STRINGSTRING
pcna pcna prim1 prim1 lig1 lig1 ENSELUP00000031341 ENSELUP00000031341 rfc3 rfc3 ENSELUP00000030130 ENSELUP00000030130 LOC105028498 LOC105028498 pola2 pola2 LOC105019838 LOC105019838 LOC105006037 LOC105006037 rpa1 rpa1 prim2 prim2 pold4 pold4 pold3 pold3 meiob meiob rpa2 rpa2 DNA2 DNA2 LOC105024976 LOC105024976 rfc2 rfc2 pold1 pold1 rfc4 rfc4 RCBTB1 RCBTB1 LOC105013139 LOC105013139 rfc5 rfc5 pold2 pold2 rpa3 rpa3 fen1 fen1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
lig1DNA ligase. (1069 aa)
ENSELUP00000031341DNA polymerase. (1412 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (608 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (520 aa)
pold4Si:dkey-28b4.7. (109 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
rpa2Replication protein A2. (299 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
LOC105024976Zgc:110269. (350 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
pold1DNA polymerase. (1105 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC105013139ATPase family AAA domain containing 5a. (1854 aa)
rfc5AAA domain-containing protein. (335 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
rpa3Uncharacterized protein. (121 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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