STRINGSTRING
kxd1 kxd1 rpa3 rpa3 eme1 eme1 LOC105011230 LOC105011230 SPIDR SPIDR LOC105031589 LOC105031589 snn-2 snn-2 RCBTB1 RCBTB1 gen1 gen1 wrn wrn kat5 kat5 LOC105026211 LOC105026211 top3a top3a mus81 mus81 Eme2 Eme2 polh polh rfc3 rfc3 ENSELUP00000030130 ENSELUP00000030130 LOC105007983 LOC105007983 LOC105028498 LOC105028498 LOC105019838 LOC105019838 tdrd3 tdrd3 LOC105006037 LOC105006037 slx4 slx4 exd2 exd2 recql4 recql4 pole4 pole4 rpa1 rpa1 LOC105024444 LOC105024444 pold4 pold4 pole3 pole3 rad51d rad51d blm blm pold3 pold3 atm atm meiob meiob rpa2 rpa2 DNA2 DNA2 ankrd11 ankrd11 XRCC2 XRCC2 pole2 pole2 rfc2 rfc2 exo1 exo1 pold1 pold1 rad51c rad51c nbn nbn mre11 mre11 polk polk LOC105020774 LOC105020774 rfc4 rfc4 rad51b rad51b pcna pcna brca2 brca2 brca1 brca1 ankrd12 ankrd12 xrcc3 xrcc3 rfc5 rfc5 ENSELUP00000003468 ENSELUP00000003468 rad51 rad51 rps27a rps27a LOC105020245 LOC105020245 pold2 pold2 ENSELUP00000001840 ENSELUP00000001840 pole pole rmi1 rmi1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kxd1KxDL motif containing 1. (187 aa)
rpa3Uncharacterized protein. (121 aa)
eme1Essential meiotic structure-specific endonuclease 1. (590 aa)
LOC105011230RAD50 homolog, double strand break repair protein. (1314 aa)
SPIDRScaffold protein involved in DNA repair. (968 aa)
LOC105031589Retinoblastoma binding protein 8. (690 aa)
snn-2RecQ mediated genome instability 2. (159 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
gen1Uncharacterized protein. (1014 aa)
wrnWRN RecQ like helicase. (1484 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (655 aa)
LOC105026211Ubiquitin-like domain-containing protein. (128 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1033 aa)
mus81MUS81 structure-specific endonuclease subunit. (617 aa)
Eme2ERCC4 domain-containing protein. (331 aa)
polhPolymerase (DNA directed), eta. (779 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
LOC105007983ANK_REP_REGION domain-containing protein. (1554 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
tdrd3Tudor domain containing 3. (932 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1998 aa)
exd2Exonuclease 3'-5' domain containing 2. (660 aa)
recql4RecQ helicase-like 4. (1558 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC105024444Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
pold4Si:dkey-28b4.7. (109 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa)
blmBLM RecQ like helicase. (1473 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
atmNon-specific serine/threonine protein kinase. (3011 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
rpa2Replication protein A2. (299 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
ankrd11Ankyrin repeat domain 11. (2915 aa)
XRCC2X-ray repair cross complementing 2. (316 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
exo1Exonuclease 1. (801 aa)
pold1DNA polymerase. (1105 aa)
rad51cRAD51 paralog C. (359 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
polkPolymerase (DNA directed) kappa. (913 aa)
LOC105020774Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (266 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
rad51bRAD51 paralog B. (378 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
brca2BRCA2 DNA repair associated. (2826 aa)
brca1Uncharacterized protein. (1565 aa)
ankrd12Ankyrin repeat domain 12. (2110 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
rfc5AAA domain-containing protein. (335 aa)
ENSELUP00000003468Ubiquitin-like domain-containing protein. (86 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
rps27aRibosomal protein S27a. (177 aa)
LOC105020245RAD51 associated protein 1. (374 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
ENSELUP00000001840Checkpoint kinase 1. (382 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (573 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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