(36 nodes) (2017) Estrogen exposure overrides the masculinizing effect of elevated temperature by a downregulation of the key genes implicated in sexual differentiation in a fish with mixed genetic and environmental sex determination. network (Salmo salar)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LOC106611270	Endoribonuclease Dicer-like; Belongs to the helicase family. Dicer subfamily. (2146 aa)
	RHO	Rhodopsin. (354 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (622 aa)
	LOC106583843	Histone deacetylase 11-like. (171 aa)
	LOC106590153	Transcription factor Sox-17-alpha-A-like. (390 aa)
	tesc	Calcineurin B homologous protein 3. (242 aa)
	LOC106587964	Heat shock factor-binding protein 1-like. (78 aa)
	LOC106596195	Heat shock 70 kDa protein; Belongs to the heat shock protein 70 family. (644 aa)
	LOC106578689	Transcription factor Sox-17-alpha-A-like. (393 aa)
	LOC106609475	Insulin-like growth factor I isoform X1. (211 aa)
	rig-I	Retinoic acid-inducible gene-I. (557 aa)
	rho	Rhodopsin. (343 aa)
	hspa8	Heat shock cognate 70 kDa protein; Belongs to the heat shock protein 70 family. (672 aa)
	LOC100136550	Insulin-like growth factor II. (214 aa)
	LOC106587170	Aromatase-like; Belongs to the cytochrome P450 family. (526 aa)
	LOC106566827	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	amh	Anti-mullerian hormone precursor. (600 aa)
	LOC106586001	Doublesex- and mab-3-related transcription factor 1-like. (188 aa)
	LOC106602420	Endoribonuclease Dicer-like isoform X1; Belongs to the helicase family. Dicer subfamily. (1995 aa)
	kmt2a	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4299 aa)
	LOC106567313	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (375 aa)
	LOC106572377	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (461 aa)
	hsp7c	Heat shock cognate 71 kDa protein isoform X1; Belongs to the heat shock protein 70 family. (716 aa)
	LOC106573700	Heat shock factor-binding protein 1-like. (78 aa)
	igf1r	Tyrosine-protein kinase receptor. (1425 aa)
	LOC106603659	Heat shock cognate 70 kDa protein; Belongs to the heat shock protein 70 family. (660 aa)
	hrsp12	Ribonuclease UK114. (373 aa)
	LOC106562534	Aromatase-like; Belongs to the cytochrome P450 family. (531 aa)
	egf	Pro-epidermal growth factor isoform X1. (1198 aa)
	LOC100380769	Histone-lysine N-methyltransferase EHMT2 isoform X2. (1265 aa)
	LOC106572223	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (443 aa)
	LOC106588513	Histone-lysine N-methyltransferase EHMT2-like isoform X1. (1186 aa)
	LOC100136370	Rhodopsin. (354 aa)
	gnrh	GnRH-associated peptide 3; Stimulates the secretion of gonadotropins. (82 aa)
	LOC100136430	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (604 aa)
	hsp10	Heat shock protein 10 isoform X1; Belongs to the GroES chaperonin family. (167 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100136370	RHO	ENSSSAP00000111426	ENSSSAP00000013279	Rhodopsin.	Rhodopsin.	0.916
LOC100136430	LOC106596195	ENSSSAP00000120238	ENSSSAP00000022644	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Heat shock 70 kDa protein; Belongs to the heat shock protein 70 family.	0.843
LOC100136430	LOC106602420	ENSSSAP00000120238	ENSSSAP00000075824	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Endoribonuclease Dicer-like isoform X1; Belongs to the helicase family. Dicer subfamily.	0.488
LOC100136430	LOC106603659	ENSSSAP00000120238	ENSSSAP00000088930	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Heat shock cognate 70 kDa protein; Belongs to the heat shock protein 70 family.	0.843
LOC100136430	LOC106611270	ENSSSAP00000120238	ENSSSAP00000005411	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Endoribonuclease Dicer-like; Belongs to the helicase family. Dicer subfamily.	0.488
LOC100136430	hsp10	ENSSSAP00000120238	ENSSSAP00000120250	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Heat shock protein 10 isoform X1; Belongs to the GroES chaperonin family.	0.996
LOC100136430	hsp7c	ENSSSAP00000120238	ENSSSAP00000084481	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Heat shock cognate 71 kDa protein isoform X1; Belongs to the heat shock protein 70 family.	0.843
LOC100136430	hspa8	ENSSSAP00000120238	ENSSSAP00000051241	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family.	Heat shock cognate 70 kDa protein; Belongs to the heat shock protein 70 family.	0.843
LOC100136550	LOC106609475	ENSSSAP00000051358	ENSSSAP00000040530	Insulin-like growth factor II.	Insulin-like growth factor I isoform X1.	0.777
LOC100136550	egf	ENSSSAP00000051358	ENSSSAP00000096201	Insulin-like growth factor II.	Pro-epidermal growth factor isoform X1.	0.584
LOC100136550	igf1r	ENSSSAP00000051358	ENSSSAP00000087788	Insulin-like growth factor II.	Tyrosine-protein kinase receptor.	0.983
LOC100380769	LOC106566827	ENSSSAP00000103249	ENSSSAP00000065808	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.465
LOC100380769	LOC106567313	ENSSSAP00000103249	ENSSSAP00000081555	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.485
LOC100380769	LOC106572223	ENSSSAP00000103249	ENSSSAP00000103771	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.471
LOC100380769	LOC106572377	ENSSSAP00000103249	ENSSSAP00000083192	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.477
LOC100380769	LOC106573700	ENSSSAP00000103249	ENSSSAP00000086679	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Heat shock factor-binding protein 1-like.	0.412
LOC100380769	LOC106583843	ENSSSAP00000103249	ENSSSAP00000018301	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Histone deacetylase 11-like.	0.734
LOC100380769	LOC106587964	ENSSSAP00000103249	ENSSSAP00000020942	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Heat shock factor-binding protein 1-like.	0.412
LOC100380769	LOC106602420	ENSSSAP00000103249	ENSSSAP00000075824	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Endoribonuclease Dicer-like isoform X1; Belongs to the helicase family. Dicer subfamily.	0.745
LOC100380769	LOC106611270	ENSSSAP00000103249	ENSSSAP00000005411	Histone-lysine N-methyltransferase EHMT2 isoform X2.	Endoribonuclease Dicer-like; Belongs to the helicase family. Dicer subfamily.	0.745