STRINGSTRING
pole pole pold2 pold2 parp2 parp2 adprhl2 adprhl2 rfc5 rfc5 LOC105013139 LOC105013139 pcna pcna rfc4 rfc4 vwa5b2 vwa5b2 pold1 pold1 rfc2 rfc2 ENSELUP00000015817 ENSELUP00000015817 LOC105024976 LOC105024976 pole2 pole2 parp1 parp1 rpa2 rpa2 meiob meiob pold3 pold3 pole3 pole3 pold4 pold4 rpa1 rpa1 apex2 apex2 apex1 apex1 pole4 pole4 LOC105006037 LOC105006037 LOC105015305 LOC105015305 LOC105019838 LOC105019838 LOC105028498 LOC105028498 ENSELUP00000030130 ENSELUP00000030130 rfc3 rfc3 polb polb ENSELUP00000031865 ENSELUP00000031865 lig1 lig1 PARG PARG parp3 parp3 RCBTB1 RCBTB1 fen1 fen1 rpa3 rpa3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
parp2Poly [ADP-ribose] polymerase. (691 aa)
adprhl2ADP-ribosylhydrolase like 2. (378 aa)
rfc5AAA domain-containing protein. (335 aa)
LOC105013139ATPase family AAA domain containing 5a. (1854 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1422 aa)
pold1DNA polymerase. (1105 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
ENSELUP00000015817annotation not available (117 aa)
LOC105024976Zgc:110269. (350 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
rpa2Replication protein A2. (299 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa)
pold4Si:dkey-28b4.7. (109 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (582 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (312 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
LOC105015305Poly (ADP-ribose) glycohydrolase, like. (621 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
ENSELUP00000031865Si:cabz01080528.1. (762 aa)
lig1DNA ligase. (1069 aa)
PARGPoly(ADP-ribose) glycohydrolase. (798 aa)
parp3Poly [ADP-ribose] polymerase. (553 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
rpa3Uncharacterized protein. (121 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.