STRINGSTRING
meiob meiob neil1 neil1 tdg tdg pole pole pole3 pole3 lig3 lig3 rpa2 rpa2 parp1 parp1 nthl1 nthl1 rec114 rec114 xrcc1 xrcc1 pole2 pole2 LOC105024976 LOC105024976 ENSELUP00000015817 ENSELUP00000015817 rfc2 rfc2 rfc5 rfc5 adprhl2 adprhl2 ogg1 ogg1 rpa3 rpa3 pold3 pold3 apex1 apex1 apex2 apex2 rpa1 rpa1 pold4 pold4 lig1 lig1 pold1 pold1 ung ung vwa5b2 vwa5b2 rfc4 rfc4 pnkp pnkp pcna pcna LOC105013139 LOC105013139 ENSELUP00000031865 ENSELUP00000031865 polb polb rfc3 rfc3 ENSELUP00000030130 ENSELUP00000030130 fen1 fen1 smug1 smug1 RCBTB1 RCBTB1 mbd4 mbd4 parp3 parp3 MUTYH MUTYH PARG PARG LOC105028498 LOC105028498 LOC105019838 LOC105019838 LOC105009541 LOC105009541 LOC105015305 LOC105015305 LOC105006037 LOC105006037 pole4 pole4 parp2 parp2 mpg mpg pold2 pold2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
meiobMethionine sulfoxide reductase B1b. (471 aa)
neil1Nei-like DNA glycosylase 1. (399 aa)
tdgThymine DNA glycosylase, tandem duplicate 1. (479 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa)
lig3DNA ligase. (1020 aa)
rpa2Replication protein A2. (299 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (439 aa)
rec114REC114 meiotic recombination protein. (228 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (629 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC105024976Zgc:110269. (350 aa)
ENSELUP00000015817annotation not available (117 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
rfc5AAA domain-containing protein. (335 aa)
adprhl2ADP-ribosylhydrolase like 2. (378 aa)
ogg18-oxoguanine DNA glycosylase. (407 aa)
rpa3Uncharacterized protein. (121 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (312 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (582 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
pold4Si:dkey-28b4.7. (109 aa)
lig1DNA ligase. (1069 aa)
pold1DNA polymerase. (1105 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (303 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1422 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (612 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC105013139ATPase family AAA domain containing 5a. (1854 aa)
ENSELUP00000031865Si:cabz01080528.1. (762 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSELUP00000030130Replication factor C subunit 1. (1033 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
smug1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (337 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
mbd4MBD domain-containing protein. (589 aa)
parp3Poly [ADP-ribose] polymerase. (553 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (522 aa)
PARGPoly(ADP-ribose) glycohydrolase. (798 aa)
LOC105028498Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (505 aa)
LOC105019838Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (583 aa)
LOC105009541Thymine DNA glycosylase, tandem duplicate 2. (440 aa)
LOC105015305Poly (ADP-ribose) glycohydrolase, like. (621 aa)
LOC105006037Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (520 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa)
parp2Poly [ADP-ribose] polymerase. (691 aa)
mpgN-methylpurine DNA glycosylase. (276 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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