STRINGSTRING
snn-2 snn-2 timeless timeless cdk2 cdk2 LOC105031589 LOC105031589 LOC105019623 LOC105019623 PPP4C PPP4C LOC105011230 LOC105011230 rpa3 rpa3 LOC105022147 LOC105022147 rad9b rad9b ENSELUP00000000043 ENSELUP00000000043 ENSELUP00000000120 ENSELUP00000000120 LOC114838787 LOC114838787 LOC105005930 LOC105005930 ENSELUP00000001052 ENSELUP00000001052 rmi1 rmi1 tp53bp1 tp53bp1 ppp4r2 ppp4r2 rfc5 rfc5 mdc1 mdc1 LOC105006832 LOC105006832 ankrd12 ankrd12 brca1 brca1 rad17 rad17 atr atr sumo2 sumo2 sirt6 sirt6 topbp1 topbp1 ccna1 ccna1 rad1 rad1 rfc4 rfc4 SUMO3 SUMO3 mre11 mre11 ENSELUP00000010055 ENSELUP00000010055 nbn nbn ENSELUP00000010472 ENSELUP00000010472 SUMO3-2 SUMO3-2 uimc1 uimc1 rnf8 rnf8 exo1 exo1 rfc2 rfc2 brcc3 brcc3 babam2 babam2 atrip atrip hus1 hus1 rnf168 rnf168 ankrd11 ankrd11 LOC105011558 LOC105011558 DNA2 DNA2 rpa2 rpa2 atm atm blm blm Tipin Tipin LOC105013723 LOC105013723 rpa1 rpa1 ube2v2 ube2v2 LOC105024361 LOC105024361 recql4 recql4 LOC105006037 LOC105006037 nsd2 nsd2 ENSELUP00000025488 ENSELUP00000025488 abraxas1 abraxas1 rad9a rad9a rhno1 rhno1 LOC105026040 LOC105026040 ENSELUP00000028319 ENSELUP00000028319 LOC105019838 LOC105019838 LOC105028498 LOC105028498 LOC105012271 LOC105012271 LOC105007983 LOC105007983 rfc3 rfc3 LOC105029658 LOC105029658 ENSELUP00000032605 ENSELUP00000032605 top3a top3a ENSELUP00000035819 ENSELUP00000035819 rnf169 rnf169 kat5 kat5 ENSELUP00000037811 ENSELUP00000037811 wrn wrn babam1 babam1 RCBTB1 RCBTB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
snn-2RecQ mediated genome instability 2. (159 aa)
timelessTimeless circadian clock. (1235 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
LOC105031589Retinoblastoma binding protein 8. (690 aa)
LOC105019623Histone H2B; Belongs to the histone H2B family. (116 aa)
PPP4CSerine/threonine-protein phosphatase. (311 aa)
LOC105011230RAD50 homolog, double strand break repair protein. (1314 aa)
rpa3Uncharacterized protein. (121 aa)
LOC105022147UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
rad9bRAD9 checkpoint clamp component B. (383 aa)
ENSELUP00000000043Uncharacterized protein. (130 aa)
ENSELUP00000000120Zgc:173585; Belongs to the histone H2B family. (120 aa)
LOC114838787Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC105005930Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
ENSELUP00000001052Reverse transcriptase domain-containing protein. (451 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (573 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1856 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (478 aa)
rfc5AAA domain-containing protein. (335 aa)
mdc1Uncharacterized protein. (2136 aa)
LOC105006832Histone H2A; Belongs to the histone H2A family. (137 aa)
ankrd12Ankyrin repeat domain 12. (2110 aa)
brca1Uncharacterized protein. (1565 aa)
rad17RAD17 checkpoint clamp loader component. (699 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa)
sumo2Small ubiquitin like modifier 2b. (149 aa)
sirt6Sirtuin 6. (395 aa)
topbp1DNA topoisomerase II binding protein 1. (1493 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (405 aa)
rad1Cell cycle checkpoint protein RAD1. (280 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
SUMO3Small ubiquitin-related modifier. (94 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa)
ENSELUP00000010055Histone H2B; Belongs to the histone H2B family. (162 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa)
ENSELUP00000010472Reverse transcriptase domain-containing protein. (451 aa)
SUMO3-2Small ubiquitin-related modifier. (94 aa)
uimc1RAP80_UIM domain-containing protein. (1224 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa)
exo1Exonuclease 1. (801 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
babam2BRISC and BRCA1 A complex member 2. (413 aa)
atripATR interacting protein. (863 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (283 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (484 aa)
ankrd11Ankyrin repeat domain 11. (2915 aa)
LOC105011558Protein inhibitor of activated STAT, 4a. (538 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
rpa2Replication protein A2. (299 aa)
atmNon-specific serine/threonine protein kinase. (3011 aa)
blmBLM RecQ like helicase. (1473 aa)
TipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (327 aa)
LOC105013723Uncharacterized protein. (453 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa)
LOC105024361Serine/threonine-protein phosphatase. (307 aa)
recql4RecQ helicase-like 4. (1558 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1355 aa)
ENSELUP00000025488Histone H2A; Belongs to the histone H2A family. (128 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (404 aa)
rad9aRAD9 checkpoint clamp component A. (352 aa)
rhno1Si:ch73-352p4.5. (303 aa)
LOC105026040Cyclin A2; Belongs to the cyclin family. (435 aa)
ENSELUP00000028319Uncharacterized protein. (150 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
LOC105012271Small ubiquitin-related modifier. (96 aa)
LOC105007983ANK_REP_REGION domain-containing protein. (1554 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC105029658UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSELUP00000032605Histone domain-containing protein; Belongs to the histone H2B family. (108 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1033 aa)
ENSELUP00000035819Uncharacterized protein; Belongs to the histone H2B family. (122 aa)
rnf169Ring finger protein 169. (631 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (655 aa)
ENSELUP00000037811BRCT domain-containing protein. (139 aa)
wrnWRN RecQ like helicase. (1484 aa)
babam1BRISC and BRCA1 A complex member 1. (367 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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