40 items (Salmo salar) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM5	DNA helicase; Belongs to the MCM family. (770 aa)
	LOC106569128	DNA helicase; Belongs to the MCM family. (892 aa)
	LOC106560381	DNA helicase; Belongs to the MCM family. (808 aa)
	LOC106583719	DNA helicase; Belongs to the MCM family. (921 aa)
	blm	Bloom syndrome protein isoform X1. (1471 aa)
	sld5	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
	gins3	DNA replication complex GINS protein PSF3. (174 aa)
	ENSSSAP00000096806	GINS complex subunit 4 (Sld5 homolog). (216 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (881 aa)
	ENSSSAP00000090082	Minichromosome maintenance complex component 5. (441 aa)
	LOC106576017	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (830 aa)
	ENSSSAP00000070238	annotation not available (108 aa)
	LOC106612933	Replication protein A 70 kDa DNA-binding subunit-like. (632 aa)
	RECQL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (839 aa)
	mcm3	DNA helicase; Belongs to the MCM family. (813 aa)
	ENSSSAP00000053571	GINS complex subunit 2. (124 aa)
	LOC106579274	Twinkle protein, mitochondrial-like. (743 aa)
	LOC106569474	DNA helicase; Belongs to the MCM family. (837 aa)
	rfa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	PSF2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (145 aa)
	ENSSSAP00000046253	CDC45 cell division cycle 45 homolog (S. cerevisiae). (421 aa)
	cdc45	CDC45-related protein. (569 aa)
	ENSSSAP00000043443	annotation not available (148 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
	LOC106608315	Zygotic DNA replication licensing factor mcm3-like. (385 aa)
	wrn	Werner syndrome ATP-dependent helicase isoform X2. (1467 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (886 aa)
	LOC106569286	DNA helicase; Belongs to the MCM family. (826 aa)
	mc6zb	DNA helicase; Belongs to the MCM family. (838 aa)
	ENSSSAP00000028441	annotation not available (109 aa)
	recql4	ATP-dependent DNA helicase Q4. (1404 aa)
	ENSSSAP00000019926	annotation not available (202 aa)
	LOC106607055	DNA replication licensing factor mcm5-like; Belongs to the MCM family. (525 aa)
	mcm7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
	ENSSSAP00000010800	annotation not available (742 aa)
	LOC106606972	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (443 aa)
	LOC106607888	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	ENSSSAP00000005368	annotation not available (283 aa)
	ENSSSAP00000002832	annotation not available (282 aa)
	LOC106601412	ATP-dependent DNA helicase Q5-like. (798 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSSAP00000002832	ENSSSAP00000019926	ENSSSAP00000002832	ENSSSAP00000019926	annotation not available	annotation not available	0.827
ENSSSAP00000002832	ENSSSAP00000046253	ENSSSAP00000002832	ENSSSAP00000046253	annotation not available	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.545
ENSSSAP00000002832	LOC106569128	ENSSSAP00000002832	ENSSSAP00000121093	annotation not available	DNA helicase; Belongs to the MCM family.	0.423
ENSSSAP00000002832	LOC106607888	ENSSSAP00000002832	ENSSSAP00000005863	annotation not available	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.803
ENSSSAP00000002832	LOC106612933	ENSSSAP00000002832	ENSSSAP00000062367	annotation not available	Replication protein A 70 kDa DNA-binding subunit-like.	0.827
ENSSSAP00000002832	cdc45	ENSSSAP00000002832	ENSSSAP00000045772	annotation not available	CDC45-related protein.	0.545
ENSSSAP00000002832	mcm4	ENSSSAP00000002832	ENSSSAP00000090708	annotation not available	DNA helicase; Belongs to the MCM family.	0.423
ENSSSAP00000002832	mcm7	ENSSSAP00000002832	ENSSSAP00000011011	annotation not available	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.403
ENSSSAP00000002832	rad51	ENSSSAP00000002832	ENSSSAP00000042073	annotation not available	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.803
ENSSSAP00000002832	recql4	ENSSSAP00000002832	ENSSSAP00000026501	annotation not available	ATP-dependent DNA helicase Q4.	0.431
ENSSSAP00000002832	rfa1	ENSSSAP00000002832	ENSSSAP00000050494	annotation not available	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.827
ENSSSAP00000002832	wrn	ENSSSAP00000002832	ENSSSAP00000037318	annotation not available	Werner syndrome ATP-dependent helicase isoform X2.	0.675
ENSSSAP00000005368	ENSSSAP00000019926	ENSSSAP00000005368	ENSSSAP00000019926	annotation not available	annotation not available	0.827
ENSSSAP00000005368	ENSSSAP00000046253	ENSSSAP00000005368	ENSSSAP00000046253	annotation not available	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.545
ENSSSAP00000005368	LOC106569128	ENSSSAP00000005368	ENSSSAP00000121093	annotation not available	DNA helicase; Belongs to the MCM family.	0.423
ENSSSAP00000005368	LOC106607888	ENSSSAP00000005368	ENSSSAP00000005863	annotation not available	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.803
ENSSSAP00000005368	LOC106612933	ENSSSAP00000005368	ENSSSAP00000062367	annotation not available	Replication protein A 70 kDa DNA-binding subunit-like.	0.827
ENSSSAP00000005368	cdc45	ENSSSAP00000005368	ENSSSAP00000045772	annotation not available	CDC45-related protein.	0.545
ENSSSAP00000005368	mcm4	ENSSSAP00000005368	ENSSSAP00000090708	annotation not available	DNA helicase; Belongs to the MCM family.	0.423
ENSSSAP00000005368	mcm7	ENSSSAP00000005368	ENSSSAP00000011011	annotation not available	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.403