STRINGSTRING
ENSSSAP00000063782 ENSSSAP00000063782 LOC106569128 LOC106569128 hmces hmces LOC106582890 LOC106582890 ENSSSAP00000118738 ENSSSAP00000118738 LOC106560381 LOC106560381 rad18 rad18 rnf138 rnf138 ENSSSAP00000115911 ENSSSAP00000115911 SSBP4 SSBP4 dhx9 dhx9 shoc1 shoc1 LOC106580420 LOC106580420 tsn tsn LOC106583719 LOC106583719 pola1 pola1 LOC106568724 LOC106568724 wdr48 wdr48 ENSSSAP00000111484 ENSSSAP00000111484 blm blm LOC106565748 LOC106565748 rad52 rad52 samhd1 samhd1 LOC106586766 LOC106586766 LOC106608117 LOC106608117 LOC106580963 LOC106580963 lrpprc lrpprc ercc1 ercc1 ssbp3 ssbp3 rad50 rad50 MCM10 MCM10 rad51b rad51b LOC106574508 LOC106574508 neil3 neil3 WDR48-2 WDR48-2 msh2 msh2 myef2 myef2 LOC106570310 LOC106570310 LOC106582498 LOC106582498 LOC106576077 LOC106576077 pot1 pot1 LOC106590210 LOC106590210 LOC106586424 LOC106586424 mcm4 mcm4 ENSSSAP00000090082 ENSSSAP00000090082 rpa3 rpa3 rexo4 rexo4 LOC106576017 LOC106576017 sprtn sprtn xpc xpc dhx36 dhx36 mms22l mms22l ENSSSAP00000079966 ENSSSAP00000079966 ENSSSAP00000076231 ENSSSAP00000076231 tdp1 tdp1 radx radx LOC106611474 LOC106611474 LOC106613785 LOC106613785 ENSSSAP00000070238 ENSSSAP00000070238 ENSSSAP00000069563 ENSSSAP00000069563 LOC106594784 LOC106594784 ENSSSAP00000066677 ENSSSAP00000066677 LOC106612273 LOC106612273 LOC106580462 LOC106580462 fbh1 fbh1 LOC106604162 LOC106604162 LOC106612933 LOC106612933 SMARCAL1 SMARCAL1 RECQL RECQL mcm3 mcm3 LOC106609216 LOC106609216 bivm bivm mcm10 mcm10 fubp3 fubp3 LOC106581684 LOC106581684 LOC106583347 LOC106583347 ENSSSAP00000053097 ENSSSAP00000053097 LOC106579274 LOC106579274 LOC106569474 LOC106569474 rfa1 rfa1 LOC106560872 LOC106560872 brca2 brca2 ENSSSAP00000047854 ENSSSAP00000047854 ENSSSAP00000046253 ENSSSAP00000046253 cdc45 cdc45 NABP2 NABP2 lonp1 lonp1 rad51 rad51 LOC106566971 LOC106566971 ighmbp2 ighmbp2 LOC106574018 LOC106574018 LOC106608315 LOC106608315 ercc4 ercc4 mcm2 mcm2 LOC106571378 LOC106571378 rad51d rad51d ten1 ten1 ENSSSAP00000035618 ENSSSAP00000035618 LOC106587004 LOC106587004 LOC106569286 LOC106569286 LOC106585065 LOC106585065 mc6zb mc6zb ENSSSAP00000034296 ENSSSAP00000034296 MCM5 MCM5 tdp2 tdp2 WDR48 WDR48 ENSSSAP00000027524 ENSSSAP00000027524 recql4 recql4 LOC106601363 LOC106601363 ENSSSAP00000025751 ENSSSAP00000025751 LOC106575791 LOC106575791 dmc1 dmc1 ENSSSAP00000023650 ENSSSAP00000023650 LOC106598470 LOC106598470 polr2h polr2h ENSSSAP00000021964 ENSSSAP00000021964 LOC106598101 LOC106598101 LOC106564697 LOC106564697 ENSSSAP00000019926 ENSSSAP00000019926 LOC106586901 LOC106586901 ssbp4 ssbp4 LOC106583181 LOC106583181 LOC106565779 LOC106565779 ENSSSAP00000016990 ENSSSAP00000016990 LOC106575916 LOC106575916 LOC106605815 LOC106605815 ercc5 ercc5 LOC106607055 LOC106607055 ENSSSAP00000012203 ENSSSAP00000012203 mcm8 mcm8 mcm7 mcm7 meiob meiob ENSSSAP00000010800 ENSSSAP00000010800 top1 top1 LOC106605790 LOC106605790 ENSSSAP00000008276 ENSSSAP00000008276 LOC106607888 LOC106607888 LOC106601646 LOC106601646 LOC100196681 LOC100196681 rtf1 rtf1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSSAP00000063782tyrosyl-DNA phosphodiesterase 2a. (398 aa)
LOC106569128DNA helicase; Belongs to the MCM family. (892 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (363 aa)
LOC106582890DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (746 aa)
ENSSSAP00000118738annotation not available (267 aa)
LOC106560381DNA helicase; Belongs to the MCM family. (808 aa)
rad18E3 ubiquitin-protein ligase RAD18 isoform X2. (501 aa)
rnf138E3 ubiquitin-protein ligase RNF138. (271 aa)
ENSSSAP00000115911annotation not available (260 aa)
SSBP4Single-stranded DNA-binding protein 3-like isoform X1. (429 aa)
dhx9ATP-dependent RNA helicase A isoform X1. (1329 aa)
shoc1Uncharacterized protein C9orf84 homolog. (1558 aa)
LOC106580420Single-stranded DNA-binding protein 2. (358 aa)
tsnTranslin. (235 aa)
LOC106583719DNA helicase; Belongs to the MCM family. (921 aa)
pola1DNA polymerase. (1466 aa)
LOC106568724RNA exonuclease 4-like. (491 aa)
wdr48WD repeat-containing protein 48 isoform X3. (706 aa)
ENSSSAP00000111484SET domain and mariner transposase fusion gene. (283 aa)
blmBloom syndrome protein isoform X1. (1471 aa)
LOC106565748Histone-lysine N-methyltransferase SETMAR-like. (304 aa)
rad52DNA repair protein RAD52 homolog. (448 aa)
samhd1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2. (713 aa)
LOC106586766CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (439 aa)
LOC106608117Uncharacterized protein LOC106608117. (1321 aa)
LOC106580963Structural maintenance of chromosomes protein. (1313 aa)
lrpprcLeucine-rich PPR motif-containing protein, mitochondrial. (1455 aa)
ercc1DNA excision repair protein ERCC-1. (383 aa)
ssbp3Single-stranded DNA-binding protein 3 isoform X1. (384 aa)
rad50DNA repair protein RAD50. (1316 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (706 aa)
rad51bDNA repair protein RAD51 homolog 2 isoform X1. (418 aa)
LOC106574508Single-stranded DNA-binding protein 3-like. (422 aa)
neil3Endonuclease 8-like 3. (589 aa)
WDR48-2WD repeat-containing protein 48-like isoform X3. (698 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (928 aa)
myef2Myelin expression factor 2-like isoform X1. (611 aa)
LOC106570310Replication protein A 14 kDa subunit-like. (147 aa)
LOC106582498Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (310 aa)
LOC106576077Single-stranded DNA-binding protein, mitochondrial-like isoform X1. (221 aa)
pot1Protection of telomeres protein 1 isoform X1. (838 aa)
LOC106590210DNA endonuclease RBBP8-like. (723 aa)
LOC106586424Translin-like isoform X1. (229 aa)
mcm4DNA helicase; Belongs to the MCM family. (881 aa)
ENSSSAP00000090082Minichromosome maintenance complex component 5. (441 aa)
rpa3Replication protein A3. (159 aa)
rexo4REX4, RNA exonuclease 4 homolog isoform X1. (444 aa)
LOC106576017ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (830 aa)
sprtnsprT-like domain-containing protein Spartan. (479 aa)
xpcDNA repair protein complementing XP-C cells. (905 aa)
dhx36ATP-dependent RNA helicase DHX36. (780 aa)
mms22lProtein MMS22-like isoform X1. (1314 aa)
ENSSSAP00000079966annotation not available (1325 aa)
ENSSSAP00000076231annotation not available (183 aa)
tdp1tyrosyl-DNA phosphodiesterase 1 isoform X1. (644 aa)
radxUncharacterized protein CXorf57 homolog isoform X1. (870 aa)
LOC106611474RNA polymerase-associated protein RTF1 homolog. (767 aa)
LOC106613785Single-stranded DNA-binding protein 3-like. (434 aa)
ENSSSAP00000070238annotation not available (108 aa)
ENSSSAP00000069563annotation not available (136 aa)
LOC106594784Structural maintenance of chromosomes protein 2-like. (112 aa)
ENSSSAP00000066677Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like. (422 aa)
LOC106612273DNA-directed RNA polymerase II subunit RPB7. (172 aa)
LOC106580462tyrosyl-DNA phosphodiesterase 2-like isoform X2. (580 aa)
fbh1F-box only protein 18 isoform X1. (1059 aa)
LOC106604162DNA-directed RNA polymerase II subunit RPB7-like. (178 aa)
LOC106612933Replication protein A 70 kDa DNA-binding subunit-like. (632 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1. (560 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (839 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
LOC106609216Single-stranded DNA-binding protein, mitochondrial-like. (196 aa)
bivmBasic immunoglobulin-like variable motif-containing protein isoform X1. (524 aa)
mcm10Protein MCM10 homolog isoform X1. (934 aa)
fubp3Far upstream element-binding protein 3 isoform X3. (605 aa)
LOC106581684SOSS complex subunit B2-like. (217 aa)
LOC106583347SOSS complex subunit B1-like. (193 aa)
ENSSSAP00000053097annotation not available (407 aa)
LOC106579274Twinkle protein, mitochondrial-like. (743 aa)
LOC106569474DNA helicase; Belongs to the MCM family. (837 aa)
rfa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC106560872DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (753 aa)
brca2Breast cancer type 2 susceptibility protein isoform X5. (2826 aa)
ENSSSAP00000047854annotation not available (265 aa)
ENSSSAP00000046253CDC45 cell division cycle 45 homolog (S. cerevisiae). (421 aa)
cdc45CDC45-related protein. (569 aa)
NABP2SOSS complex subunit B1-B-like isoform X1. (199 aa)
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1014 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
LOC106566971Far upstream element-binding protein 3-like isoform X8. (660 aa)
ighmbp2DNA-binding protein SMUBP-2. (1010 aa)
LOC106574018Single-stranded DNA-binding protein 3-like isoform X2. (379 aa)
LOC106608315Zygotic DNA replication licensing factor mcm3-like. (385 aa)
ercc4DNA repair endonuclease XPF. (911 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
LOC106571378DNA helicase MCM9-like; Belongs to the MCM family. (1213 aa)
rad51dDNA repair protein RAD51 homolog 4. (336 aa)
ten1CST complex subunit TEN1 isoform X2. (102 aa)
ENSSSAP00000035618annotation not available (575 aa)
LOC106587004Far upstream element-binding protein 3-like isoform X6. (595 aa)
LOC106569286DNA helicase; Belongs to the MCM family. (826 aa)
LOC106585065Single-stranded DNA-binding protein 2-like. (400 aa)
mc6zbDNA helicase; Belongs to the MCM family. (838 aa)
ENSSSAP00000034296annotation not available (126 aa)
MCM5DNA helicase; Belongs to the MCM family. (770 aa)
tdp2tyrosyl-DNA phosphodiesterase 2 isoform X1. (403 aa)
WDR48WD repeat-containing protein 48-like isoform X1. (714 aa)
ENSSSAP00000027524annotation not available (156 aa)
recql4ATP-dependent DNA helicase Q4. (1404 aa)
LOC106601363ATPase SWSAP1-like isoform X1. (126 aa)
ENSSSAP00000025751annotation not available (80 aa)
LOC106575791SOSS complex subunit B2-like. (203 aa)
dmc1Meiotic recombination protein DMC1/LIM15 homolog isoform X2; Belongs to the RecA family. (337 aa)
ENSSSAP00000023650annotation not available (83 aa)
LOC106598470Structural maintenance of chromosomes protein 2-like isoform X1. (180 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
ENSSSAP00000021964annotation not available (163 aa)
LOC106598101Structural maintenance of chromosomes protein 2-like. (160 aa)
LOC106564697CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
ENSSSAP00000019926annotation not available (202 aa)
LOC106586901Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (309 aa)
ssbp4Single-stranded DNA-binding protein 4 isoform X1. (429 aa)
LOC106583181E3 ubiquitin-protein ligase RAD18-like isoform X1. (584 aa)
LOC106565779DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (754 aa)
ENSSSAP00000016990annotation not available (257 aa)
LOC106575916DNA annealing helicase and endonuclease ZRANB3-like isoform X1. (523 aa)
LOC106605815DNA-directed RNA polymerase III subunit RPC3-like. (569 aa)
ercc5DNA repair protein complementing XP-G cells. (775 aa)
LOC106607055DNA replication licensing factor mcm5-like; Belongs to the MCM family. (525 aa)
ENSSSAP00000012203annotation not available (115 aa)
mcm8DNA helicase MCM8; Belongs to the MCM family. (862 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
meiobMeiosis-specific with OB domain-containing protein isoform X1. (464 aa)
ENSSSAP00000010800annotation not available (742 aa)
top1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (730 aa)
LOC106605790RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (585 aa)
ENSSSAP00000008276Structural maintenance of chromosomes protein 2-like. (163 aa)
LOC106607888DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
LOC106601646Uncharacterized protein C17orf53 homolog isoform X1. (502 aa)
LOC100196681Far upstream element-binding protein 3 isoform X2. (543 aa)
rtf1RNA polymerase-associated protein RTF1 homolog isoform X1. (694 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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