Your Input: | |
| | ENSELUP00000000043 | Uncharacterized protein. (130 aa) |
| | ENSELUP00000000120 | Zgc:173585; Belongs to the histone H2B family. (120 aa) |
| | LOC114838787 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105005930 | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | ENSELUP00000001052 | Reverse transcriptase domain-containing protein. (451 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (573 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1856 aa) |
| | ENSELUP00000001840 | Checkpoint kinase 1. (382 aa) |
| | chek2 | Checkpoint kinase 2. (513 aa) |
| | rfc5 | AAA domain-containing protein. (335 aa) |
| | cdk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | mdc1 | Uncharacterized protein. (2136 aa) |
| | LOC105006832 | Histone H2A; Belongs to the histone H2A family. (137 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (2110 aa) |
| | brca1 | Uncharacterized protein. (1565 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (699 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1493 aa) |
| | rad1 | Cell cycle checkpoint protein RAD1. (280 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (376 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (702 aa) |
| | ENSELUP00000010055 | Histone H2B; Belongs to the histone H2B family. (162 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (814 aa) |
| | ywhae | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa) |
| | ENSELUP00000010472 | Reverse transcriptase domain-containing protein. (451 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (1224 aa) |
| | ccnb1 | Cyclin B1; Belongs to the cyclin family. (403 aa) |
| | LOC105016074 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (247 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa) |
| | exo1 | Exonuclease 1. (801 aa) |
| | LOC105017807 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (272 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (368 aa) |
| | ENSELUP00000014319 | Uncharacterized protein. (346 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (260 aa) |
| | LOC105006556 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (254 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a; Belongs to the 14-3-3 family. (244 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (413 aa) |
| | atrip | ATR interacting protein. (863 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (283 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (484 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2915 aa) |
| | LOC105011558 | Protein inhibitor of activated STAT, 4a. (538 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1421 aa) |
| | rpa2 | Replication protein A2. (299 aa) |
| | LOC105014973 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (471 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3011 aa) |
| | blm | BLM RecQ like helicase. (1473 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | ube2v2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa) |
| | recql4 | RecQ helicase-like 4. (1558 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (660 aa) |
| | LOC105025792 | 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa) |
| | cdca7 | Cell division cycle associated 7a. (419 aa) |
| | tdrd3 | Tudor domain containing 3. (932 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1355 aa) |
| | ENSELUP00000025488 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (404 aa) |
| | rad9a | RAD9 checkpoint clamp component A. (352 aa) |
| | LOC105008384 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa) |
| | LOC105008589 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa) |
| | cdc25b | Rhodanese domain-containing protein. (594 aa) |
| | rhno1 | Si:ch73-352p4.5. (303 aa) |
| | ENSELUP00000027421 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like; Belongs to the 14-3-3 family. (268 aa) |
| | LOC105018641 | Wee1-like protein kinase. (628 aa) |
| | ENSELUP00000028319 | Uncharacterized protein. (150 aa) |
| | LOC105028498 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa) |
| | LOC105007983 | ANK_REP_REGION domain-containing protein. (1554 aa) |
| | WEE1 | Wee1-like protein kinase. (610 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | ENSELUP00000032605 | Histone domain-containing protein; Belongs to the histone H2B family. (108 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1033 aa) |
| | ENSELUP00000035819 | Uncharacterized protein; Belongs to the histone H2B family. (122 aa) |
| | rnf169 | Ring finger protein 169. (631 aa) |
| | ENSELUP00000037276 | CYCLIN domain-containing protein; Belongs to the cyclin family. (230 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (655 aa) |
| | Slf1 | ANK_REP_REGION domain-containing protein. (352 aa) |
| | ENSELUP00000037811 | BRCT domain-containing protein. (139 aa) |
| | wrn | WRN RecQ like helicase. (1484 aa) |
| | LOC105005922 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | LOC105018118 | Wee1-like protein kinase. (546 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (367 aa) |
| | LOC105027777 | 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa) |
| | snn-2 | RecQ mediated genome instability 2. (159 aa) |
| | LOC105031589 | Retinoblastoma binding protein 8. (690 aa) |
| | LOC105019623 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | LOC105011230 | RAD50 homolog, double strand break repair protein. (1314 aa) |
| | rpa3 | Uncharacterized protein. (121 aa) |
| | LOC105022147 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (162 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (383 aa) |
