STRINGSTRING
rpa3 rpa3 gar1 gar1 cdk2 cdk2 fen1 fen1 RCBTB1 RCBTB1 wrn wrn prim1 prim1 chtf8 chtf8 dkc1 dkc1 lig1 lig1 ENSELUP00000031341 ENSELUP00000031341 nop10 nop10 rfc3 rfc3 terf1 terf1 ENSELUP00000030130 ENSELUP00000030130 LOC105028498 LOC105028498 ankrd44 ankrd44 pola2 pola2 LOC105019838 LOC105019838 tinf2 tinf2 shq1 shq1 LOC105026040 LOC105026040 wrap53 wrap53 dscc1 dscc1 LOC105006037 LOC105006037 exd2 exd2 recql4 recql4 nhp2 nhp2 rpa1 rpa1 prim2 prim2 pold4 pold4 ppp6c ppp6c pif1 pif1 blm blm pold3 pold3 ankrd66 ankrd66 meiob meiob LOC105012459 LOC105012459 LOC105022303 LOC105022303 rtel1 rtel1 pold2 pold2 rfc5 rfc5 stn1 stn1 pot1 pot1 ankrd28 ankrd28 ten1 ten1 ruvbl2 ruvbl2 pcna pcna ccna1 ccna1 rfc4 rfc4 LOC105016238 LOC105016238 pold1 pold1 Trub1 Trub1 rfc2 rfc2 tert tert LOC105024976 LOC105024976 ENSELUP00000016298 ENSELUP00000016298 ENSELUP00000017019 ENSELUP00000017019 DNA2 DNA2 rpa2 rpa2 PPP6C PPP6C ANKRD52 ANKRD52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpa3Uncharacterized protein. (121 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (221 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
wrnWRN RecQ like helicase. (1484 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (125 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (507 aa)
lig1DNA ligase. (1069 aa)
ENSELUP00000031341DNA polymerase. (1412 aa)
nop10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (382 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
ankrd44Ankyrin repeat domain 44. (980 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (608 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
tinf2TERF1 (TRF1)-interacting nuclear factor 2. (590 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (589 aa)
LOC105026040Cyclin A2; Belongs to the cyclin family. (435 aa)
wrap53WD repeat containing, antisense to TP53. (554 aa)
dscc1DNA replication and sister chromatid cohesion 1. (394 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
exd2Exonuclease 3'-5' domain containing 2. (660 aa)
recql4RecQ helicase-like 4. (1558 aa)
nhp2NHP2 ribonucleoprotein homolog (yeast). (117 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (520 aa)
pold4Si:dkey-28b4.7. (109 aa)
ppp6cSerine/threonine-protein phosphatase. (319 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (682 aa)
blmBLM RecQ like helicase. (1473 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
ankrd66Ankyrin repeat domain 66. (186 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
LOC105012459ANK_REP_REGION domain-containing protein. (1100 aa)
LOC105022303Ankyrin repeat domain 52a. (1080 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1198 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
rfc5AAA domain-containing protein. (335 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (381 aa)
pot1Protection of telomeres 1 homolog. (802 aa)
ankrd28Ankyrin repeat domain 28b. (1055 aa)
ten1TEN1 subunit of CST complex. (145 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (405 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
LOC105016238Uncharacterized protein. (610 aa)
pold1DNA polymerase. (1105 aa)
Trub1TruB pseudouridine (psi) synthase family member 1. (286 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1129 aa)
LOC105024976Zgc:110269. (350 aa)
ENSELUP00000016298Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
ENSELUP00000017019CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (806 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
rpa2Replication protein A2. (299 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
ANKRD52Ankyrin repeat domain 52. (1066 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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