64 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105017690	Checkpoint suppressor 1. (463 aa)
	Ticrr	Treslin_N domain-containing protein. (1814 aa)
	ENSELUP00000001840	Checkpoint kinase 1. (382 aa)
	chek2	Checkpoint kinase 2. (513 aa)
	ENSELUP00000002658	WW domain containing adaptor with coiled-coil a. (527 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	ENSELUP00000004782	Protein kinase domain-containing protein. (982 aa)
	brca1	Uncharacterized protein. (1565 aa)
	rad9b	RAD9 checkpoint clamp component B. (383 aa)
	ENSELUP00000042673	P53-induced death domain protein 1. (868 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (590 aa)
	LOC105024368	Protein kinase domain-containing protein. (1296 aa)
	Ier3	Uncharacterized protein. (138 aa)
	ENSELUP00000040863	Uncharacterized protein. (93 aa)
	LOC105023190	TAO kinase 1a. (1067 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (454 aa)
	babam1	BRISC and BRCA1 A complex member 1. (367 aa)
	ENSELUP00000037811	BRCT domain-containing protein. (139 aa)
	LOC105006381	G-2 and S-phase expressed 1. (753 aa)
	LOC105024996	WW domain-containing protein. (511 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4077 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (617 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (505 aa)
	Eme2	ERCC4 domain-containing protein. (331 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (570 aa)
	rfwd3	Ring finger and WD repeat domain 3. (741 aa)
	taok3	TAO kinase 3a. (898 aa)
	DONSON	Downstream neighbor of SON. (603 aa)
	LOC105017441	SET domain and mariner transposase fusion gene. (299 aa)
	LOC105022022	Fizzy/cell division cycle 20 related 1b. (516 aa)
	fbxo31	F-box protein 31. (557 aa)
	rad9a	RAD9 checkpoint clamp component A. (352 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (404 aa)
	CLSPN	Claspin. (1126 aa)
	cdca7	Cell division cycle associated 7a. (419 aa)
	mrnip	Uncharacterized protein. (385 aa)
	LOC105014913	TAO kinase 3b. (407 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
	LOC105013234	Uncharacterized protein. (462 aa)
	Tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (327 aa)
	blm	BLM RecQ like helicase. (1473 aa)
	atm	Non-specific serine/threonine protein kinase. (3011 aa)
	fancd2	FA complementation group D2. (1408 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (452 aa)
	foxn3	Forkhead box N3. (494 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (443 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (283 aa)
	babam2	BRISC and BRCA1 A complex member 2. (413 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (676 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (931 aa)
	uimc1	RAP80_UIM domain-containing protein. (1224 aa)
	nbn	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
	rint1	RAD50 interactor 1. (793 aa)
	LOC105018279	Cyclin D1; Belongs to the cyclin family. (502 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (568 aa)
	LOC105011710	Fizzy/cell division cycle 20 related 1a. (495 aa)
	taok2	TAO kinase 2a. (1154 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1493 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (962 aa)
	LOC105027836	CASP2 and RIPK1 domain containing adaptor with death domain. (203 aa)
	rad17	RAD17 checkpoint clamp loader component. (699 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	ENSELUP00000001840	ENSELUP00000025081	ENSELUP00000001840	Claspin.	Checkpoint kinase 1.	0.988
CLSPN	ENSELUP00000037811	ENSELUP00000025081	ENSELUP00000037811	Claspin.	BRCT domain-containing protein.	0.830
CLSPN	Ticrr	ENSELUP00000025081	ENSELUP00000001808	Claspin.	Treslin_N domain-containing protein.	0.641
CLSPN	Tipin	ENSELUP00000025081	ENSELUP00000020179	Claspin.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.909
CLSPN	atm	ENSELUP00000025081	ENSELUP00000019434	Claspin.	Non-specific serine/threonine protein kinase.	0.597
CLSPN	blm	ENSELUP00000025081	ENSELUP00000019791	Claspin.	BLM RecQ like helicase.	0.584
CLSPN	brca1	ENSELUP00000025081	ENSELUP00000006103	Claspin.	Uncharacterized protein.	0.790
CLSPN	casp2	ENSELUP00000025081	ENSELUP00000017444	Claspin.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.537
CLSPN	cdc6	ENSELUP00000025081	ENSELUP00000009381	Claspin.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.866
CLSPN	cdca7	ENSELUP00000025081	ENSELUP00000023624	Claspin.	Cell division cycle associated 7a.	0.551
CLSPN	cdk1	ENSELUP00000025081	ENSELUP00000004198	Claspin.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.589
CLSPN	chek2	ENSELUP00000025081	ENSELUP00000002038	Claspin.	Checkpoint kinase 2.	0.597
CLSPN	fancd2	ENSELUP00000025081	ENSELUP00000018341	Claspin.	FA complementation group D2.	0.627
CLSPN	hus1	ENSELUP00000025081	ENSELUP00000016476	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.649
CLSPN	orc1	ENSELUP00000025081	ENSELUP00000022164	Claspin.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.881
CLSPN	rad17	ENSELUP00000025081	ENSELUP00000006178	Claspin.	RAD17 checkpoint clamp loader component.	0.680
CLSPN	rad9a	ENSELUP00000025081	ENSELUP00000025909	Claspin.	RAD9 checkpoint clamp component A.	0.653
CLSPN	rad9b	ENSELUP00000025081	ENSELUP00000043031	Claspin.	RAD9 checkpoint clamp component B.	0.653
CLSPN	topbp1	ENSELUP00000025081	ENSELUP00000007643	Claspin.	DNA topoisomerase II binding protein 1.	0.874
DONSON	dtl	ENSELUP00000027610	ENSELUP00000013863	Downstream neighbor of SON.	Denticleless E3 ubiquitin protein ligase homolog (Drosophila).	0.495