(37 nodes) Regulation of beta-cell development, and Neuronal helix-loop-helix transcription factor network (Salmo salar)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nx22a	Homeobox protein Nkx-2.2a isoform X1. (268 aa)
	znf488	Zinc finger protein 488. (518 aa)
	ENSSSAP00000003710	Insulinoma-associated 1b. (378 aa)
	NEUROD2	Neurogenic differentiation factor. (359 aa)
	LOC106583554	Oligodendrocyte transcription factor 3-like. (256 aa)
	LOC106604546	Paired mesoderm homeobox protein 2B-like. (286 aa)
	ENSSSAP00000013942	Neurogenin 3. (224 aa)
	LOC106569743	Neurogenic differentiation factor 6-B-like. (444 aa)
	nkx6-1	Homeobox protein Nkx-6.1 isoform X2. (323 aa)
	lhx1	LIM/homeobox protein Lhx1 isoform X1. (402 aa)
	LOC106596673	Paired box protein Pax-6-like. (302 aa)
	PAX2	Paired box 2. (133 aa)
	ENSSSAP00000025660	Neurogenic differentiation factor 1-like. (288 aa)
	nkx2-2	Homeobox protein Nkx-2.2 isoform X2. (276 aa)
	LOC106599594	Pancreas transcription factor 1 subunit alpha-like. (269 aa)
	ENSSSAP00000042344	annotation not available (104 aa)
	NEUROD2-2	Neurogenic differentiation factor. (358 aa)
	LOC106579148	Neurogenic differentiation factor 2-like. (438 aa)
	LOC106579536	Class E basic helix-loop-helix protein 22-like. (250 aa)
	ENSSSAP00000052813	Neurogenin 3. (247 aa)
	NEUROG1	Neurogenin-1-like. (228 aa)
	insm1	Insulinoma-associated protein 1. (472 aa)
	LOC106612289	Neurogenin-1-like. (218 aa)
	LOC106610890	Oligodendrocyte transcription factor 3-like. (256 aa)
	LOC106569290	Pancreas transcription factor 1 subunit alpha. (269 aa)
	LOC106583971	PR domain zinc finger protein 13-like. (631 aa)
	LOC106566929	Transcription factor HES-5-like. (168 aa)
	bhlhe22	Class E basic helix-loop-helix protein 22. (234 aa)
	LOC106571299	Homeobox protein Nkx-2.2a-like. (259 aa)
	neurod6	Neurogenic differentiation factor 6. (448 aa)
	LOC106572333	Transcription factor HES-5-like. (170 aa)
	LOC106613513	Transcription factor HES-1-like. (278 aa)
	LOC106607678	Homeobox protein Nkx-2.2a-like. (264 aa)
	INSM1	Insulinoma-associated protein 1a-like. (470 aa)
	NEUROD1	Neurogenic differentiation factor 1-like. (287 aa)
	BHLHE22	Class E basic helix-loop-helix protein 22-like. (226 aa)
	LOC106590392	Class E basic helix-loop-helix protein 22-like. (250 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BHLHE22	INSM1	ENSSSAP00000113836	ENSSSAP00000105223	Class E basic helix-loop-helix protein 22-like.	Insulinoma-associated protein 1a-like.	0.627
BHLHE22	LOC106569290	ENSSSAP00000113836	ENSSSAP00000075548	Class E basic helix-loop-helix protein 22-like.	Pancreas transcription factor 1 subunit alpha.	0.611
BHLHE22	LOC106599594	ENSSSAP00000113836	ENSSSAP00000038718	Class E basic helix-loop-helix protein 22-like.	Pancreas transcription factor 1 subunit alpha-like.	0.611
BHLHE22	PAX2	ENSSSAP00000113836	ENSSSAP00000022373	Class E basic helix-loop-helix protein 22-like.	Paired box 2.	0.407
BHLHE22	insm1	ENSSSAP00000113836	ENSSSAP00000063563	Class E basic helix-loop-helix protein 22-like.	Insulinoma-associated protein 1.	0.627
BHLHE22	lhx1	ENSSSAP00000113836	ENSSSAP00000020430	Class E basic helix-loop-helix protein 22-like.	LIM/homeobox protein Lhx1 isoform X1.	0.491
ENSSSAP00000003710	ENSSSAP00000013942	ENSSSAP00000003710	ENSSSAP00000013942	Insulinoma-associated 1b.	Neurogenin 3.	0.559
ENSSSAP00000003710	ENSSSAP00000052813	ENSSSAP00000003710	ENSSSAP00000052813	Insulinoma-associated 1b.	Neurogenin 3.	0.559
ENSSSAP00000003710	LOC106604546	ENSSSAP00000003710	ENSSSAP00000008210	Insulinoma-associated 1b.	Paired mesoderm homeobox protein 2B-like.	0.428
ENSSSAP00000003710	LOC106612289	ENSSSAP00000003710	ENSSSAP00000065983	Insulinoma-associated 1b.	Neurogenin-1-like.	0.559
ENSSSAP00000003710	NEUROG1	ENSSSAP00000003710	ENSSSAP00000062610	Insulinoma-associated 1b.	Neurogenin-1-like.	0.559
ENSSSAP00000013942	ENSSSAP00000003710	ENSSSAP00000013942	ENSSSAP00000003710	Neurogenin 3.	Insulinoma-associated 1b.	0.559
ENSSSAP00000013942	ENSSSAP00000042344	ENSSSAP00000013942	ENSSSAP00000042344	Neurogenin 3.	annotation not available	0.400
ENSSSAP00000013942	INSM1	ENSSSAP00000013942	ENSSSAP00000105223	Neurogenin 3.	Insulinoma-associated protein 1a-like.	0.559
ENSSSAP00000013942	LOC106566929	ENSSSAP00000013942	ENSSSAP00000088038	Neurogenin 3.	Transcription factor HES-5-like.	0.461
ENSSSAP00000013942	LOC106571299	ENSSSAP00000013942	ENSSSAP00000088275	Neurogenin 3.	Homeobox protein Nkx-2.2a-like.	0.583
ENSSSAP00000013942	LOC106572333	ENSSSAP00000013942	ENSSSAP00000098212	Neurogenin 3.	Transcription factor HES-5-like.	0.461
ENSSSAP00000013942	LOC106596673	ENSSSAP00000013942	ENSSSAP00000021927	Neurogenin 3.	Paired box protein Pax-6-like.	0.400
ENSSSAP00000013942	LOC106607678	ENSSSAP00000013942	ENSSSAP00000105064	Neurogenin 3.	Homeobox protein Nkx-2.2a-like.	0.583
ENSSSAP00000013942	LOC106613513	ENSSSAP00000013942	ENSSSAP00000101336	Neurogenin 3.	Transcription factor HES-1-like.	0.450