CLSPN	ENSELUP00000009381	ENSELUP00000025081	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Claspin.	0.866
cdc6	ENSELUP00000037811	ENSELUP00000009381	ENSELUP00000037811	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	BRCT domain-containing protein.	0.652
cdc6	Ticrr	ENSELUP00000009381	ENSELUP00000001808	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Treslin_N domain-containing protein.	0.592
cdc6	orc1	ENSELUP00000009381	ENSELUP00000022164	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999