STRINGSTRING
rfc3 rfc3 pold4 pold4 pold3 pold3 meiob meiob parp2 parp2 rfc2 rfc2 LOC106576591 LOC106576591 LOC106576591-2 LOC106576591-2 RCBTB1 RCBTB1 LOC106613703 LOC106613703 ENSSSAP00000017829 ENSSSAP00000017829 PCNA PCNA ENSSSAP00000019392 ENSSSAP00000019392 ENSSSAP00000019926 ENSSSAP00000019926 ENSSSAP00000030199 ENSSSAP00000030199 LOC106601920 LOC106601920 LOC106606528 LOC106606528 ENSSSAP00000036217 ENSSSAP00000036217 Parp3 Parp3 LOC106580473 LOC106580473 polb polb ENSSSAP00000044108 ENSSSAP00000044108 LOC106592982 LOC106592982 ENSSSAP00000045345 ENSSSAP00000045345 DPOD1 DPOD1 ENSSSAP00000047854 ENSSSAP00000047854 rfa1 rfa1 apex1 apex1 rpa2 rpa2 parp1 parp1 LOC106588659 LOC106588659 LOC106574681 LOC106574681 LOC106612933 LOC106612933 ENSSSAP00000065248 ENSSSAP00000065248 LOC106580445 LOC106580445 adprhl2 adprhl2 rcbtb2 rcbtb2 apex2 apex2 LOC106600579 LOC106600579 ENSSSAP00000079200 ENSSSAP00000079200 pole3 pole3 rfc5 rfc5 pole pole ENSSSAP00000088520 ENSSSAP00000088520 LOC106605109 LOC106605109 rpa3 rpa3 rfc4 rfc4 ENSSSAP00000090923 ENSSSAP00000090923 dpoe4 dpoe4 LOC106567314 LOC106567314 LOC106570310 LOC106570310 pold2 pold2 ENSSSAP00000102908 ENSSSAP00000102908 LOC106564654 LOC106564654 LOC106575507 LOC106575507 LOC106589925 LOC106589925 pole2 pole2 FEN1 FEN1 ENSSSAP00000112721 ENSSSAP00000112721 LOC106565577 LOC106565577 lig1 lig1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc3Replication factor C subunit 3 isoform X1. (334 aa)
pold4DNA polymerase subunit delta-4. (125 aa)
pold3DNA polymerase delta subunit 3 isoform X1. (449 aa)
meiobMeiosis-specific with OB domain-containing protein isoform X1. (464 aa)
parp2Poly [ADP-ribose] polymerase. (658 aa)
rfc2Replication factor C subunit 2. (381 aa)
LOC106576591DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (342 aa)
LOC106576591-2DNA-(apurinic or apyrimidinic site) lyase-like. (342 aa)
RCBTB1RCC1 and BTB domain-containing protein 1-like isoform X1. (572 aa)
LOC106613703DNA polymerase epsilon subunit 4-like. (149 aa)
ENSSSAP00000017829annotation not available (191 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSSSAP00000019392Proliferating cell nuclear antigen. (218 aa)
ENSSSAP00000019926annotation not available (202 aa)
ENSSSAP00000030199annotation not available (162 aa)
LOC106601920DNA polymerase delta catalytic subunit-like. (681 aa)
LOC106606528ATPase family AAA domain-containing protein 5-like isoform X1. (1873 aa)
ENSSSAP00000036217annotation not available (352 aa)
Parp3Poly (ADP-ribose) polymerase family, member 3. (310 aa)
LOC106580473DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (312 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (344 aa)
ENSSSAP00000044108annotation not available (850 aa)
LOC106592982poly(ADP-ribose) glycohydrolase-like. (343 aa)
ENSSSAP00000045345annotation not available (48 aa)
DPOD1DNA polymerase. (899 aa)
ENSSSAP00000047854annotation not available (265 aa)
rfa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
apex1Salmo salar APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1), mRNA. (344 aa)
rpa2Replication protein A 32 kDa subunit. (278 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1030 aa)
LOC106588659Replication protein A 32 kDa subunit-A-like isoform X1. (266 aa)
LOC106574681RCC1 and BTB domain-containing protein 1-like isoform X3. (631 aa)
LOC106612933Replication protein A 70 kDa DNA-binding subunit-like. (632 aa)
ENSSSAP00000065248annotation not available (188 aa)
LOC106580445Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
adprhl2PolyADP-ribose glycohydrolase ARH3. (381 aa)
rcbtb2RCC1 and BTB domain-containing protein 2. (492 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (601 aa)
LOC106600579Von Willebrand factor A domain-containing protein 5B1-like. (1418 aa)
ENSSSAP00000079200Replication factor C (activator 1) 2. (372 aa)
pole3DNA-directed DNA polymerase epsilon 3. (151 aa)
rfc5Replication factor C subunit 5. (341 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
ENSSSAP00000088520Replication factor C (activator 1) 5. (305 aa)
LOC106605109Replication protein A 32 kDa subunit-like. (278 aa)
rpa3Replication protein A3. (159 aa)
rfc4Replication factor C subunit 4 isoform X1. (361 aa)
ENSSSAP00000090923annotation not available (91 aa)
dpoe4DNA-directed DNA polymerase epsilon 4. (130 aa)
LOC106567314DNA-(Apurinic or apyrimidinic site) lyase 2-like. (299 aa)
LOC106570310Replication protein A 14 kDa subunit-like. (147 aa)
pold2DNA polymerase subunit delta-2. (500 aa)
ENSSSAP00000102908annotation not available (83 aa)
LOC106564654ATPase family AAA domain-containing protein 5-like isoform X2. (547 aa)
LOC106575507RCC1 and BTB domain-containing protein 1-like isoform X4. (700 aa)
LOC106589925poly(ADP-ribose) glycohydrolase-like isoform X1. (995 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (567 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (402 aa)
ENSSSAP00000112721annotation not available (332 aa)
LOC106565577Poly [ADP-ribose] polymerase. (532 aa)
lig1DNA ligase. (1088 aa)
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.