STRINGSTRING
rad9b rad9b LOC105011762 LOC105011762 tp53bp1 tp53bp1 chek2 chek2 sfrp2 sfrp2 rad51 rad51 brca1 brca1 atr atr brca2 brca2 LOC105016143 LOC105016143 rad1 rad1 ect2 ect2 LOC105024057 LOC105024057 zmpste24 zmpste24 kdm1a kdm1a atm atm itgb6 itgb6 blm blm LOC105010856 LOC105010856 ENSELUP00000021469 ENSELUP00000021469 LOC105027026 LOC105027026 cdca7 cdca7 rad9a rad9a rhno1 rhno1 fbxo4 fbxo4 elk1 elk1 LOC105007215 LOC105007215 Lig4 Lig4 ENSELUP00000032389 ENSELUP00000032389 wrn wrn ccdc51 ccdc51 tank tank tmem109 tmem109 xrcc6 xrcc6 sirt1 sirt1 SPIDR SPIDR map3k20 map3k20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad9bRAD9 checkpoint clamp component B. (383 aa)
LOC105011762Growth arrest and DNA-damage-inducible, alpha, b. (159 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1856 aa)
chek2Checkpoint kinase 2. (513 aa)
sfrp2Secreted frizzled-related protein 2. (292 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
brca1Uncharacterized protein. (1565 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa)
brca2BRCA2 DNA repair associated. (2826 aa)
LOC105016143BRCA1 associated RING domain 1. (809 aa)
rad1Cell cycle checkpoint protein RAD1. (280 aa)
ect2Epithelial cell transforming 2. (988 aa)
LOC105024057Uncharacterized protein. (324 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (825 aa)
atmNon-specific serine/threonine protein kinase. (3011 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (795 aa)
blmBLM RecQ like helicase. (1473 aa)
LOC105010856Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
ENSELUP00000021469INO80 complex ATPase subunit. (1485 aa)
LOC105027026Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
cdca7Cell division cycle associated 7a. (419 aa)
rad9aRAD9 checkpoint clamp component A. (352 aa)
rhno1Si:ch73-352p4.5. (303 aa)
fbxo4F-box protein 4. (382 aa)
elk1ETS transcription factor ELK1. (481 aa)
LOC105007215Protein kinase domain-containing protein. (597 aa)
Lig4DNA ligase. (912 aa)
ENSELUP00000032389Uncharacterized protein. (476 aa)
wrnWRN RecQ like helicase. (1484 aa)
ccdc51Deoxyribonuclease; Belongs to the DNase I family. (266 aa)
tankTRAF family member-associated NFKB activator. (367 aa)
tmem109Uncharacterized protein. (229 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (683 aa)
SPIDRScaffold protein involved in DNA repair. (968 aa)
map3k20Uncharacterized protein. (860 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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