82 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rbx1	Zf-rbx1 domain-containing protein. (135 aa)
	ENSELUP00000030130	Replication factor C subunit 1. (1033 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1498 aa)
	LOC105028498	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
	POLR2E	Uncharacterized protein. (210 aa)
	hmgn5	High mobility group nucleosome binding domain 6. (98 aa)
	LOC105019838	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
	LOC105029954	Pre-mRNA processing factor 19. (475 aa)
	LOC105008219	Transcription elongation factor A (SII), 3. (792 aa)
	ercc3	Excision repair cross-complementation group 3. (785 aa)
	ercc8	Excision repair cross-complementation group 8. (400 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (760 aa)
	ddb1	Damage-specific DNA binding protein 1. (1139 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1123 aa)
	LOC105006037	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa)
	TCEANC	Transcription elongation factor A N-terminal and central domain containing. (319 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	LOC105024444	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	pold4	Si:dkey-28b4.7. (109 aa)
	prpf19	Uncharacterized protein. (504 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (858 aa)
	LOC105025106	E1A binding protein p300 a. (2761 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa)
	lig3	DNA ligase. (1020 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
	meiob	Methionine sulfoxide reductase B1b. (471 aa)
	rpa2	Replication protein A2. (299 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	ENSELUP00000016997	Uncharacterized protein. (124 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (629 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (304 aa)
	ENSELUP00000014716	Uncharacterized protein. (91 aa)
	tceanc2	Transcription elongation factor A (SII) N-terminal and central domain containing 2. (235 aa)
	rfc2	Replication factor C (activator 1) 2. (368 aa)
	Polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1892 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1108 aa)
	pold1	DNA polymerase. (1105 aa)
	uvssa	UV-stimulated scaffold protein A. (738 aa)
	ENSELUP00000012634	RNA_pol_L_2 domain-containing protein. (75 aa)
	xab2	XPA binding protein 2. (980 aa)
	polk	Polymerase (DNA directed) kappa. (913 aa)
	ercc6	Excision repair cross-complementation group 6. (1494 aa)
	polr2l	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	rfc4	Replication factor C (activator 1) 4. (376 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	polr2f	DNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
	LOC105013139	ATPase family AAA domain containing 5a. (1854 aa)
	gtf2h2c	General transcription factor IIH subunit. (391 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	nrde2	NRDE-2, necessary for RNA interference, domain containing. (1174 aa)
	polr2d	DNA-directed RNA polymerase II subunit RPB4. (143 aa)
	LOC105008829	Si:ch73-1a9.3. (83 aa)
	kxd1	KxDL motif containing 1. (187 aa)
	rfc5	AAA domain-containing protein. (335 aa)
	ENSELUP00000003468	Ubiquitin-like domain-containing protein. (86 aa)
	rps27a	Ribosomal protein S27a. (177 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
	polr2g	DNA-directed RNA polymerase II subunit RPB7. (172 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (302 aa)
	rpa3	Uncharacterized protein. (121 aa)
	polr2e	DNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	tcea2	Transcription elongation factor A (SII), 2. (306 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (461 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (323 aa)
	isy1	ISY1 splicing factor homolog. (288 aa)
	LOC105026211	Ubiquitin-like domain-containing protein. (128 aa)
	phf3	PHD finger protein 3. (1703 aa)
	polr2j	DNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
	lig1	DNA ligase. (1069 aa)
	polr2c	DNA-directed RNA polymerase II subunit RPB3. (275 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
	usp40	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1238 aa)
	tcea1	Transcription elongation factor A (SII), 1. (292 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSELUP00000003468	ENSELUP00000012634	ENSELUP00000003468	ENSELUP00000012634	Ubiquitin-like domain-containing protein.	RNA_pol_L_2 domain-containing protein.	0.634
ENSELUP00000003468	ENSELUP00000014716	ENSELUP00000003468	ENSELUP00000014716	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.664
ENSELUP00000003468	ENSELUP00000016997	ENSELUP00000003468	ENSELUP00000016997	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.664
ENSELUP00000003468	ENSELUP00000030130	ENSELUP00000003468	ENSELUP00000030130	Ubiquitin-like domain-containing protein.	Replication factor C subunit 1.	0.685
ENSELUP00000003468	LOC105013139	ENSELUP00000003468	ENSELUP00000007630	Ubiquitin-like domain-containing protein.	ATPase family AAA domain containing 5a.	0.427
ENSELUP00000003468	LOC105024444	ENSELUP00000003468	ENSELUP00000021935	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.974
ENSELUP00000003468	LOC105025106	ENSELUP00000003468	ENSELUP00000020950	Ubiquitin-like domain-containing protein.	E1A binding protein p300 a.	0.591
ENSELUP00000003468	LOC105026211	ENSELUP00000003468	ENSELUP00000034480	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.974
ENSELUP00000003468	LOC105028498	ENSELUP00000003468	ENSELUP00000029262	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.552
ENSELUP00000003468	POLR2E	ENSELUP00000003468	ENSELUP00000028974	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.634
ENSELUP00000003468	Polr2a	ENSELUP00000003468	ENSELUP00000014179	Ubiquitin-like domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.664
ENSELUP00000003468	ccnh	ENSELUP00000003468	ENSELUP00000037068	Ubiquitin-like domain-containing protein.	Cyclin H; Belongs to the cyclin family.	0.670
ENSELUP00000003468	cdk7	ENSELUP00000003468	ENSELUP00000032902	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.602
ENSELUP00000003468	cul4a	ENSELUP00000003468	ENSELUP00000025791	Ubiquitin-like domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.723
ENSELUP00000003468	cul4b	ENSELUP00000003468	ENSELUP00000021011	Ubiquitin-like domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.723
ENSELUP00000003468	ddb1	ENSELUP00000003468	ENSELUP00000025124	Ubiquitin-like domain-containing protein.	Damage-specific DNA binding protein 1.	0.758
ENSELUP00000003468	ercc2	ENSELUP00000003468	ENSELUP00000038196	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 2.	0.678
ENSELUP00000003468	ercc3	ENSELUP00000003468	ENSELUP00000026946	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 3.	0.719
ENSELUP00000003468	ercc6	ENSELUP00000003468	ENSELUP00000009392	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 6.	0.903
ENSELUP00000003468	ercc8	ENSELUP00000003468	ENSELUP00000026346	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 8.	0.666