STRINGSTRING
LOC106587717 LOC106587717 LOC106612933 LOC106612933 LOC100194728 LOC100194728 ccne2 ccne2 fbh1 fbh1 ENSSSAP00000065044 ENSSSAP00000065044 ccne2-2 ccne2-2 ENSSSAP00000066677 ENSSSAP00000066677 MRE11 MRE11 LOC106579187 LOC106579187 rpain rpain LOC106595036 LOC106595036 dpoe4 dpoe4 ENSSSAP00000090923 ENSSSAP00000090923 mcm4 mcm4 LOC106611229 LOC106611229 ENSSSAP00000090082 ENSSSAP00000090082 rfc4 rfc4 LOC100195904 LOC100195904 ENSSSAP00000088520 ENSSSAP00000088520 LOC106576017 LOC106576017 pole pole rfc5 rfc5 gins1 gins1 DNA2 DNA2 mms22l mms22l pole3 pole3 ENSSSAP00000079200 ENSSSAP00000079200 LOC106587264 LOC106587264 LOC106612850 LOC106612850 ENSSSAP00000077560 ENSSSAP00000077560 prim1 prim1 LOC106571944 LOC106571944 LOC106590185 LOC106590185 orc6 orc6 ENSSSAP00000075319 ENSSSAP00000075319 timeless timeless LOC106569323 LOC106569323 ENSSSAP00000070238 ENSSSAP00000070238 DDX21 DDX21 polg polg ENSSSAP00000073570 ENSSSAP00000073570 atr atr Mre11 Mre11 sld5 sld5 ENSSSAP00000019926 ENSSSAP00000019926 gen1 gen1 LOC106591874 LOC106591874 orc3 orc3 poln poln recql4 recql4 ENSSSAP00000028441 ENSSSAP00000028441 ENSSSAP00000029663 ENSSSAP00000029663 ENSSSAP00000030396 ENSSSAP00000030396 LOC106571917 LOC106571917 blm blm mgme1 mgme1 ENSSSAP00000111484 ENSSSAP00000111484 pole2 pole2 pola1 pola1 ENSSSAP00000112721 ENSSSAP00000112721 LOC106583719 LOC106583719 ENSSSAP00000115415 ENSSSAP00000115415 wrnip1 wrnip1 LOC106560381 LOC106560381 lig1 lig1 LOC106582789 LOC106582789 ccd16 ccd16 LOC106569128 LOC106569128 samhd1 samhd1 LOC106565748 LOC106565748 LOC106602003 LOC106602003 ENSSSAP00000109661 ENSSSAP00000109661 LOC106564654 LOC106564654 ENSSSAP00000103411 ENSSSAP00000103411 MCM10 MCM10 wdhd1 wdhd1 pold2 pold2 gins3 gins3 ENSSSAP00000096806 ENSSSAP00000096806 ENSSSAP00000095920 ENSSSAP00000095920 LOC106578660 LOC106578660 LOC106562060 LOC106562060 ENSSSAP00000093833 ENSSSAP00000093833 ENSSSAP00000093095 ENSSSAP00000093095 LOC106570148 LOC106570148 exd2 exd2 eme1 eme1 LOC106600433 LOC106600433 LOC106591833 LOC106591833 rfc3 rfc3 LOC106601412 LOC106601412 ENSSSAP00000002832 ENSSSAP00000002832 prim2 prim2 LOC106604099 LOC106604099 pola2 pola2 ENSSSAP00000005368 ENSSSAP00000005368 LOC106607888 LOC106607888 tonsl tonsl LOC106606972 LOC106606972 ENSSSAP00000007214 ENSSSAP00000007214 pold4 pold4 LOC106567810 LOC106567810 pold3 pold3 ENSSSAP00000010800 ENSSSAP00000010800 mcm7 mcm7 LOC106607055 LOC106607055 gmnc gmnc rfc2 rfc2 LOC106579040 LOC106579040 orc5 orc5 LOC106613703 LOC106613703 MCM5 MCM5 LOC106601920 LOC106601920 primpol primpol LOC106564750 LOC106564750 mc6zb mc6zb LOC106569286 LOC106569286 LOC106612325 LOC106612325 LOC106606528 LOC106606528 ENSSSAP00000036217 ENSSSAP00000036217 LOC106575916 LOC106575916 donson donson mcm2 mcm2 wrn wrn LOC106565925 LOC106565925 Orc4 Orc4 tipin tipin LOC106608315 LOC106608315 LOC106603335 LOC106603335 ZNF830 ZNF830 rad51 rad51 ENSSSAP00000042990 ENSSSAP00000042990 ENSSSAP00000043443 ENSSSAP00000043443 orc1 orc1 mcmbp mcmbp ENSSSAP00000044108 ENSSSAP00000044108 LOC106570548 LOC106570548 cdc45 cdc45 DPOD1 DPOD1 ENSSSAP00000046253 ENSSSAP00000046253 LOC106567639 LOC106567639 brca2 brca2 LOC106613619 LOC106613619 PSF2 PSF2 orc4 orc4 rfa1 rfa1 LOC106569474 LOC106569474 LOC100380687 LOC100380687 LOC106579274 LOC106579274 ENSSSAP00000052068 ENSSSAP00000052068 ENSSSAP00000053571 ENSSSAP00000053571 gmnn gmnn mcm10 mcm10 lig3 lig3 mcm3 mcm3 RECQL RECQL SMARCAL1 SMARCAL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106587717Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (553 aa)
LOC106612933Replication protein A 70 kDa DNA-binding subunit-like. (632 aa)
LOC100194728Nucleolar RNA helicase 2 isoform X1. (776 aa)
ccne2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (395 aa)
fbh1F-box only protein 18 isoform X1. (1059 aa)
ENSSSAP00000065044Origin recognition complex, subunit 6. (145 aa)
ccne2-2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (420 aa)
ENSSSAP00000066677Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like. (422 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (474 aa)
LOC106579187Probable crossover junction endonuclease EME2. (256 aa)
rpainRPA-interacting protein A. (227 aa)
LOC106595036Helicase and polymerase-containing protein TEBICHI-like isoform X2. (137 aa)
dpoe4DNA-directed DNA polymerase epsilon 4. (130 aa)
ENSSSAP00000090923annotation not available (91 aa)
mcm4DNA helicase; Belongs to the MCM family. (881 aa)
LOC106611229Bromodomain adjacent to zinc finger domain protein 1A-like isoform X1. (1178 aa)
ENSSSAP00000090082Minichromosome maintenance complex component 5. (441 aa)
rfc4Replication factor C subunit 4 isoform X1. (361 aa)
LOC100195904Zinc finger protein ZPR1 isoform X1. (450 aa)
ENSSSAP00000088520Replication factor C (activator 1) 5. (305 aa)
LOC106576017ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (830 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
rfc5Replication factor C subunit 5. (341 aa)
gins1DNA replication complex GINS protein PSF1. (196 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1073 aa)
mms22lProtein MMS22-like isoform X1. (1314 aa)
pole3DNA-directed DNA polymerase epsilon 3. (151 aa)
ENSSSAP00000079200Replication factor C (activator 1) 2. (372 aa)
LOC106587264DNA replication factor Cdt1-like. (685 aa)
LOC106612850Geminin coiled-coil domain-containing protein 1-like. (426 aa)
ENSSSAP00000077560DEAD (Asp-Glu-Ala-Asp) box polypeptide 23. (294 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (476 aa)
LOC106571944Probable ATP-dependent RNA helicase DDX23. (815 aa)
LOC106590185DNA topoisomerase 2-binding protein 1-A-like. (1534 aa)
orc6Origin recognition complex subunit 6. (291 aa)
ENSSSAP00000075319annotation not available (299 aa)
timelessProtein timeless homolog. (1252 aa)
LOC106569323THO complex subunit 1-like isoform X1. (656 aa)
ENSSSAP00000070238annotation not available (108 aa)
DDX21Nucleolar RNA helicase 2-like. (745 aa)
polgDNA polymerase subunit gamma-1. (1202 aa)
ENSSSAP00000073570Origin recognition complex, subunit 5. (416 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2476 aa)
Mre11MRE11 homolog, double strand break repair nuclease. (452 aa)
sld5DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
ENSSSAP00000019926annotation not available (202 aa)
gen1Flap endonuclease GEN homolog 1. (979 aa)
LOC106591874Exonuclease 3'-5' domain-containing protein 2-like. (550 aa)
orc3Origin recognition complex subunit 3. (720 aa)
polnDNA polymerase nu. (1656 aa)
recql4ATP-dependent DNA helicase Q4. (1404 aa)
ENSSSAP00000028441annotation not available (109 aa)
ENSSSAP00000029663annotation not available (85 aa)
ENSSSAP00000030396annotation not available (221 aa)
LOC106571917NAD-dependent protein deacetylase sirtuin-7-like isoform X2. (406 aa)
blmBloom syndrome protein isoform X1. (1471 aa)
mgme1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family. (353 aa)
ENSSSAP00000111484SET domain and mariner transposase fusion gene. (283 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (567 aa)
pola1DNA polymerase. (1466 aa)
ENSSSAP00000112721annotation not available (332 aa)
LOC106583719DNA helicase; Belongs to the MCM family. (921 aa)
ENSSSAP00000115415annotation not available (257 aa)
wrnip1ATPase WRNIP1 isoform X1. (610 aa)
LOC106560381DNA helicase; Belongs to the MCM family. (808 aa)
lig1DNA ligase. (1088 aa)
LOC106582789E3 ubiquitin-protein ligase TRAIP-like. (261 aa)
ccd16Coiled-coil domain-containing protein 16. (352 aa)
LOC106569128DNA helicase; Belongs to the MCM family. (892 aa)
samhd1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2. (713 aa)
LOC106565748Histone-lysine N-methyltransferase SETMAR-like. (304 aa)
LOC106602003Bromodomain adjacent to zinc finger domain protein 1A-like isoform X2. (1299 aa)
ENSSSAP00000109661DNA primase subunit 2. (432 aa)
LOC106564654ATPase family AAA domain-containing protein 5-like isoform X2. (547 aa)
ENSSSAP00000103411annotation not available (112 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (706 aa)
wdhd1WD repeat and HMG-box DNA-binding protein 1 isoform X1. (1169 aa)
pold2DNA polymerase subunit delta-2. (500 aa)
gins3DNA replication complex GINS protein PSF3. (174 aa)
ENSSSAP00000096806GINS complex subunit 4 (Sld5 homolog). (216 aa)
ENSSSAP00000095920WD repeat domain 18. (351 aa)
LOC106578660DNA topoisomerase 2-binding protein 1-A-like isoform X1. (1446 aa)
LOC106562060DNA replication factor Cdt1-like. (687 aa)
ENSSSAP00000093833annotation not available (134 aa)
ENSSSAP00000093095annotation not available (250 aa)
LOC106570148Nurim-like. (275 aa)
exd2Exonuclease 3'-5' domain-containing protein 2. (421 aa)
eme1Crossover junction endonuclease EME1 isoform X1. (564 aa)
LOC106600433THO complex subunit 1-like. (679 aa)
LOC106591833NAD-dependent protein deacetylase sirtuin-7-like isoform X1. (406 aa)
rfc3Replication factor C subunit 3 isoform X1. (334 aa)
LOC106601412ATP-dependent DNA helicase Q5-like. (798 aa)
ENSSSAP00000002832annotation not available (282 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (515 aa)
LOC106604099Transcriptional regulator ATRX-like. (1206 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (617 aa)
ENSSSAP00000005368annotation not available (283 aa)
LOC106607888DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
tonslTonsoku-like protein. (1433 aa)
LOC106606972ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (443 aa)
ENSSSAP00000007214Origin recognition complex, subunit 3. (574 aa)
pold4DNA polymerase subunit delta-4. (125 aa)
LOC106567810Transcriptional regulator ATRX-like. (1697 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (449 aa)
ENSSSAP00000010800annotation not available (742 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
LOC106607055DNA replication licensing factor mcm5-like; Belongs to the MCM family. (525 aa)
gmncGeminin coiled-coil domain-containing protein 1. (428 aa)
rfc2Replication factor C subunit 2. (381 aa)
LOC106579040LOW QUALITY PROTEIN: nucleolar complex protein 3 homolog. (678 aa)
orc5Origin recognition complex subunit 5. (445 aa)
LOC106613703DNA polymerase epsilon subunit 4-like. (149 aa)
MCM5DNA helicase; Belongs to the MCM family. (770 aa)
LOC106601920DNA polymerase delta catalytic subunit-like. (681 aa)
primpolDNA-directed primase/polymerase protein. (528 aa)
LOC106564750Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
mc6zbDNA helicase; Belongs to the MCM family. (838 aa)
LOC106569286DNA helicase; Belongs to the MCM family. (826 aa)
LOC106612325Transcriptional regulator ATRX-like. (2621 aa)
LOC106606528ATPase family AAA domain-containing protein 5-like isoform X1. (1873 aa)
ENSSSAP00000036217annotation not available (352 aa)
LOC106575916DNA annealing helicase and endonuclease ZRANB3-like isoform X1. (523 aa)
donsonProtein downstream neighbor of Son. (605 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
wrnWerner syndrome ATP-dependent helicase isoform X2. (1467 aa)
LOC106565925E3 ubiquitin-protein ligase TRAIP-like. (347 aa)
Orc4Origin recognition complex subunit 4. (183 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa)
LOC106608315Zygotic DNA replication licensing factor mcm3-like. (385 aa)
LOC106603335Transcriptional regulator ATRX-like. (1643 aa)
ZNF830Zinc finger protein 830-like. (345 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
ENSSSAP00000042990annotation not available (1200 aa)
ENSSSAP00000043443annotation not available (148 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (883 aa)
mcmbpMini-chromosome maintenance complex-binding protein; Associated component of the mcm complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the mcm complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the mcm complex. Required for sister chromatid cohesion (By similarity). (634 aa)
ENSSSAP00000044108annotation not available (850 aa)
LOC106570548Geminin-like. (249 aa)
cdc45CDC45-related protein. (569 aa)
DPOD1DNA polymerase. (899 aa)
ENSSSAP00000046253CDC45 cell division cycle 45 homolog (S. cerevisiae). (421 aa)
LOC106567639Zinc finger protein ZPR1-like. (441 aa)
brca2Breast cancer type 2 susceptibility protein isoform X5. (2826 aa)
LOC106613619WD repeat-containing protein 18. (431 aa)
PSF2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (145 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (461 aa)
rfa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC106569474DNA helicase; Belongs to the MCM family. (837 aa)
LOC100380687E3 ubiquitin-protein ligase TRAIP. (393 aa)
LOC106579274Twinkle protein, mitochondrial-like. (743 aa)
ENSSSAP00000052068annotation not available (370 aa)
ENSSSAP00000053571GINS complex subunit 2. (124 aa)
gmnnGeminin isoform X1. (288 aa)
mcm10Protein MCM10 homolog isoform X1. (934 aa)
lig3DNA ligase. (1023 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (839 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1. (560 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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