(130 nodes) Regulation of cellular pH network (Salmo salar)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSSAP00000121021	RAB7a, member RAS oncogene family. (308 aa)
	ENSSSAP00000109642	Solute carrier family 9 (sodium/hydrogen exchanger), member 6/7. (705 aa)
	LOC106574399	Anion exchange protein. (1120 aa)
	LOC106581805	Anion exchange protein. (1129 aa)
	LOC106588481	Palmitoyl-protein thioesterase 1-like. (324 aa)
	LOC106569189	Apoptosis regulator Bcl-2-like isoform X2. (226 aa)
	LOC106604771	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (824 aa)
	LOC106586186	Anion exchange protein. (1197 aa)
	BCL2	Apoptosis regulator Bcl-2-like. (230 aa)
	LOC106561977	Carbonic anhydrase 7-like isoform X1; Belongs to the alpha-carbonic anhydrase family. (283 aa)
	RAB7A	Ras-related protein Rab-7a-like. (217 aa)
	LOC106585121	Anion exchange protein. (1090 aa)
	LOC106580514	Anion exchange protein. (1156 aa)
	LOC100196679	ATP synthase subunit beta, mitochondrial. (517 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (273 aa)
	LOC106600548	V-type proton ATPase subunit S1-like isoform X1. (348 aa)
	LOC106601556	Granulins-like isoform X1. (899 aa)
	cln3	Battenin. (440 aa)
	LOC106601647	Band 3 anion exchange protein-like. (401 aa)
	LOC100136392	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (502 aa)
	LOC106569503	Anion exchange protein. (1106 aa)
	LOC100380859	Anion exchange protein. (919 aa)
	LOC106609897	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
	LOC106560271	GDT1 family protein. (447 aa)
	LOC106601026	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (843 aa)
	LOC106603325	Uncharacterized protein CXorf21 homolog. (268 aa)
	LOC106575664	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (869 aa)
	LOC106581993	Uncharacterized protein CXorf21 homolog. (415 aa)
	lrrk2	Leucine-rich repeat serine/threonine-protein kinase 2 isoform X2. (2564 aa)
	LOC106579607	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
	renr	Renin receptor precursor. (362 aa)
	ENSSSAP00000018285	annotation not available (809 aa)
	LOC106568053	Uncharacterized protein CXorf21 homolog isoform X1. (281 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (843 aa)
	LOC106564794	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (849 aa)
	LOC106592393	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (882 aa)
	LOC106570377	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (764 aa)
	slc9a8	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (664 aa)
	ENSSSAP00000025196	annotation not available (271 aa)
	ENSSSAP00000025682	annotation not available (58 aa)
	LOC106582135	Ras-related protein Rab-20-like. (258 aa)
	ENSSSAP00000026513	annotation not available (101 aa)
	LOC106562986	Anion exchange protein. (1042 aa)
	ENSSSAP00000027429	annotation not available (52 aa)
	ENSSSAP00000028449	Ubiquitin-protein ligase E3A-like. (578 aa)
	LOC106585562	Sodium bicarbonate cotransporter 3-like isoform X1. (1398 aa)
	LOC106586823	Anion exchange protein. (1251 aa)
	ENSSSAP00000030646	annotation not available (198 aa)
	ENSSSAP00000031313	annotation not available (81 aa)
	ENSSSAP00000031539	annotation not available (244 aa)
	LOC106585562-2	Sodium bicarbonate cotransporter 3-like isoform X3. (395 aa)
	LOC106588021	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (435 aa)
	LOC106588022	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (873 aa)
	LOC106566310	V-type proton ATPase subunit S1-like. (490 aa)
	LOC106574550	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
	LOC106567107	V-type proton ATPase subunit S1-like. (463 aa)
	LOC106584979	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (851 aa)
	LOC106565552	Ras-related protein Rab-7a. (246 aa)
	ENSSSAP00000038486	annotation not available (161 aa)
	LOC106612880	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (346 aa)
	LOC106605147	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (821 aa)
	LOC106586714	Uncharacterized protein LOC106586714. (519 aa)
	LOC106597086	Anion exchange protein. (1251 aa)
	LOC106574119	Ubiquitin-protein ligase E3A-like isoform X2. (908 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (884 aa)
	LOC106579849	Ras-related protein Rab-7a-like. (211 aa)
	LOC106563705	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (760 aa)
	ENSSSAP00000050583	annotation not available (395 aa)
	ENSSSAP00000051821	annotation not available (72 aa)
	LOC106566422	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (647 aa)
	lacc1	Laccase domain-containing protein 1. (483 aa)
	LOC106580324	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (851 aa)
	LOC106563067	Ras-related protein Rab-7a-like. (205 aa)
	LOC106612664	Transmembrane protein 199-like. (199 aa)
	LOC100286620	dmX-like protein 2. (2852 aa)
	LOC106575295	Anion exchange protein. (1131 aa)
	snapin	SNARE-associated protein Snapin. (129 aa)
	LOC106581928	Anion exchange protein. (1286 aa)
	LOC106563184	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (849 aa)
	LOC106569766	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (849 aa)
	SLC9A3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (801 aa)
	ENSSSAP00000067932	annotation not available (52 aa)
	LOC106595437	V-type proton ATPase subunit d 1-like. (329 aa)
	LOC106590174	Anion exchange protein. (1222 aa)
	atp6v0a1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (870 aa)
	LOC106570032	Palmitoyl-protein thioesterase 1-like. (328 aa)
	ENSSSAP00000070426	annotation not available (219 aa)
	ca7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (263 aa)
	LOC106560965	Sodium/hydrogen exchanger 10-like. (1177 aa)
	LOC106611718	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (708 aa)
	ENSSSAP00000073421	annotation not available (283 aa)
	tm9sf4	Transmembrane 9 superfamily member 2/4. (655 aa)
	ENSSSAP00000074784	annotation not available (726 aa)
	LOC106586672	Ras-related protein Rab-20-like. (286 aa)
	ENSSSAP00000077255	Dmx-like 2. (1997 aa)
	LOC106584122	GDT1 family protein. (325 aa)
	cln6	Ceroid-lipofuscinosis neuronal protein 6. (307 aa)
	LOC106586777	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1083 aa)
	LOC106562935	Anion exchange protein. (1106 aa)
	LOC106562769	Ceroid-lipofuscinosis neuronal protein 6 homolog. (275 aa)
	LOC106586616	Ceroid-lipofuscinosis neuronal protein 6 homolog. (167 aa)
	LOC106583206	Ras-related protein Rab-7a-like isoform X1. (223 aa)
	LOC106568665	Anion exchange protein. (1274 aa)
	vpp3	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
	LOC106578671	Anion exchange protein. (1225 aa)
	dmxl1	dmX-like protein 1 isoform X1. (3057 aa)
	LOC106588950	Granulins-like isoform X2. (58 aa)
	LOC106568806	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (355 aa)
	LOC106570077	Anion exchange protein. (1264 aa)
	tm199	Transmembrane protein 199. (199 aa)
	LOC106569889	SNARE-associated protein Snapin-like isoform X1. (164 aa)
	LOC106579032	Granulins-like isoform X1. (838 aa)
	LOC106579091	Anion exchange protein. (930 aa)
	LOC106586710	Renin receptor-like. (372 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (824 aa)
	LOC106588241	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (857 aa)
	LOC106579593	Apoptosis regulator Bcl-2-like. (228 aa)
	LOC106582699	V-type proton ATPase subunit S1-like protein. (343 aa)
	tmem175	Transmembrane protein 175. (436 aa)
	LOC106567937	Ras-related protein Rab-7a-like. (242 aa)
	vps33a	Vacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (608 aa)
	LOC106563054	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (599 aa)
	LOC106585293	Vacuolar protein sorting-associated protein 33A-like; Belongs to the STXBP/unc-18/SEC1 family. (621 aa)
	vatb2	Salmo salar Vacuolar ATP synthase subunit B, brain isoform (vatb2), mRNA. (506 aa)
	LOC106583168	Anion exchange protein. (1119 aa)
	grn	Granulins precursor. (825 aa)
	LOC106566511	V-type proton ATPase subunit S1-like protein. (348 aa)
	ENSSSAP00000108090	Si:ch211-48m9.1. (1024 aa)
	LOC106599248	Apoptosis regulator Bcl-2-like. (226 aa)
	LOC106588196	Anion exchange protein. (1248 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6V0A1	ENSSSAP00000027429	ENSSSAP00000020493	ENSSSAP00000027429	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	annotation not available	0.970
ATP6V0A1	ENSSSAP00000050583	ENSSSAP00000020493	ENSSSAP00000050583	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	annotation not available	0.923
ATP6V0A1	ENSSSAP00000051821	ENSSSAP00000020493	ENSSSAP00000051821	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	annotation not available	0.914
ATP6V0A1	ENSSSAP00000077255	ENSSSAP00000020493	ENSSSAP00000077255	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Dmx-like 2.	0.402
ATP6V0A1	LOC100136392	ENSSSAP00000020493	ENSSSAP00000004057	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.980
ATP6V0A1	LOC100286620	ENSSSAP00000020493	ENSSSAP00000061154	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	dmX-like protein 2.	0.402
ATP6V0A1	LOC106563054	ENSSSAP00000020493	ENSSSAP00000102981	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.980
ATP6V0A1	LOC106563184	ENSSSAP00000020493	ENSSSAP00000063036	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.735
ATP6V0A1	LOC106564794	ENSSSAP00000020493	ENSSSAP00000022329	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.735
ATP6V0A1	LOC106566310	ENSSSAP00000020493	ENSSSAP00000033732	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit S1-like.	0.923
ATP6V0A1	LOC106566511	ENSSSAP00000020493	ENSSSAP00000106816	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit S1-like protein.	0.757
ATP6V0A1	LOC106567107	ENSSSAP00000020493	ENSSSAP00000034986	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit S1-like.	0.923
ATP6V0A1	LOC106568806	ENSSSAP00000020493	ENSSSAP00000090189	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.942
ATP6V0A1	LOC106579607	ENSSSAP00000020493	ENSSSAP00000015711	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.679
ATP6V0A1	LOC106580324	ENSSSAP00000020493	ENSSSAP00000058085	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.735
ATP6V0A1	LOC106582699	ENSSSAP00000020493	ENSSSAP00000099309	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit S1-like protein.	0.757
ATP6V0A1	LOC106584979	ENSSSAP00000020493	ENSSSAP00000035021	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.735
ATP6V0A1	LOC106586710	ENSSSAP00000020493	ENSSSAP00000097461	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Renin receptor-like.	0.926
ATP6V0A1	LOC106588021	ENSSSAP00000020493	ENSSSAP00000033222	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.980
ATP6V0A1	LOC106595437	ENSSSAP00000020493	ENSSSAP00000068652	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit d 1-like.	0.980