STRINGSTRING
pole pole pold2 pold2 rfc5 rfc5 mcm6 mcm6 rnaseh2c rnaseh2c pcna pcna rnaseh1 rnaseh1 pold1 pold1 rfc2 rfc2 LOC105024246 LOC105024246 pole2 pole2 ssbp1 ssbp1 DNA2 DNA2 rpa2 rpa2 mcm2 mcm2 pold3 pold3 pole3 pole3 pold4 pold4 prim2 prim2 rpa1 rpa1 pole4 pole4 LOC105026399 LOC105026399 pola2 pola2 rfc3 rfc3 mcm3 mcm3 mcm5 mcm5 lig1 lig1 rnaseh2b rnaseh2b fen1 fen1 mcm4 mcm4 Rnaseh2a Rnaseh2a rpa3 rpa3 mcm7 mcm7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1982 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
rfc5AAA domain-containing protein. (335 aa)
mcm6DNA helicase; Belongs to the MCM family. (821 aa)
rnaseh2cRibonuclease H2 subunit C. (135 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rnaseh1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (298 aa)
pold1DNA polymerase. (1105 aa)
rfc2Replication factor C (activator 1) 2. (368 aa)
LOC105024246DNA helicase; Belongs to the MCM family. (823 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
ssbp1Uncharacterized protein. (167 aa)
DNA2DNA replication helicase/nuclease 2. (1421 aa)
rpa2Replication protein A2. (299 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (151 aa)
pold4Si:dkey-28b4.7. (109 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (520 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (165 aa)
LOC105026399DNA helicase; Belongs to the MCM family. (813 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (608 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
mcm3DNA helicase; Belongs to the MCM family. (812 aa)
mcm5DNA helicase; Belongs to the MCM family. (739 aa)
lig1DNA ligase. (1069 aa)
rnaseh2bRibonuclease H2, subunit B. (307 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
mcm4DNA helicase; Belongs to the MCM family. (858 aa)
Rnaseh2aRibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (359 aa)
rpa3Uncharacterized protein. (121 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (730 aa)
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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