Your Input: | |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | polh | Polymerase (DNA directed), eta. (779 aa) |
| | Eme2 | ERCC4 domain-containing protein. (331 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (617 aa) |
| | LOC105029658 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSELUP00000032605 | Histone domain-containing protein; Belongs to the histone H2B family. (108 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1033 aa) |
| | LOC105026211 | Ubiquitin-like domain-containing protein. (128 aa) |
| | Abl1 | Tyrosine-protein kinase. (1101 aa) |
| | ENSELUP00000035819 | Uncharacterized protein; Belongs to the histone H2B family. (122 aa) |
| | rnf169 | Ring finger protein 169. (631 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (655 aa) |
| | Slf1 | ANK_REP_REGION domain-containing protein. (352 aa) |
| | ENSELUP00000037811 | BRCT domain-containing protein. (139 aa) |
| | wrn | WRN RecQ like helicase. (1484 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (553 aa) |
| | gen1 | Uncharacterized protein. (1014 aa) |
| | ENSELUP00000038519 | Polymerase (DNA directed), theta. (1575 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (367 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | snn-2 | RecQ mediated genome instability 2. (159 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | timeless | Timeless circadian clock. (1235 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa) |
| | LOC105031589 | Retinoblastoma binding protein 8. (690 aa) |
| | pwwp2a | PWWP domain containing 2A. (1026 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (968 aa) |
| | LOC105019623 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (311 aa) |
| | LOC105011230 | RAD50 homolog, double strand break repair protein. (1314 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (590 aa) |
| | rpa3 | Uncharacterized protein. (121 aa) |
| | LOC105022147 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (162 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (383 aa) |
| | ENSELUP00000000043 | Uncharacterized protein. (130 aa) |
| | ENSELUP00000000120 | Zgc:173585; Belongs to the histone H2B family. (120 aa) |
| | LOC114838787 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105005930 | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | ENSELUP00000001052 | Reverse transcriptase domain-containing protein. (451 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (573 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1856 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa) |
| | ENSELUP00000001840 | Checkpoint kinase 1. (382 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (478 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa) |
| | LOC105020245 | RAD51 associated protein 1. (374 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (691 aa) |
| | rps27a | Ribosomal protein S27a. (177 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | ENSELUP00000003468 | Ubiquitin-like domain-containing protein. (86 aa) |
| | rfc5 | AAA domain-containing protein. (335 aa) |
| | kxd1 | KxDL motif containing 1. (187 aa) |
| | mdc1 | Uncharacterized protein. (2136 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | LOC105006832 | Histone H2A; Belongs to the histone H2A family. (137 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (2110 aa) |
| | brca1 | Uncharacterized protein. (1565 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (699 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | brca2 | BRCA2 DNA repair associated. (2826 aa) |
| | sumo2 | Small ubiquitin like modifier 2b. (149 aa) |
| | sirt6 | Sirtuin 6. (395 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1493 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (405 aa) |
| | rad51b | RAD51 paralog B. (378 aa) |
| | rad1 | Cell cycle checkpoint protein RAD1. (280 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (376 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (94 aa) |
| | LOC105020774 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (266 aa) |
| | polk | Polymerase (DNA directed) kappa. (913 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa) |
| | ENSELUP00000010055 | Histone H2B; Belongs to the histone H2B family. (162 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa) |
| | ENSELUP00000010472 | Reverse transcriptase domain-containing protein. (451 aa) |
| | SUMO3-2 | Small ubiquitin-related modifier. (94 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (1224 aa) |
| | rad51c | RAD51 paralog C. (359 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | exo1 | Exonuclease 1. (801 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (368 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (260 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (413 aa) |
| | atrip | ATR interacting protein. (863 aa) |
| | LOC105024976 | Zgc:110269. (350 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (629 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (316 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (484 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2915 aa) |
| | sirt7 | Sirtuin 7. (390 aa) |
| | LOC105011558 | Protein inhibitor of activated STAT, 4a. (538 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1421 aa) |
| | rpa2 | Replication protein A2. (299 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (471 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3011 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa) |
| | blm | BLM RecQ like helicase. (1473 aa) |
| | rad51d | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (335 aa) |
| | lig3 | DNA ligase. (1020 aa) |
| | Tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (327 aa) |
| | LOC105013723 | Uncharacterized protein. (453 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa) |
| | pold4 | Si:dkey-28b4.7. (109 aa) |
| | LOC105024444 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa) |
| | LOC105024361 | Serine/threonine-protein phosphatase. (307 aa) |
| | recql4 | RecQ helicase-like 4. (1558 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (660 aa) |
| | cdca7 | Cell division cycle associated 7a. (419 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1998 aa) |
| | LOC105006037 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (440 aa) |
| | tdrd3 | Tudor domain containing 3. (932 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1355 aa) |
| | ENSELUP00000025488 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (404 aa) |
| | rad9a | RAD9 checkpoint clamp component A. (352 aa) |
| | rhno1 | Si:ch73-352p4.5. (303 aa) |
| | LOC105026040 | Cyclin A2; Belongs to the cyclin family. (435 aa) |
| | ENSELUP00000028319 | Uncharacterized protein. (150 aa) |
| | LOC105019838 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa) |
| | LOC105028498 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa) |
| | LOC105012271 | Small ubiquitin-related modifier. (96 aa) |
| | LOC105007983 | ANK_REP_REGION domain-containing protein. (1554 aa) |
| | ENSELUP00000030130 | Replication factor C subunit 1. (1033 aa) |
