17 items (Salmo salar) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	il17d	interleukin-17D isoform X1. (206 aa)
	LOC100136352	Actin-1. (410 aa)
	LOC106564005	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	tlr3	Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (913 aa)
	TLR8	TLR8-like precursor; Belongs to the Toll-like receptor family. (1035 aa)
	TLR5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (658 aa)
	LOC106570581	Interleukin-6 isoform A. (222 aa)
	TLR-2	Toll-like receptor 13. (572 aa)
	IL-10	Interleukin-10-like. (123 aa)
	LOC106574396	Toll-like receptor 13. (931 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (269 aa)
	LOC100136512	Interleukin-10. (300 aa)
	LOC106581058	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	tlr9	Toll-like receptor 9 isoform X1; Belongs to the Toll-like receptor family. (1074 aa)
	tlr13	Toll-like receptor 22b; Belongs to the Toll-like receptor family. (962 aa)
	LOC106604777	Toll-like receptor 6. (837 aa)
	csf1	Macrophage colony-stimulating factor 1. (591 aa)

Your Current Organism:

Salmo salar

NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL-10	LOC100136352	ENSSSAP00000068333	ENSSSAP00000003534	Interleukin-10-like.	Actin-1.	0.565
IL-10	LOC100136512	ENSSSAP00000068333	ENSSSAP00000080196	Interleukin-10-like.	Interleukin-10.	0.900
IL-10	LOC106564005	ENSSSAP00000068333	ENSSSAP00000016461	Interleukin-10-like.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.565
IL-10	LOC106570581	ENSSSAP00000068333	ENSSSAP00000053478	Interleukin-10-like.	Interleukin-6 isoform A.	0.627
IL-10	LOC106574396	ENSSSAP00000068333	ENSSSAP00000079110	Interleukin-10-like.	Toll-like receptor 13.	0.464
IL-10	LOC106604777	ENSSSAP00000068333	ENSSSAP00000113763	Interleukin-10-like.	Toll-like receptor 6.	0.741
IL-10	TLR-2	ENSSSAP00000068333	ENSSSAP00000063294	Interleukin-10-like.	Toll-like receptor 13.	0.586
IL-10	TLR5	ENSSSAP00000068333	ENSSSAP00000041640	Interleukin-10-like.	Toll-like receptor 5; Belongs to the Toll-like receptor family.	0.762
IL-10	TLR8	ENSSSAP00000068333	ENSSSAP00000035750	Interleukin-10-like.	TLR8-like precursor; Belongs to the Toll-like receptor family.	0.531
IL-10	csf1	ENSSSAP00000068333	ENSSSAP00000119084	Interleukin-10-like.	Macrophage colony-stimulating factor 1.	0.470
IL-10	il17d	ENSSSAP00000068333	ENSSSAP00000069585	Interleukin-10-like.	interleukin-17D isoform X1.	0.555
IL-10	myd88	ENSSSAP00000068333	ENSSSAP00000080060	Interleukin-10-like.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.791
IL-10	tlr3	ENSSSAP00000068333	ENSSSAP00000032759	Interleukin-10-like.	Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family.	0.740
IL-10	tlr9	ENSSSAP00000068333	ENSSSAP00000106992	Interleukin-10-like.	Toll-like receptor 9 isoform X1; Belongs to the Toll-like receptor family.	0.641
LOC100136352	IL-10	ENSSSAP00000003534	ENSSSAP00000068333	Actin-1.	Interleukin-10-like.	0.565
LOC100136352	LOC100136512	ENSSSAP00000003534	ENSSSAP00000080196	Actin-1.	Interleukin-10.	0.565
LOC100136352	myd88	ENSSSAP00000003534	ENSSSAP00000080060	Actin-1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.457
LOC100136512	IL-10	ENSSSAP00000080196	ENSSSAP00000068333	Interleukin-10.	Interleukin-10-like.	0.900
LOC100136512	LOC100136352	ENSSSAP00000080196	ENSSSAP00000003534	Interleukin-10.	Actin-1.	0.565
LOC100136512	LOC106564005	ENSSSAP00000080196	ENSSSAP00000016461	Interleukin-10.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.565