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dnal4 dnal4 LOC105017014 LOC105017014 LOC105021344 LOC105021344 LOC105007426 LOC105007426 ENSELUP00000021764 ENSELUP00000021764 LOC105026695 LOC105026695 ENSELUP00000022114 ENSELUP00000022114 LOC105025851 LOC105025851 LOC105026862 LOC105026862 LOC105021137 LOC105021137 LOC105011288 LOC105011288 ENSELUP00000023022 ENSELUP00000023022 nab2 nab2 LOC105028395 LOC105028395 LOC105026079 LOC105026079 LOC105012148 LOC105012148 kras kras ENSELUP00000027385 ENSELUP00000027385 mapk7 mapk7 irs2 irs2 elk1 elk1 LOC105025131 LOC105025131 SGK1 SGK1 ENSELUP00000030454 ENSELUP00000030454 PPP2CB PPP2CB LOC105020581 LOC105020581 LOC105010673 LOC105010673 LOC105024111 LOC105024111 ENSELUP00000032954 ENSELUP00000032954 LOC105023895 LOC105023895 vrk3 vrk3 Mapk1 Mapk1 ap2b1 ap2b1 LOC105005693 LOC105005693 ENSELUP00000034426 ENSELUP00000034426 LOC105029514 LOC105029514 ap2s1 ap2s1 pik3cb pik3cb LOC105006541 LOC105006541 LOC105016684 LOC105016684 LOC105013553 LOC105013553 LOC105011486 LOC105011486 LOC105020978 LOC105020978 LOC105029132 LOC105029132 ENSELUP00000037185 ENSELUP00000037185 CSDE1 CSDE1 egr1 egr1 rps6ka1 rps6ka1 LOC105013205 LOC105013205 trib2 trib2 LOC105029053 LOC105029053 id2 id2 ENSELUP00000012597 ENSELUP00000012597 JUND JUND LOC105023872 LOC105023872 dusp6 dusp6 frs2 frs2 crkl crkl ENSELUP00000010466 ENSELUP00000010466 pik3ca pik3ca ENSELUP00000009067 ENSELUP00000009067 LOC105008548 LOC105008548 SHC3 SHC3 ralb ralb CREM-2 CREM-2 dusp3 dusp3 ENSELUP00000006444 ENSELUP00000006444 mapk15 mapk15 LOC105009026 LOC105009026 ppp4r4 ppp4r4 LOC105029770 LOC105029770 LOC105017320 LOC105017320 creb1 creb1 LOC105029098 LOC105029098 HRAS HRAS LOC105020226 LOC105020226 ENSELUP00000002328 ENSELUP00000002328 CREM CREM ascl1 ascl1 ENSELUP00000001414 ENSELUP00000001414 LOC105029391 LOC105029391 CREB1 CREB1 LOC105014171 LOC105014171 ENSELUP00000000166 ENSELUP00000000166 LOC105012171 LOC105012171 PIK3CA PIK3CA LOC105007566 LOC105007566 LOC105012809 LOC105012809 LOC105028432 LOC105028432 LOC105005921 LOC105005921 ENSELUP00000040366 ENSELUP00000040366 LOC105030761 LOC105030761 clta clta ppp4r1 ppp4r1 LOC105011557 LOC105011557 ENSELUP00000038206 ENSELUP00000038206 egr3 egr3 shc2 shc2 rit1 rit1 rapgef1 rapgef1 nab1 nab1 LOC105006321 LOC105006321 ENSELUP00000017099 ENSELUP00000017099 ENSELUP00000017121 ENSELUP00000017121 egr2 egr2 RALB RALB LOC105021738 LOC105021738
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnal4Dynein light chain. (106 aa)
LOC105017014Activating transcription factor 1. (305 aa)
LOC105021344Non-specific serine/threonine protein kinase. (718 aa)
LOC105007426Mitogen-activated protein kinase. (364 aa)
ENSELUP00000021764JunD proto-oncogene, AP-1 transcription factor subunit. (303 aa)
LOC105026695Serine/threonine-protein phosphatase. (309 aa)
ENSELUP00000022114Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (424 aa)
LOC105025851Chromodomain helicase DNA binding protein 4a. (1825 aa)
LOC105026862Ribosomal protein S6 kinase. (790 aa)
LOC105021137MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (365 aa)
LOC105011288Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (553 aa)
ENSELUP00000023022NGF domain-containing protein; Belongs to the NGF-beta family. (328 aa)
nab2NGFI-A binding protein 2 (EGR1 binding protein 2). (497 aa)
LOC105028395Rap guanine nucleotide exchange factor (GEF) 1b. (1198 aa)
LOC105026079Serine/threonine-protein phosphatase. (309 aa)
LOC105012148BHLH domain-containing protein. (436 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ENSELUP00000027385Uncharacterized protein. (202 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1123 aa)
irs2Insulin receptor substrate 2b. (1099 aa)
elk1ETS transcription factor ELK1. (481 aa)
LOC105025131Uncharacterized protein. (206 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
ENSELUP00000030454SH3 domain containing GRB2 like 2b, endophilin A1. (324 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC105020581Mitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (399 aa)
LOC105010673Serum response factor b. (596 aa)
LOC105024111V-crk avian sarcoma virus CT10 oncogene homolog. (319 aa)
ENSELUP00000032954Dynein light chain. (117 aa)
LOC105023895Mitogen-activated protein kinase. (361 aa)
vrk3VRK serine/threonine kinase 3. (509 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (371 aa)
ap2b1AP complex subunit beta. (952 aa)
LOC105005693Kinase D-interacting substrate 220b. (1758 aa)
ENSELUP00000034426ANK_REP_REGION domain-containing protein. (1573 aa)
LOC105029514Fibroblast growth factor receptor substrate 2b. (546 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (146 aa)
pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC105006541Inhibitor of DNA binding 3. (118 aa)
LOC105016684WRNPLPNID domain-containing protein. (870 aa)
LOC105013553Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
LOC105011486Protein phosphatase 2, regulatory subunit A, beta b. (595 aa)
LOC105020978Uncharacterized protein. (357 aa)
LOC105029132Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
ENSELUP00000037185Ribosomal protein S6 kinase. (775 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (967 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (502 aa)
rps6ka1Ribosomal protein S6 kinase. (822 aa)
LOC105013205MAPK activated protein kinase 2b. (605 aa)
trib2Tribbles pseudokinase 2. (344 aa)
LOC105029053Zgc:55558. (187 aa)
id2DNA-binding protein inhibitor ID-2. (135 aa)
ENSELUP00000012597Inhibitor of DNA binding 2b. (133 aa)
JUNDBZIP domain-containing protein. (312 aa)
LOC105023872Mitogen-activated protein kinase. (359 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
frs2Fibroblast growth factor receptor substrate 2a. (620 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (304 aa)
ENSELUP00000010466JunB proto-oncogene, AP-1 transcription factor subunit b. (303 aa)
pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1075 aa)
ENSELUP00000009067RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1163 aa)
LOC105008548V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
SHC3SHC adaptor protein 3. (692 aa)
ralbUncharacterized protein. (208 aa)
CREM-2cAMP responsive element modulator a. (316 aa)
dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (215 aa)
ENSELUP00000006444Formin binding protein 4. (693 aa)
mapk15Mitogen-activated protein kinase. (666 aa)
LOC105009026Insulin receptor substrate 2a. (1099 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (885 aa)
LOC105029770AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (443 aa)
LOC105017320MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (409 aa)
creb1cAMP responsive element binding protein 1. (274 aa)
LOC105029098AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (986 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC105020226Mitogen-activated protein kinase. (361 aa)
ENSELUP00000002328Inhibitor of DNA binding 4. (254 aa)
CREMBZIP domain-containing protein. (110 aa)
ascl1Achaete-scute family bHLH transcription factor 1a. (194 aa)
ENSELUP00000001414Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (382 aa)
LOC105029391FOS-like antigen 1a. (355 aa)
CREB1cAMP responsive element binding protein 1. (323 aa)
LOC105014171Uncharacterized protein. (797 aa)
ENSELUP00000000166PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (241 aa)
LOC105012171JunB proto-oncogene, AP-1 transcription factor subunit a. (333 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC105007566Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (201 aa)
LOC105012809Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
LOC105028432Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (186 aa)
LOC105005921Uncharacterized protein. (321 aa)
ENSELUP00000040366Uncharacterized protein. (82 aa)
LOC105030761MADS-box domain-containing protein. (534 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (256 aa)
ppp4r1Protein phosphatase 4, regulatory subunit 1. (973 aa)
LOC105011557Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (401 aa)
ENSELUP00000038206Uncharacterized protein. (1826 aa)
egr3Early growth response 3. (420 aa)
shc2SHC (Src homology 2 domain containing) transforming protein 2. (694 aa)
rit1Ras-like without CAAX 1. (211 aa)
rapgef1Rap guanine nucleotide exchange factor (GEF) 1a. (1216 aa)
nab1NGFI-A binding protein 1. (501 aa)
LOC105006321Tribbles pseudokinase 1. (355 aa)
ENSELUP00000017099NCD1 domain-containing protein. (150 aa)
ENSELUP00000017121Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
egr2Early growth response 2b. (431 aa)
RALBRAS like proto-oncogene B. (203 aa)
LOC105021738Serine/threonine-protein phosphatase. (369 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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