19 items (Salmo salar) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106576980	Single-stranded DNA cytosine deaminase-like. (213 aa)
	lig4	DNA ligase. (927 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (538 aa)
	ENSSSAP00000030774	annotation not available (144 aa)
	LOC106606528	ATPase family AAA domain-containing protein 5-like isoform X1. (1873 aa)
	exosc3	Exosome complex component RRP40. (244 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1386 aa)
	ENSSSAP00000044108	annotation not available (850 aa)
	LOC106571033	Basic leucine zipper transcriptional factor ATF-like. (131 aa)
	BATF	Basic leucine zipper transcriptional factor ATF-like. (138 aa)
	LOC106575151	Single-stranded DNA cytosine deaminase-like. (213 aa)
	LOC106593985	Uncharacterized protein KIAA1841-like. (407 aa)
	cd40l	CD40 ligand; Belongs to the tumor necrosis factor family. (264 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (64 aa)
	LOC106580664	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (557 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (928 aa)
	ercc1	DNA excision repair protein ERCC-1. (383 aa)
	LOC106564654	ATPase family AAA domain-containing protein 5-like isoform X2. (547 aa)
	mlh1	DNA mismatch repair protein Mlh1. (729 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	msh2	ENSSSAP00000051234	ENSSSAP00000099762	Basic leucine zipper transcriptional factor ATF-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.526
ENSSSAP00000030774	ENSSSAP00000044108	ENSSSAP00000030774	ENSSSAP00000044108	annotation not available	annotation not available	0.765
ENSSSAP00000030774	LOC106564654	ENSSSAP00000030774	ENSSSAP00000106444	annotation not available	ATPase family AAA domain-containing protein 5-like isoform X2.	0.765
ENSSSAP00000030774	LOC106606528	ENSSSAP00000030774	ENSSSAP00000035854	annotation not available	ATPase family AAA domain-containing protein 5-like isoform X1.	0.765
ENSSSAP00000030774	ercc1	ENSSSAP00000030774	ENSSSAP00000102627	annotation not available	DNA excision repair protein ERCC-1.	0.581
ENSSSAP00000030774	mlh1	ENSSSAP00000030774	ENSSSAP00000119639	annotation not available	DNA mismatch repair protein Mlh1.	0.613
ENSSSAP00000030774	msh2	ENSSSAP00000030774	ENSSSAP00000099762	annotation not available	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.622
ENSSSAP00000030774	msh6	ENSSSAP00000030774	ENSSSAP00000040921	annotation not available	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.625
ENSSSAP00000030774	ung	ENSSSAP00000030774	ENSSSAP00000074402	annotation not available	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.600
ENSSSAP00000044108	ENSSSAP00000030774	ENSSSAP00000044108	ENSSSAP00000030774	annotation not available	annotation not available	0.765
ENSSSAP00000044108	lig4	ENSSSAP00000044108	ENSSSAP00000029249	annotation not available	DNA ligase.	0.765
ENSSSAP00000044108	mlh1	ENSSSAP00000044108	ENSSSAP00000119639	annotation not available	DNA mismatch repair protein Mlh1.	0.492
ENSSSAP00000044108	msh2	ENSSSAP00000044108	ENSSSAP00000099762	annotation not available	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.605
ENSSSAP00000044108	msh6	ENSSSAP00000044108	ENSSSAP00000040921	annotation not available	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.656
LOC106564654	ENSSSAP00000030774	ENSSSAP00000106444	ENSSSAP00000030774	ATPase family AAA domain-containing protein 5-like isoform X2.	annotation not available	0.765
LOC106564654	lig4	ENSSSAP00000106444	ENSSSAP00000029249	ATPase family AAA domain-containing protein 5-like isoform X2.	DNA ligase.	0.765
LOC106564654	mlh1	ENSSSAP00000106444	ENSSSAP00000119639	ATPase family AAA domain-containing protein 5-like isoform X2.	DNA mismatch repair protein Mlh1.	0.492
LOC106564654	msh2	ENSSSAP00000106444	ENSSSAP00000099762	ATPase family AAA domain-containing protein 5-like isoform X2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.605
LOC106564654	msh6	ENSSSAP00000106444	ENSSSAP00000040921	ATPase family AAA domain-containing protein 5-like isoform X2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.656
LOC106571033	msh2	ENSSSAP00000044692	ENSSSAP00000099762	Basic leucine zipper transcriptional factor ATF-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.526