37 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSELUP00000014017	Tonsoku-like, DNA repair protein. (1323 aa)
	rpa3	Uncharacterized protein. (121 aa)
	wrn	WRN RecQ like helicase. (1484 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
	ENSELUP00000035242	Mcm10 domain-containing protein. (660 aa)
	uhrf1	Ubiquitin-like with PHD and ring finger domains 1. (786 aa)
	dars2	Aspartyl-tRNA synthetase 2, mitochondrial. (677 aa)
	ENSELUP00000031341	DNA polymerase. (1412 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ENSELUP00000030130	Replication factor C subunit 1. (1033 aa)
	ENSELUP00000029732	Minichromosome maintenance 10 replication initiation factor. (781 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (375 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (608 aa)
	primpol	Primase and polymerase (DNA-directed). (592 aa)
	DONSON	Downstream neighbor of SON. (603 aa)
	LOC105028612	Si:dkeyp-11e3.1. (208 aa)
	ENSELUP00000026557	Zf-primase domain-containing protein. (173 aa)
	mms22l	MMS22-like, DNA repair protein. (1239 aa)
	ENSELUP00000022232	Uncharacterized protein. (589 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (520 aa)
	pold4	Si:dkey-28b4.7. (109 aa)
	Tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (327 aa)
	blm	BLM RecQ like helicase. (1473 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (691 aa)
	rpa2	Replication protein A2. (299 aa)
	lg09h19orf53	Zgc:136864. (102 aa)
	zranb3	Zinc finger, RAN-binding domain containing 3. (1168 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1856 aa)
	ENSELUP00000001840	Checkpoint kinase 1. (382 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
	rfc5	AAA domain-containing protein. (335 aa)
	rfc4	Replication factor C (activator 1) 4. (376 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (568 aa)
	radx	RPA1 related single stranded DNA binding protein. (871 aa)
	pold1	DNA polymerase. (1105 aa)
	rfc2	Replication factor C (activator 1) 2. (368 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DONSON	cdt1	ENSELUP00000027610	ENSELUP00000019143	Downstream neighbor of SON.	Chromatin licensing and DNA replication factor 1.	0.469
DONSON	pola2	ENSELUP00000027610	ENSELUP00000028912	Downstream neighbor of SON.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.527
DONSON	pold1	ENSELUP00000027610	ENSELUP00000013108	Downstream neighbor of SON.	DNA polymerase.	0.412
DONSON	pold2	ENSELUP00000027610	ENSELUP00000002587	Downstream neighbor of SON.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.652
DONSON	prim2	ENSELUP00000027610	ENSELUP00000021792	Downstream neighbor of SON.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.710
DONSON	primpol	ENSELUP00000027610	ENSELUP00000028331	Downstream neighbor of SON.	Primase and polymerase (DNA-directed).	0.463
DONSON	rfc3	ENSELUP00000027610	ENSELUP00000030603	Downstream neighbor of SON.	Replication factor C (activator 1) 3.	0.438
DONSON	rfc4	ENSELUP00000027610	ENSELUP00000008564	Downstream neighbor of SON.	Replication factor C (activator 1) 4.	0.656
ENSELUP00000001840	ENSELUP00000026557	ENSELUP00000001840	ENSELUP00000026557	Checkpoint kinase 1.	Zf-primase domain-containing protein.	0.828
ENSELUP00000001840	ENSELUP00000029732	ENSELUP00000001840	ENSELUP00000029732	Checkpoint kinase 1.	Minichromosome maintenance 10 replication initiation factor.	0.828
ENSELUP00000001840	ENSELUP00000031341	ENSELUP00000001840	ENSELUP00000031341	Checkpoint kinase 1.	DNA polymerase.	0.593
ENSELUP00000001840	ENSELUP00000035242	ENSELUP00000001840	ENSELUP00000035242	Checkpoint kinase 1.	Mcm10 domain-containing protein.	0.828
ENSELUP00000001840	Tipin	ENSELUP00000001840	ENSELUP00000020179	Checkpoint kinase 1.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.825
ENSELUP00000001840	blm	ENSELUP00000001840	ENSELUP00000019791	Checkpoint kinase 1.	BLM RecQ like helicase.	0.896
ENSELUP00000001840	cdc6	ENSELUP00000001840	ENSELUP00000009381	Checkpoint kinase 1.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.921
ENSELUP00000001840	cdt1	ENSELUP00000001840	ENSELUP00000019143	Checkpoint kinase 1.	Chromatin licensing and DNA replication factor 1.	0.767
ENSELUP00000001840	mms22l	ENSELUP00000001840	ENSELUP00000022948	Checkpoint kinase 1.	MMS22-like, DNA repair protein.	0.426
ENSELUP00000001840	pola2	ENSELUP00000001840	ENSELUP00000028912	Checkpoint kinase 1.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.418
ENSELUP00000001840	pold1	ENSELUP00000001840	ENSELUP00000013108	Checkpoint kinase 1.	DNA polymerase.	0.717
ENSELUP00000001840	prim2	ENSELUP00000001840	ENSELUP00000021792	Checkpoint kinase 1.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.411