24 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	LOC105026211	Ubiquitin-like domain-containing protein. (128 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ENSELUP00000030130	Replication factor C subunit 1. (1033 aa)
	LOC105028498	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
	LOC105019838	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
	LOC105006037	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	LOC105024444	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	meiob	Methionine sulfoxide reductase B1b. (471 aa)
	rpa2	Replication protein A2. (299 aa)
	ENSELUP00000018876	REV3 like, DNA directed polymerase zeta catalytic subunit. (2835 aa)
	mad2l2	HORMA domain-containing protein. (216 aa)
	rfc2	Replication factor C (activator 1) 2. (368 aa)
	polk	Polymerase (DNA directed) kappa. (913 aa)
	rfc4	Replication factor C (activator 1) 4. (376 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	LOC105013139	ATPase family AAA domain containing 5a. (1854 aa)
	kxd1	KxDL motif containing 1. (187 aa)
	rfc5	AAA domain-containing protein. (335 aa)
	ENSELUP00000003468	Ubiquitin-like domain-containing protein. (86 aa)
	rps27a	Ribosomal protein S27a. (177 aa)
	rpa3	Uncharacterized protein. (121 aa)
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (917 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSELUP00000003468	ENSELUP00000030130	ENSELUP00000003468	ENSELUP00000030130	Ubiquitin-like domain-containing protein.	Replication factor C subunit 1.	0.685
ENSELUP00000003468	LOC105013139	ENSELUP00000003468	ENSELUP00000007630	Ubiquitin-like domain-containing protein.	ATPase family AAA domain containing 5a.	0.427
ENSELUP00000003468	LOC105024444	ENSELUP00000003468	ENSELUP00000021935	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.974
ENSELUP00000003468	LOC105026211	ENSELUP00000003468	ENSELUP00000034480	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.974
ENSELUP00000003468	LOC105028498	ENSELUP00000003468	ENSELUP00000029262	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.552
ENSELUP00000003468	Rev1	ENSELUP00000003468	ENSELUP00000039837	Ubiquitin-like domain-containing protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.961
ENSELUP00000003468	kxd1	ENSELUP00000003468	ENSELUP00000003987	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.714
ENSELUP00000003468	mad2l2	ENSELUP00000003468	ENSELUP00000018030	Ubiquitin-like domain-containing protein.	HORMA domain-containing protein.	0.652
ENSELUP00000003468	pcna	ENSELUP00000003468	ENSELUP00000007729	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.959
ENSELUP00000003468	polk	ENSELUP00000003468	ENSELUP00000009628	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed) kappa.	0.743
ENSELUP00000003468	rfc2	ENSELUP00000003468	ENSELUP00000014257	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 2.	0.674
ENSELUP00000003468	rfc3	ENSELUP00000003468	ENSELUP00000030603	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 3.	0.675
ENSELUP00000003468	rfc4	ENSELUP00000003468	ENSELUP00000008564	Ubiquitin-like domain-containing protein.	Replication factor C (activator 1) 4.	0.674
ENSELUP00000003468	rfc5	ENSELUP00000003468	ENSELUP00000003484	Ubiquitin-like domain-containing protein.	AAA domain-containing protein.	0.674
ENSELUP00000003468	rpa1	ENSELUP00000003468	ENSELUP00000022084	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.552
ENSELUP00000003468	rpa2	ENSELUP00000003468	ENSELUP00000019092	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.629
ENSELUP00000003468	rpa3	ENSELUP00000003468	ENSELUP00000042114	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.653
ENSELUP00000003468	rps27a	ENSELUP00000003468	ENSELUP00000003281	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.995
ENSELUP00000018876	ENSELUP00000030130	ENSELUP00000018876	ENSELUP00000030130	REV3 like, DNA directed polymerase zeta catalytic subunit.	Replication factor C subunit 1.	0.804
ENSELUP00000018876	LOC105013139	ENSELUP00000018876	ENSELUP00000007630	REV3 like, DNA directed polymerase zeta catalytic subunit.	ATPase family AAA domain containing 5a.	0.804