(140 nodes) T cell differentiation network (Salmo salar)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lef1	Lymphoid enhancer-binding factor 1 isoform X5. (408 aa)
	BATF	Basic leucine zipper transcriptional factor ATF-like. (138 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1. (587 aa)
	LOC106580090	Cytosolic carboxypeptidase 1-like isoform X4. (1211 aa)
	LOC106563704	LOW QUALITY PROTEIN: cytokine receptor common subunit gamma-like. (326 aa)
	THEMIS2	Protein THEMIS2 isoform X1. (567 aa)
	ENSSSAP00000052783	annotation not available (109 aa)
	ENSSSAP00000052966	annotation not available (175 aa)
	LOC106574888	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (625 aa)
	LOC106593089	Caspase recruitment domain-containing protein 11-like. (223 aa)
	LOC106570581	Interleukin-6 isoform A. (222 aa)
	il6ra	Interleukin-6 receptor subunit alpha isoform X1. (818 aa)
	LOC106613337	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	LOC106582662	Uncharacterized protein LOC106582662 isoform X2. (790 aa)
	LOC106563284	Tyrosine-protein kinase. (1099 aa)
	LOC106587145	Receptor-interacting serine/threonine-protein kinase 2-like. (528 aa)
	LOC106582378	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (601 aa)
	ripk4	Receptor-interacting serine/threonine-protein kinase 4 isoform X1; Belongs to the protein kinase superfamily. (490 aa)
	LOC106592197	Adapter protein CIKS-like isoform X1. (109 aa)
	LOC106581023	Forkhead box protein N1-like. (604 aa)
	PRR7	Proline-rich protein 7-like. (257 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC100136479	CD83 antigen isoform X2. (229 aa)
	LOC106568833	Frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
	irf1	Interferon regulatory factor. (334 aa)
	LOC106575960	G-protein coupled receptor 183-like isoform X2; Belongs to the G-protein coupled receptor 1 family. (320 aa)
	ENSSSAP00000066210	annotation not available (68 aa)
	LOC106581291	CD83 antigen-like. (217 aa)
	LOC106584369	Tyrosine-protein kinase. (633 aa)
	ENSSSAP00000067827	annotation not available (265 aa)
	SP3	Transcription factor Sp3-like isoform X1. (703 aa)
	ENSSSAP00000069053	annotation not available (624 aa)
	LOC106565454	Hamartin-like. (1271 aa)
	lepr	Leptin receptor isoform X1. (1146 aa)
	LOC106593572	Uncharacterized protein LOC106593572 isoform X1. (719 aa)
	STK11	Serine/threonine-protein kinase STK11-like. (330 aa)
	ENSSSAP00000073229	annotation not available (145 aa)
	LOC106607589	H2.0-like homeobox protein isoform X1. (370 aa)
	STK11-2	Serine/threonine-protein kinase STK11-like isoform X1; Belongs to the protein kinase superfamily. (427 aa)
	LOC106568720	Tyrosine-protein kinase. (1164 aa)
	LOC106567524	Lymphoid enhancer-binding factor 1-like isoform X1. (511 aa)
	LOC100136450	CD8 alpha precursor. (226 aa)
	LOC106584960	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (449 aa)
	LOC100380649	Hamartin isoform X3. (1273 aa)
	LOC106584839	Serum response factor-like isoform X1. (529 aa)
	LOC106592457	Serine/threonine-protein kinase 10-like isoform X1. (314 aa)
	LOC106594932	piggyBac transposable element-derived protein 4-like. (423 aa)
	nkx2-3	Homeobox protein Nkx-2.3. (340 aa)
	NKX2-3	NK2 homeobox 3. (398 aa)
	LOC106610386	Adapter protein CIKS-like isoform X1. (433 aa)
	LOC100136559	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC106599087	Roquin-1-like isoform X1. (1425 aa)
	LOC106604553	SAM and SH3 domain-containing protein 3-like. (399 aa)
	rag2	V(D)J recombination-activating protein 2. (533 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1078 aa)
	LOC106566176	Sperm-specific antigen 2 homolog. (911 aa)
	LOC106573411	Receptor-interacting serine/threonine-protein kinase 3-like; Belongs to the protein kinase superfamily. (365 aa)
	LOC106603814	Transcription factor 7-like 2 isoform X3. (472 aa)
	sash3	SAM and SH3 domain-containing protein 3. (400 aa)
	LOC106573951	Roquin-1-like isoform X1. (960 aa)
	nkx23	Homeobox protein Nkx-2.3. (368 aa)
	LOC106563758	Interleukin-7 receptor subunit alpha-like isoform X2. (421 aa)
	LOC106586045	G-protein coupled receptor 183-like. (389 aa)
	GPR183	G-protein coupled receptor 183-like; Belongs to the G-protein coupled receptor 1 family. (407 aa)
	tsc1	Hamartin isoform X2. (1227 aa)
	LOC106593637	Caspase recruitment domain-containing protein 11-like isoform X1. (175 aa)
	LOC106612922	Forkhead box protein N1-like isoform X1. (592 aa)
	LOC106560352	Proteasome subunit beta type-11-like. (347 aa)
	LOC106599491	Frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	ptprc	Receptor-type tyrosine-protein phosphatase C isoform X1. (1412 aa)
	LOC106589292	Eomesodermin-like isoform X1. (624 aa)
	LOC106562048	Receptor-interacting serine/threonine-protein kinase 2-like isoform X2. (541 aa)
	irf1-2	Interferon regulatory factor. (332 aa)
	LOC106607737	Adapter protein CIKS-like. (105 aa)
	LOC106604286	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (351 aa)
	abl2	Tyrosine-protein kinase. (1226 aa)
	agtpbp1	Cytosolic carboxypeptidase 1 isoform X2. (1162 aa)
	LOC106605107	Protein THEMIS2-like isoform X1. (539 aa)
	pe2r4	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (472 aa)
	LOC106568165	Interleukin-7 receptor subunit alpha-like isoform X2. (422 aa)
	LOC106607240	Transmembrane protein 98-like isoform X1. (248 aa)
	LOC106568754	Receptor-interacting serine/threonine-protein kinase 2-like isoform X1. (598 aa)
	LOC106560959	Cytosolic carboxypeptidase 4-like. (1230 aa)
	LOC106607753	Protein THEMIS-like. (689 aa)
	SP3-2	Transcription factor Sp3-like isoform X1. (696 aa)
	ENSSSAP00000092301	annotation not available (107 aa)
	LOC106569025	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (492 aa)
	rabl3	Rab-like protein 3 isoform X1. (233 aa)
	LOC106564784	Serum response factor-like isoform X1. (528 aa)
	LOC106575369	Transcription factor Sp3-like isoform X1. (654 aa)
	ENSSSAP00000098812	annotation not available (100 aa)
	LOC106580566	Prostaglandin E2 receptor EP4 subtype-like isoform X1; Belongs to the G-protein coupled receptor 1 family. (430 aa)
	LOC106599187	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (491 aa)
	LOC106589761	Homeobox protein Nkx-2.5-like. (340 aa)
	SRF	Serum response factor-like isoform X1. (596 aa)
	syk	Tyrosine-protein kinase. (624 aa)
	cd3e	CD3epsilon isoform 1 precursor. (181 aa)
	LOC106580890	T-cell surface glycoprotein CD3 delta chain-like. (120 aa)
	LOC106563563	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	LOC106568685	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (472 aa)
	LOC106576882	Serum response factor-like isoform X4. (566 aa)
	ENSSSAP00000112497	Transcription factor Sp3-like. (442 aa)
	LOC106578536	Frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	LOC106561969	FAS-associated death domain protein-like. (195 aa)
	LOC106584319	Tyrosine-protein kinase. (1191 aa)
	ENSSSAP00000117674	annotation not available (417 aa)
	LOC100286690	Tyrosine-protein kinase. (1172 aa)
	lepr2	Leptin receptor-like isoform X1. (1147 aa)
	LOC106599971	Serine/threonine-protein kinase STK11-like; Belongs to the protein kinase superfamily. (433 aa)
	LOC100136515	CD3gammadelta-A precursor. (198 aa)
	tbx21	T-box transcription factor TBX21 isoform X1. (612 aa)
	LOC106603484	Proline-rich protein 7-like. (260 aa)
	LOC106613845	Tyrosine-protein kinase. (613 aa)
	LOC106568378	Roquin-2-like isoform X1. (1235 aa)
	ENSSSAP00000028991	annotation not available (186 aa)
	lig4	DNA ligase. (927 aa)
	hlx	H2.0-like homeobox protein isoform X1. (366 aa)
	ENSSSAP00000030774	annotation not available (144 aa)
	LOC106568923	Roquin-1-like isoform X2. (1085 aa)
	jak1	Tyrosine-protein kinase. (1162 aa)
	LOC106600795	Transmembrane protein 98-like isoform X1. (248 aa)
	LOC106606877	Uncharacterized protein LOC106606877. (517 aa)
	LOC106612126	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (389 aa)
	gpr18	N-arachidonyl glycine receptor isoform X1. (348 aa)
	ebi2	G-protein coupled receptor 183; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (B [...] (366 aa)
	LOC106581630	G-protein coupled receptor 183-like; Belongs to the G-protein coupled receptor 1 family. (343 aa)
	LOC106601582	Armadillo repeat-containing protein 5-like. (884 aa)
	LOC106587129	FAS-associated death domain protein-like. (221 aa)
	LOC106581183	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC106613585	Roquin-1-like isoform X1. (1057 aa)
	LOC106598436	Tyrosine-protein kinase. (1155 aa)
	LOC106588787	Interleukin-6-like. (311 aa)
	LOC106566947	Tyrosine-protein kinase. (1113 aa)
	ENSSSAP00000042731	annotation not available (168 aa)
	LOC106571033	Basic leucine zipper transcriptional factor ATF-like. (131 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2569 aa)
	LOC106571130	Zinc finger and BTB domain-containing protein 1-like. (697 aa)
	LOC106598039	Proteasome subunit beta type-11-like. (388 aa)
	LOC106586337	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	LOC106561687	Roquin-2-like isoform X1. (1099 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	LOC100136450	ENSSSAP00000051234	ENSSSAP00000077139	Basic leucine zipper transcriptional factor ATF-like.	CD8 alpha precursor.	0.503
ENSSSAP00000030774	LOC106593572	ENSSSAP00000030774	ENSSSAP00000072329	annotation not available	Uncharacterized protein LOC106593572 isoform X1.	0.867
ENSSSAP00000030774	mtor	ENSSSAP00000030774	ENSSSAP00000045512	annotation not available	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.867
ENSSSAP00000030774	rag1	ENSSSAP00000030774	ENSSSAP00000009112	annotation not available	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.428
ENSSSAP00000030774	rag2	ENSSSAP00000030774	ENSSSAP00000009083	annotation not available	V(D)J recombination-activating protein 2.	0.455
ENSSSAP00000042731	LOC100136515	ENSSSAP00000042731	ENSSSAP00000020511	annotation not available	CD3gammadelta-A precursor.	0.891
ENSSSAP00000042731	LOC106563704	ENSSSAP00000042731	ENSSSAP00000052495	annotation not available	LOW QUALITY PROTEIN: cytokine receptor common subunit gamma-like.	0.614
ENSSSAP00000042731	LOC106563758	ENSSSAP00000042731	ENSSSAP00000019177	annotation not available	Interleukin-7 receptor subunit alpha-like isoform X2.	0.593
ENSSSAP00000042731	LOC106568165	ENSSSAP00000042731	ENSSSAP00000089315	annotation not available	Interleukin-7 receptor subunit alpha-like isoform X2.	0.593
ENSSSAP00000042731	LOC106580890	ENSSSAP00000042731	ENSSSAP00000106861	annotation not available	T-cell surface glycoprotein CD3 delta chain-like.	0.891
ENSSSAP00000042731	LOC106584369	ENSSSAP00000042731	ENSSSAP00000066882	annotation not available	Tyrosine-protein kinase.	0.464
ENSSSAP00000042731	LOC106589292	ENSSSAP00000042731	ENSSSAP00000081049	annotation not available	Eomesodermin-like isoform X1.	0.540
ENSSSAP00000042731	LOC106594932	ENSSSAP00000042731	ENSSSAP00000000970	annotation not available	piggyBac transposable element-derived protein 4-like.	0.891
ENSSSAP00000042731	LOC106613845	ENSSSAP00000042731	ENSSSAP00000023443	annotation not available	Tyrosine-protein kinase.	0.464
ENSSSAP00000042731	cd3e	ENSSSAP00000042731	ENSSSAP00000106855	annotation not available	CD3epsilon isoform 1 precursor.	0.967
ENSSSAP00000042731	ptprc	ENSSSAP00000042731	ENSSSAP00000079402	annotation not available	Receptor-type tyrosine-protein phosphatase C isoform X1.	0.689
ENSSSAP00000042731	rag1	ENSSSAP00000042731	ENSSSAP00000009112	annotation not available	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.511
ENSSSAP00000042731	rag2	ENSSSAP00000042731	ENSSSAP00000009083	annotation not available	V(D)J recombination-activating protein 2.	0.511
ENSSSAP00000042731	syk	ENSSSAP00000042731	ENSSSAP00000106369	annotation not available	Tyrosine-protein kinase.	0.464
ENSSSAP00000042731	tbx21	ENSSSAP00000042731	ENSSSAP00000022763	annotation not available	T-box transcription factor TBX21 isoform X1.	0.540