STRINGSTRING
LOC105027064 LOC105027064 LOC105014148 LOC105014148 mtrr mtrr ENSELUP00000002764 ENSELUP00000002764 dglucy dglucy dlst dlst LOC105007677 LOC105007677 gclm gclm hal hal grhpr grhpr sdhaf3 sdhaf3 OGDH OGDH mrps36 mrps36 iffo2 iffo2 ALDH18A1 ALDH18A1 LOC105025036 LOC105025036 ENSELUP00000011555 ENSELUP00000011555 mdh1 mdh1 tat tat nags nags acot8 acot8 LOC105026321 LOC105026321 LOC105006550 LOC105006550 oat oat LOC105019574 LOC105019574 GLS GLS ftcd ftcd nit2 nit2 LOC105023465 LOC105023465 ENSELUP00000018608 ENSELUP00000018608 ACSF3 ACSF3 aldh1l2 aldh1l2 idh2 idh2 ddo ddo kmo kmo GOT1 GOT1 fpgs fpgs LOC105016560 LOC105016560 pck2 pck2 got1 got1 mdh1b mdh1b d2hgdh d2hgdh LOC105015304 LOC105015304 LOC105020027 LOC105020027 amdhd1 amdhd1 LOC105017435 LOC105017435 LOC105018399 LOC105018399 mthfd1 mthfd1 aadat aadat idh1 idh1 LOC105020203 LOC105020203 LOC105006218 LOC105006218 QPRT QPRT ftcdnl1 ftcdnl1 aldh5a1 aldh5a1 adhfe1 adhfe1 pck1 pck1 LOC105016125 LOC105016125 mdh2 mdh2 LOC105024789 LOC105024789 LOC105008309 LOC105008309 kynu kynu haao haao LOC105022529 LOC105022529 LOC105021712 LOC105021712 fh fh mthfd1l mthfd1l LOC105016647 LOC105016647 ACLY ACLY LOC105026161 LOC105026161 Shmt2 Shmt2 prodh2 prodh2 LOC105007068 LOC105007068 gclc gclc me2 me2 me1 me1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105027064Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (639 aa)
LOC105014148Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (542 aa)
mtrr5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (796 aa)
ENSELUP00000002764Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (407 aa)
dglucyD-glutamate cyclase. (670 aa)
dlstDihydrolipoamide S-succinyltransferase. (522 aa)
LOC105007677Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (788 aa)
gclmGlutamate-cysteine ligase, modifier subunit. (274 aa)
halHistidine ammonia-lyase; Belongs to the PAL/histidase family. (651 aa)
grhprGlyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa)
sdhaf3ACN9 protein homolog, mitochondrial. (125 aa)
OGDHOxoglutarate dehydrogenase. (1049 aa)
mrps36Mitochondrial ribosomal protein S36. (118 aa)
iffo2Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (564 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (776 aa)
LOC105025036Zgc:113208. (280 aa)
ENSELUP00000011555Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (446 aa)
mdh1Malate dehydrogenase. (350 aa)
tatTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (468 aa)
nagsN-acetylglutamate synthase. (522 aa)
acot8Acyl-CoA thioesterase 8. (385 aa)
LOC105026321Glutaminase 2a (liver, mitochondrial). (608 aa)
LOC105006550Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
oatOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
LOC105019574Si:ch211-217a12.1. (504 aa)
GLSGlutaminase. (650 aa)
ftcdFormimidoyltransferase cyclodeaminase. (540 aa)
nit2CN hydrolase domain-containing protein. (284 aa)
LOC105023465Aspartate aminotransferase. (427 aa)
ENSELUP00000018608Uncharacterized protein. (71 aa)
ACSF3Acyl-CoA synthetase family member 3. (573 aa)
aldh1l210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
ddoZgc:172341. (339 aa)
kmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (463 aa)
GOT1Aspartate aminotransferase. (410 aa)
fpgsFolylpolyglutamate synthase. (653 aa)
LOC105016560Malic enzyme. (615 aa)
pck2Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (638 aa)
got1Aspartate aminotransferase. (410 aa)
mdh1bMalate dehydrogenase 1B, NAD (soluble). (524 aa)
d2hgdhD-2-hydroxyglutarate dehydrogenase. (538 aa)
LOC105015304Oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (1023 aa)
LOC105020027Glutamic pyruvate transaminase (alanine aminotransferase) 2, like. (544 aa)
amdhd1Amidohydrolase domain containing 1. (430 aa)
LOC1050174352-epi-5-epi-valiolone synthase. (440 aa)
LOC105018399Glutaminase like. (594 aa)
mthfd1Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (954 aa)
aadatAminoadipate aminotransferase. (435 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (470 aa)
LOC105020203Histidine ammonia-lyase; Belongs to the PAL/histidase family. (553 aa)
LOC105006218Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (352 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (303 aa)
ftcdnl1Zgc:153901. (421 aa)
aldh5a1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
adhfe1Alcohol dehydrogenase iron containing 1. (464 aa)
pck1Phosphoenolpyruvate carboxykinase 1 (soluble). (616 aa)
LOC105016125Aspartate aminotransferase. (428 aa)
mdh2Malate dehydrogenase. (341 aa)
LOC10502478910-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
LOC105008309Malate dehydrogenase. (334 aa)
kynuKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (503 aa)
haao3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
LOC105022529Glutaminase a. (649 aa)
LOC105021712Uncharacterized protein. (824 aa)
fhFumarate hydratase. (504 aa)
mthfd1lMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (1075 aa)
LOC105016647Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (453 aa)
ACLYATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1102 aa)
LOC105026161Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
Shmt2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
prodh2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (472 aa)
LOC105007068Glutaminase 2b (liver, mitochondrial). (610 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (629 aa)
me2Malic enzyme. (582 aa)
me1Malic enzyme. (588 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
Server load: low (12%) [HD]