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| | inip | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). (109 aa) |
| | LOC106596397 | Amyloid beta A4 precursor protein-binding family A member 1-like. (923 aa) |
| | brca2 | Breast cancer type 2 susceptibility protein isoform X5. (2826 aa) |
| | ENSSSAP00000049806 | annotation not available (1015 aa) |
| | ENSSSAP00000050168 | annotation not available (1176 aa) |
| | ercc6 | DNA excision repair protein ERCC-6. (1488 aa) |
| | ENSSSAP00000115468 | X-ray repair complementing defective repair in Chinese hamster cells 6. (364 aa) |
| | cop1 | E3 ubiquitin-protein ligase RFWD2 isoform X1. (732 aa) |
| | LOC106561972 | Apoptosis regulator BAX-like. (204 aa) |
| | LOC106574237 | Integrin beta; Belongs to the integrin beta chain family. (795 aa) |
| | LOC106593039 | BRCA1-associated ATM activator 1-like. (233 aa) |
| | LOC106613337 | Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa) |
| | LOC106583347 | SOSS complex subunit B1-like. (193 aa) |
| | LOC106587134 | Apoptosis regulator BAX-like. (204 aa) |
| | LOC106585648 | Serine/threonine-protein kinase Chk2-like isoform X2. (546 aa) |
| | LOC106581684 | SOSS complex subunit B2-like. (217 aa) |
| | LOC106577528 | Menin-like. (621 aa) |
| | ENSSSAP00000117653 | annotation not available (1164 aa) |
| | ENSSSAP00000117674 | annotation not available (417 aa) |
| | fancd2 | Fanconi anemia group D2 protein. (1490 aa) |
| | LOC106599971 | Serine/threonine-protein kinase STK11-like; Belongs to the protein kinase superfamily. (433 aa) |
| | LOC106567215 | DNA (Cytosine-5)-methyltransferase 3A-like isoform X3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1531 aa) |
| | LOC106578283 | DCN1-like protein. (338 aa) |
| | xrcc4 | DNA repair protein XRCC4 isoform X2. (336 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa) |
| | ENSSSAP00000059858 | annotation not available (300 aa) |
| | LOC106607346 | UNC93-like protein MFSD11. (448 aa) |
| | ENSSSAP00000060415 | annotation not available (971 aa) |
| | LOC106568011 | BRCA1-A complex subunit RAP80-like isoform X1. (1164 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | ENSSSAP00000064605 | annotation not available (137 aa) |
| | ENSSSAP00000065200 | annotation not available (1319 aa) |
| | LOC106582297 | BRCA1-associated RING domain protein 1-like isoform X1. (847 aa) |
| | ENSSSAP00000066696 | annotation not available (247 aa) |
| | ENSSSAP00000066770 | annotation not available (468 aa) |
| | ENSSSAP00000067658 | annotation not available (174 aa) |
| | ENSSSAP00000067693 | annotation not available (154 aa) |
| | ENSSSAP00000068563 | annotation not available (782 aa) |
| | STK11 | Serine/threonine-protein kinase STK11-like. (330 aa) |
| | ENSSSAP00000073229 | annotation not available (145 aa) |
| | LOC106607328 | Apoptosis regulator BAX-like. (194 aa) |
| | ENSSSAP00000073552 | annotation not available (175 aa) |
| | LOC106580118 | Serine/threonine-protein kinase Chk2-like isoform X1. (508 aa) |
| | ENSSSAP00000074156 | annotation not available (911 aa) |
| | atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2476 aa) |
| | LOC106613226 | Secreted frizzled-related protein 2-like. (317 aa) |
| | mfs11 | UNC93-like protein MFSD11. (453 aa) |
| | ENSSSAP00000003228 | annotation not available (187 aa) |
| | ku70 | ATP-dependent DNA helicase 2 subunit 1 isoform X1. (619 aa) |
| | ENSSSAP00000004860 | annotation not available (380 aa) |
| | LOC106604510 | NAD-dependent protein deacetylase sirtuin-1-like isoform X2. (713 aa) |
| | LOC100136559 | Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa) |
| | LOC106610674 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (828 aa) |
| | LOC106609895 | Transmembrane protein 109-like. (220 aa) |
| | LOC106607888 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | face1 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (513 aa) |
| | LOC106569504 | Mitogen-activated protein kinase kinase kinase MLT. (483 aa) |
| | LOC106602749 | Secreted frizzled-related protein 2-like. (293 aa) |
| | smpd1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (612 aa) |
| | ENSSSAP00000015576 | Abraxas 1, BRCA1 A complex subunit. (377 aa) |
| | ENSSSAP00000016990 | annotation not available (257 aa) |
| | LOC106576420 | Uncharacterized protein LOC106576420. (316 aa) |
| | LOC106610025 | Secreted frizzled-related protein 2-like. (293 aa) |
| | LOC106570353 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (627 aa) |
| | LOC106562352 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (866 aa) |
| | LOC106563167 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa) |
| | babam2 | BRCA1-A complex subunit BRE. (454 aa) |
| | ENSSSAP00000019688 | annotation not available (790 aa) |
| | cl032 | C12orf32 homolog. (316 aa) |
| | ticrr | Treslin isoform X2. (1909 aa) |
| | ENSSSAP00000020795 | annotation not available (1267 aa) |
| | DNSL3-2 | Deoxyribonuclease-1-like protein. (238 aa) |
| | ENSSSAP00000022346 | annotation not available (1267 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double- [...] (260 aa) |
| | LOC106603421 | BRCA1-A complex subunit RAP80-like. (1105 aa) |
| | LOC106575791 | SOSS complex subunit B2-like. (203 aa) |
| | ENSSSAP00000025150 | annotation not available (92 aa) |
| | LOC106601126 | Apoptosis regulator BAX-like. (225 aa) |
| | LOC106593795 | BRCA1-associated ATM activator 1-like. (89 aa) |
| | lig4 | DNA ligase. (927 aa) |
| | ENSSSAP00000030324 | annotation not available (845 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (538 aa) |
| | ENSSSAP00000074925 | annotation not available (436 aa) |
| | ENSSSAP00000030774 | annotation not available (144 aa) |
| | ENSSSAP00000031057 | annotation not available (257 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1. (373 aa) |
| | LOC106601112 | UNC93-like protein MFSD11. (464 aa) |
| | sirt1 | NAD-dependent protein deacetylase sirtuin-1. (783 aa) |
| | LOC106600668 | Uncharacterized protein LOC106600668. (847 aa) |
| | ENSSSAP00000034587 | annotation not available (78 aa) |
| | STK11-2 | Serine/threonine-protein kinase STK11-like isoform X1; Belongs to the protein kinase superfamily. (427 aa) |
| | FBX4 | F-box only protein 4. (408 aa) |
| | LOC106590185 | DNA topoisomerase 2-binding protein 1-A-like. (1534 aa) |
| | LOC106598796 | Deoxyribonuclease; Belongs to the DNase I family. (278 aa) |
| | wrn | Werner syndrome ATP-dependent helicase isoform X2. (1467 aa) |
| | DNSL3 | Deoxyribonuclease; Belongs to the DNase I family. (352 aa) |
| | LOC106608272 | DNA helicase INO80-like isoform X2. (1279 aa) |
| | ptprc | Receptor-type tyrosine-protein phosphatase C isoform X1. (1412 aa) |
| | ENSSSAP00000079966 | annotation not available (1325 aa) |
| | ENSSSAP00000080183 | annotation not available (109 aa) |
| | LOC106583694 | Deoxyribonuclease; Belongs to the DNase I family. (303 aa) |
| | LOC106584172 | Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (157 aa) |
| | ENSSSAP00000088143 | annotation not available (1274 aa) |
| | LOC106584307 | Protein ECT2-like isoform X1. (1012 aa) |
| | spidr | DNA repair-scaffolding protein. (990 aa) |
| | LOC106589035 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (667 aa) |
| | ect2 | Protein ECT2 isoform X1. (1084 aa) |
| | LOC106569880 | Integrator complex subunit 3-like isoform X2. (1031 aa) |
| | LOC106581757 | Mitogen-activated protein kinase kinase kinase MLT-like isoform X1. (855 aa) |
| | LOC106581758 | Cell division cycle-associated protein 7-like isoform X2. (399 aa) |
| | LOC100380865 | Lysine--tRNA ligase. (644 aa) |
| | ercc8 | DNA excision repair protein ERCC-8 isoform X1. (400 aa) |
| | LOC106579247 | DCN1-like protein. (333 aa) |
| | ENSSSAP00000094070 | annotation not available (89 aa) |
| | LOC106580664 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (557 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (404 aa) |
| | LOC106568576 | SOSS complex subunit C-like. (80 aa) |
| | LOC106578660 | DNA topoisomerase 2-binding protein 1-A-like isoform X1. (1446 aa) |
| | LOC106585761 | DNA repair protein XRCC4-like isoform X1. (317 aa) |
| | LOC106572465 | DNA (Cytosine-5)-methyltransferase 3A-like isoform X2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1783 aa) |
| | cssa09h5orf45 | UPF0544 protein C5orf45 homolog isoform X1. (100 aa) |
| | XRCC2 | DNA repair protein XRCC2-like. (307 aa) |
| | LOC106566498 | ETS domain-containing protein Elk-1-like isoform X1. (544 aa) |
| | LOC106579593 | Apoptosis regulator Bcl-2-like. (228 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (928 aa) |
| | abcg5 | ATP-binding cassette sub-family G member 5. (698 aa) |
| | LOC106602586 | Transmembrane protein 109-like. (225 aa) |
| | ENSSSAP00000101354 | annotation not available (348 aa) |
| | ercc1 | DNA excision repair protein ERCC-1. (383 aa) |
| | ENSSSAP00000103411 | annotation not available (112 aa) |
| | ENSSSAP00000103639 | annotation not available (819 aa) |
| | LOC106587184 | Lysine--tRNA ligase. (603 aa) |
| | ENSSSAP00000105257 | Serine-protein kinase ATM-like. (111 aa) |
| | brca1 | Breast cancer type 1 susceptibility protein isoform X2. (1567 aa) |
| | ENSSSAP00000107681 | annotation not available (681 aa) |
| | LOC106599248 | Apoptosis regulator Bcl-2-like. (226 aa) |
| | LOC106603169 | Lys-63-specific deubiquitinase BRCC36-like isoform X1. (260 aa) |
| | LOC106563563 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | blm | Bloom syndrome protein isoform X1. (1471 aa) |
| | tank | LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator. (332 aa) |
| | rad9b | Cell cycle checkpoint control protein RAD9B. (301 aa) |
| | LOC106569189 | Apoptosis regulator Bcl-2-like isoform X2. (226 aa) |
| | LOC106586184 | TRAF family member-associated NF-kappa-B activator-like isoform X1. (361 aa) |
| | BCL2 | Apoptosis regulator Bcl-2-like. (230 aa) |
| | LOC106588323 | Integrator complex subunit 3 isoform X2. (1031 aa) |
| | LOC106569074 | E3 ubiquitin-protein ligase RFWD2-like isoform X3. (739 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | LOC106608591 | Menin-like isoform X1. (620 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3172 aa) |
| | LOC106575165 | Integrin beta; Belongs to the integrin beta chain family. (774 aa) |
| | NABP2 | SOSS complex subunit B1-B-like isoform X1. (199 aa) |
| | ENSSSAP00000046409 | DNA (cytosine-5)-methyltransferase 3A-like. (146 aa) |
| | LOC106562517 | Tumor suppressor p53-binding protein 1-like isoform X3. (1923 aa) |
