STRINGSTRING
LOC106601412 LOC106601412 ENSSSAP00000002832 ENSSSAP00000002832 ENSSSAP00000005368 ENSSSAP00000005368 LOC106606972 LOC106606972 nelfa nelfa rnf8 rnf8 LOC100380775 LOC100380775 ENSSSAP00000057692 ENSSSAP00000057692 eapp eapp LOC106580766 LOC106580766 LOC106580664 LOC106580664 LOC106585434 LOC106585434 nelfe nelfe LOC106580000 LOC106580000 LOC106588516 LOC106588516 ENSSSAP00000107400 ENSSSAP00000107400 ENSSSAP00000114968 ENSSSAP00000114968 sirt6 sirt6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106601412ATP-dependent DNA helicase Q5-like. (798 aa)
ENSSSAP00000002832annotation not available (282 aa)
ENSSSAP00000005368annotation not available (283 aa)
LOC106606972ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (443 aa)
nelfaNegative elongation factor A. (541 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (538 aa)
LOC100380775Negative elongation factor A. (551 aa)
ENSSSAP00000057692SPT5 homolog, DSIF elongation factor subunit. (1069 aa)
eappE2F-associated phosphoprotein. (300 aa)
LOC106580766Transcription elongation factor SPT5. (1085 aa)
LOC106580664E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (557 aa)
LOC106585434Negative elongation factor B-like. (712 aa)
nelfeNegative elongation factor E. (356 aa)
LOC106580000Negative elongation factor B-like. (598 aa)
LOC106588516Negative elongation factor E-like. (418 aa)
ENSSSAP00000107400E2F-associated phosphoprotein-like. (238 aa)
ENSSSAP00000114968annotation not available (273 aa)
sirt6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (383 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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