37 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad9b	RAD9 checkpoint clamp component B. (383 aa)
	LOC105011762	Growth arrest and DNA-damage-inducible, alpha, b. (159 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1856 aa)
	chek2	Checkpoint kinase 2. (513 aa)
	sfrp2	Secreted frizzled-related protein 2. (292 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	brca1	Uncharacterized protein. (1565 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa)
	brca2	BRCA2 DNA repair associated. (2826 aa)
	LOC105016143	BRCA1 associated RING domain 1. (809 aa)
	rad1	Cell cycle checkpoint protein RAD1. (280 aa)
	ect2	Epithelial cell transforming 2. (988 aa)
	LOC105024057	Uncharacterized protein. (324 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (825 aa)
	atm	Non-specific serine/threonine protein kinase. (3011 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (795 aa)
	blm	BLM RecQ like helicase. (1473 aa)
	LOC105010856	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	ENSELUP00000021469	INO80 complex ATPase subunit. (1485 aa)
	LOC105027026	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	cdca7	Cell division cycle associated 7a. (419 aa)
	rad9a	RAD9 checkpoint clamp component A. (352 aa)
	rhno1	Si:ch73-352p4.5. (303 aa)
	fbxo4	F-box protein 4. (382 aa)
	elk1	ETS transcription factor ELK1. (481 aa)
	LOC105007215	Protein kinase domain-containing protein. (597 aa)
	Lig4	DNA ligase. (912 aa)
	ENSELUP00000032389	Uncharacterized protein. (476 aa)
	wrn	WRN RecQ like helicase. (1484 aa)
	ccdc51	Deoxyribonuclease; Belongs to the DNase I family. (266 aa)
	tank	TRAF family member-associated NFKB activator. (367 aa)
	tmem109	Uncharacterized protein. (229 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (683 aa)
	SPIDR	Scaffold protein involved in DNA repair. (968 aa)
	map3k20	Uncharacterized protein. (860 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSELUP00000021469	blm	ENSELUP00000021469	ENSELUP00000019791	INO80 complex ATPase subunit.	BLM RecQ like helicase.	0.546
ENSELUP00000021469	rad51	ENSELUP00000021469	ENSELUP00000003394	INO80 complex ATPase subunit.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.481
ENSELUP00000021469	tp53bp1	ENSELUP00000021469	ENSELUP00000001630	INO80 complex ATPase subunit.	Tumor protein p53 binding protein, 1.	0.401
ENSELUP00000021469	wrn	ENSELUP00000021469	ENSELUP00000038002	INO80 complex ATPase subunit.	WRN RecQ like helicase.	0.686
ENSELUP00000032389	LOC105016143	ENSELUP00000032389	ENSELUP00000007718	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.657
ENSELUP00000032389	Lig4	ENSELUP00000032389	ENSELUP00000029768	Uncharacterized protein.	DNA ligase.	0.990
ENSELUP00000032389	atm	ENSELUP00000032389	ENSELUP00000019434	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.944
ENSELUP00000032389	atr	ENSELUP00000032389	ENSELUP00000006242	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.687
ENSELUP00000032389	blm	ENSELUP00000032389	ENSELUP00000019791	Uncharacterized protein.	BLM RecQ like helicase.	0.795
ENSELUP00000032389	brca1	ENSELUP00000032389	ENSELUP00000006103	Uncharacterized protein.	Uncharacterized protein.	0.706
ENSELUP00000032389	brca2	ENSELUP00000032389	ENSELUP00000006490	Uncharacterized protein.	BRCA2 DNA repair associated.	0.595
ENSELUP00000032389	cdca7	ENSELUP00000032389	ENSELUP00000023624	Uncharacterized protein.	Cell division cycle associated 7a.	0.430
ENSELUP00000032389	chek2	ENSELUP00000032389	ENSELUP00000002038	Uncharacterized protein.	Checkpoint kinase 2.	0.612
ENSELUP00000032389	rad51	ENSELUP00000032389	ENSELUP00000003394	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.698
ENSELUP00000032389	rad9a	ENSELUP00000032389	ENSELUP00000025909	Uncharacterized protein.	RAD9 checkpoint clamp component A.	0.461
ENSELUP00000032389	rad9b	ENSELUP00000032389	ENSELUP00000043031	Uncharacterized protein.	RAD9 checkpoint clamp component B.	0.461
ENSELUP00000032389	sirt1	ENSELUP00000032389	ENSELUP00000040662	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.656
ENSELUP00000032389	tp53bp1	ENSELUP00000032389	ENSELUP00000001630	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.848
ENSELUP00000032389	wrn	ENSELUP00000032389	ENSELUP00000038002	Uncharacterized protein.	WRN RecQ like helicase.	0.995
ENSELUP00000032389	xrcc6	ENSELUP00000032389	ENSELUP00000039967	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.999