20 items (Esox lucius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (962 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (473 aa)
	rfc5	AAA domain-containing protein. (335 aa)
	mlh3	MutL homolog 3 (E. coli). (1272 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1387 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (715 aa)
	pold1	DNA polymerase. (1105 aa)
	exo1	Exonuclease 1. (801 aa)
	rfc2	Replication factor C (activator 1) 2. (368 aa)
	ssbp1	Uncharacterized protein. (167 aa)
	rpa2	Replication protein A2. (299 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (450 aa)
	pold4	Si:dkey-28b4.7. (109 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	Msh3	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (931 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	lig1	DNA ligase. (1069 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (918 aa)
	rpa3	Uncharacterized protein. (121 aa)

Your Current Organism:

Esox lucius

NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Msh3	exo1	ENSELUP00000025306	ENSELUP00000013695	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Exonuclease 1.	0.858
Msh3	lig1	ENSELUP00000025306	ENSELUP00000033781	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	DNA ligase.	0.642
Msh3	mlh1	ENSELUP00000025306	ENSELUP00000011736	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.972
Msh3	mlh3	ENSELUP00000025306	ENSELUP00000006541	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	MutL homolog 3 (E. coli).	0.936
Msh3	msh2	ENSELUP00000025306	ENSELUP00000001292	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
Msh3	msh6	ENSELUP00000025306	ENSELUP00000009868	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.970
Msh3	pcna	ENSELUP00000025306	ENSELUP00000007729	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.974
Msh3	pms2	ENSELUP00000025306	ENSELUP00000038090	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	PMS1 homolog 2, mismatch repair system component.	0.953
Msh3	pold1	ENSELUP00000025306	ENSELUP00000013108	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	DNA polymerase.	0.705
Msh3	pold3	ENSELUP00000025306	ENSELUP00000019751	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Polymerase (DNA-directed), delta 3, accessory subunit.	0.464
Msh3	rpa1	ENSELUP00000025306	ENSELUP00000022084	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.677
Msh3	rpa2	ENSELUP00000025306	ENSELUP00000019092	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Replication protein A2.	0.522
Msh3	rpa3	ENSELUP00000025306	ENSELUP00000042114	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.525
exo1	Msh3	ENSELUP00000013695	ENSELUP00000025306	Exonuclease 1.	MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	0.858
exo1	lig1	ENSELUP00000013695	ENSELUP00000033781	Exonuclease 1.	DNA ligase.	0.906
exo1	mlh1	ENSELUP00000013695	ENSELUP00000011736	Exonuclease 1.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.990
exo1	mlh3	ENSELUP00000013695	ENSELUP00000006541	Exonuclease 1.	MutL homolog 3 (E. coli).	0.860
exo1	msh2	ENSELUP00000013695	ENSELUP00000001292	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.991
exo1	msh6	ENSELUP00000013695	ENSELUP00000009868	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.976
exo1	pcna	ENSELUP00000013695	ENSELUP00000007729	Exonuclease 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.975